Assessing the challenges of Fourier transform infrared spectroscopic analysis of blood serum

Caryn Hughes, Michael Brown, Graeme Clemens, Alex Henderson, Geraldine Monjardez, Noel W. Clarke, Peter Gardner

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    Abstract

    There are many approaches to measuring the infrared spectrum of a blood serum sample. Naturally, each approach will have both advantages and disadvantages. We report on the progress of the application of infrared spectroscopy in the field of blood serum analysis towards clinical application, with a focus on prostate cancer. In order to perform a high-powered study with clinical relevance, choosing the most suitable approach must undergo careful consideration. We review the possibilities of using different sample preparation methods and speculate upon the potential pitfalls of both transmission and attenuated total reflectance (ATR) techniques. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Original languageEnglish
    Pages (from-to)180-188
    Number of pages8
    JournalJournal of biophotonics
    Volume7
    Issue number3-4
    DOIs
    Publication statusPublished - 2014

    Keywords

    • ATR
    • Blood
    • FTIR
    • Prostate cancer
    • Serum
    • Transmission

    Research Beacons, Institutes and Platforms

    • Manchester Institute of Biotechnology

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