Projects per year
Abstract
BACKGROUND AND PURPOSE
Studies in animal models suggest that inflammation is a major contributor to secondary injury after intracerebral hemorrhage (ICH). Direct, noninvasive monitoring of inflammation in the human brain after ICH will facilitate early-phase development of anti-inflammatory treatments. We sought to investigate the feasibility of multimodality brain imaging in subacute ICH.
METHODS
Acute ICH patients were recruited to undergo multiparametric MRI (including dynamic contrast-enhanced measurement of blood-brain barrier transfer constant (Ktrans) and PET with [11C]-(R)-PK11195). [11C]-(R)-PK11195 binds to the translocator protein 18 kDa (TSPO), which is rapidly upregulated in activated microglia. Circulating inflammatory markers were measured at the time of PET.
RESULTS
Five patients were recruited to this feasibility study with imaging between 5 and 16 days after onset. Etiologies included hypertension-related small vessel disease, cerebral amyloid angiopathy (CAA), cavernoma, and arteriovenous malformation (AVM). [11C]-(R)-PK11195 binding was low in all hematomas and 2 (patient 2 [probable CAA] and 4 [AVM]) cases showed widespread increase in binding in the perihematomal region versus contralateral. All had increased Ktrans in the perihematomal region (mean difference = 2.2 × 10−3 minute−1; SD = 1.6 × 10−3 minute−1) versus contralateral. Two cases (patients 1 [cavernoma] and 4 [AVM]) had delayed surgery (3 and 12 months post-onset, respectively) with biopsies showing intense microglial activation in perilesional tissue.
CONCLUSIONS
Our study demonstrates for the first time the feasibility of performing complex multimodality brain imaging for noninvasive monitoring of neuroinflammation for this severe stroke subtype.
Original language | English |
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Pages (from-to) | 158-161 |
Number of pages | 4 |
Journal | Journal of Neuroimaging |
Volume | 28 |
Issue number | 2 |
Early online date | 24 Oct 2017 |
DOIs | |
Publication status | Published - Mar 2018 |
Keywords
- intracerebral haemorrhage
- inflammation
- blood-brain barrier
- magnetic resonance imaging
- positron emission tomography
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Dive into the research topics of 'Assessing Inflammation in Acute Intracerebral Hemorrhage with PK11195 PET and Dynamic Contrast-Enhanced MRI'. Together they form a unique fingerprint.Projects
- 3 Finished
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Contribution of Neuro-inflammation to cerebral ischaemia
Brough, D. (PI), Allan, S. (CoI), Kostarelos, K. (CoI) & Rothwell, N. (CoI)
31/12/15 → 30/06/19
Project: Research
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Understanding the Therapeutic Potential of Interleukin-1 Inhibition in Intracerebral Haemorrhage.
Parry-Jones, A. (PI)
1/03/15 → 29/02/20
Project: Research
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Quantification of Vascular and Neuronal Pathology in Dementia Using PET and MRI.
Parker, G. (PI), Asselin, M.-C. (CoI), Boutin, H. (CoI), Burns, A. (CoI), Herholz, K. (CoI), Matthews, J. (CoI), Parkes, L. (CoI) & Williams, S. (CoI)
1/01/15 → 28/02/19
Project: Research