Assessment of PCL/carbon material scaffolds for bone regeneration

Weiguang Wang, Boyang Huang, Byun Jae Jong, Paulo Jorge Da Silva Bartolo

Research output: Contribution to journalArticlepeer-review

149 Downloads (Pure)


Biomanufacturing is a relatively new research domain focusing on the use of additive manufacturing technol- ogies, biomaterials, cells and biomolecular signals to produce tissue constructs for tissue engineering. For bone regeneration, researchers are focusing on the use of polymeric and polymer/ceramic scaffolds seeded with os- teoblasts or mesenchymal stem cells. However, the design of high-performance scaffolds in terms of mechanical, cell-stimulation and biological performance is still required. This is the first paper investigating the use of an extrusion additive manufacturing system to produce poly(ε-caprolactone) (PCL), PCL/graphene nanosheet (GNS) and PCL/carbon nanotube (CNT) scaffolds for bone applications. Scaffolds with regular and reproducible ar- chitecture were produced and evaluated from chemical, physical and biological points of view. Results suggest that the addition of both graphene and CNT allow the fabrication of scaffolds with improved properties. It also shows that scaffolds containing graphene present better mechanical properties and high cell-affinity improving cell attachment, proliferation and differentiation.
Original languageEnglish
Pages (from-to)52-60
Number of pages9
JournalJournal of the Mechanical Behavior of Materials
Early online date31 Jan 2019
Publication statusPublished - 1 May 2019


  • Biofabrication
  • Carbon nanotube
  • Graphene
  • Scaffold
  • Tissue engineering


Dive into the research topics of 'Assessment of PCL/carbon material scaffolds for bone regeneration'. Together they form a unique fingerprint.

Cite this