Assembling the bacterial segrosome

Finbarr Hayes; Daniela Barillà

doi:10.1016/j.tibs.2006.03.002

Assembling the bacterial segrosome

Finbarr Hayes, Daniela Barillà

Research output: Contribution to journal › Article › peer-review

Abstract

Genome segregation in prokaryotes is a highly ordered process that integrates with DNA replication, cytokinesis and other fundamental facets of the bacterial cell cycle. The segrosome is the nucleoprotein complex that mediates DNA segregation in bacteria, its assembly and organization is best understood for plasmid partition. The recent elucidation of structures of the ParB plasmid segregation protein bound to centromeric DNA, and of the tertiary structures of other segregation proteins, are key milestones in the path to deciphering the molecular basis of bacterial DNA segregation. © 2006 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	247-250
Number of pages	3
Journal	Trends in Biochemical Sciences
Volume	31
Issue number	5
DOIs	https://doi.org/10.1016/j.tibs.2006.03.002
Publication status	Published - May 2006

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10.1016/j.tibs.2006.03.002

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title = "Assembling the bacterial segrosome",

abstract = "Genome segregation in prokaryotes is a highly ordered process that integrates with DNA replication, cytokinesis and other fundamental facets of the bacterial cell cycle. The segrosome is the nucleoprotein complex that mediates DNA segregation in bacteria, its assembly and organization is best understood for plasmid partition. The recent elucidation of structures of the ParB plasmid segregation protein bound to centromeric DNA, and of the tertiary structures of other segregation proteins, are key milestones in the path to deciphering the molecular basis of bacterial DNA segregation. {\textcopyright} 2006 Elsevier Ltd. All rights reserved.",

author = "Finbarr Hayes and Daniela Barill{\`a}",

year = "2006",

month = may,

doi = "10.1016/j.tibs.2006.03.002",

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volume = "31",

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journal = "Trends in Biochemical Sciences",

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AU - Barillà, Daniela

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N2 - Genome segregation in prokaryotes is a highly ordered process that integrates with DNA replication, cytokinesis and other fundamental facets of the bacterial cell cycle. The segrosome is the nucleoprotein complex that mediates DNA segregation in bacteria, its assembly and organization is best understood for plasmid partition. The recent elucidation of structures of the ParB plasmid segregation protein bound to centromeric DNA, and of the tertiary structures of other segregation proteins, are key milestones in the path to deciphering the molecular basis of bacterial DNA segregation. © 2006 Elsevier Ltd. All rights reserved.

AB - Genome segregation in prokaryotes is a highly ordered process that integrates with DNA replication, cytokinesis and other fundamental facets of the bacterial cell cycle. The segrosome is the nucleoprotein complex that mediates DNA segregation in bacteria, its assembly and organization is best understood for plasmid partition. The recent elucidation of structures of the ParB plasmid segregation protein bound to centromeric DNA, and of the tertiary structures of other segregation proteins, are key milestones in the path to deciphering the molecular basis of bacterial DNA segregation. © 2006 Elsevier Ltd. All rights reserved.

U2 - 10.1016/j.tibs.2006.03.002

DO - 10.1016/j.tibs.2006.03.002

M3 - Article

SN - 0968-0004

VL - 31

SP - 247

EP - 250

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

IS - 5

ER -

Assembling the bacterial segrosome

Abstract

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