Assessing periarticular bone mineral density in patients with early psoriatic arthritis or rheumatoid arthritis

Beverley J. Harrison, C. E. Hutchinson, J. Adams, I. N. Bruce, A. L. Herrick

    Research output: Contribution to journalArticlepeer-review


    Background: Periarticular osteoporosis is an early finding in the hands of patients with rheumatoid arthritis (RA), due to release of bone resorbing cytokines from the inflamed synovium. There has been disagreement as to whether periarticular bone loss occurs in psoriatic arthritis (PsA). Bone mineral density (BMD) can now be measured accurately using dual energy x ray absorptiometry (DEXA). Recently, DEXA has been used to measure periarticular BMD at predefined regions of interest (ROIs) around the joints. Objectives: Firstly, to compare periarticular BMD around the finger joints of patients with early RA or PsA. Secondly, to determine whether periarticular bone loss is related to joint inflammation and radiological erosions in RA and PsA. Methods: Seventeen patients with RA and 15 with PsA were recruited, all with disease duration of less than five years. All finger joints were examined by one person for swelling, or tenderness, or both. Hand radiographs were scored for the presence of erosions. Periarticular BMD was measured at 10 predetermined ROIs using a Hologic QDA-4500A fan-beam densitometer. Results: Patients with PsA were less likely to be positive for rheumatoid factor (RF) (13% v 94%) and more likely to be men (60% v 23%) than patients with RA. There were no other clinical differences between patients with RA or PsA. Patients with RA had significantly lower BMD at each of the ROIs than those with PsA (p
    Original languageEnglish
    Pages (from-to)1007-1011
    Number of pages4
    JournalAnnals of the rheumatic diseases
    Issue number11
    Publication statusPublished - Nov 2002


    • Adult
    • Aged
    • Arthritis
    • Arthritis,Psoriatic
    • Arthritis,Rheumatoid
    • Bone Density
    • Comparative Study
    • complications
    • Densitometry,X-Ray
    • Disease
    • epidemiology
    • etiology
    • Female
    • Finger Joint
    • Hand
    • Human
    • Inflammation
    • Joints
    • Linear Models
    • Male
    • methods
    • Middle Age
    • Multicenter Studies
    • Osteoporosis
    • physiopathology
    • radiography
    • Reproducibility of Results
    • Rheumatoid Factor
    • Severity of Illness Index
    • Support,Non-U.S.Gov't


    Dive into the research topics of 'Assessing periarticular bone mineral density in patients with early psoriatic arthritis or rheumatoid arthritis'. Together they form a unique fingerprint.

    Cite this