Assessment of Tumor Angiogenesis. Dynamic Contrast-enhanced MR Imaging and Beyond.

Research output: Contribution to journalReview articlepeer-review

Abstract

Dynamic contrast-enhanced (DCE) MR imaging is used increasingly often to evaluate tumor angiogenesis and the efficacy of antiangiogenic drugs. In clinical practice DCE-MR imaging applications are largely centered on lesion detection, characterization, and localization. In research, DCE-MR imaging helps inform decision making in early-phase clinical trials by showing efficacy and by selecting dose and schedule. However, the role of these techniques in patient selection is uncertain. Future research is required to optimize existing DCE-MR imaging methods and to fully validate these biomarkers for wider use in patient care and in drug development.

Original languageEnglish
Pages (from-to)45-56
Number of pages12
JournalMagnetic Resonance Imaging Clinics of North America
Volume24
Issue number1
DOIs
Publication statusPublished - 1 Feb 2016

Keywords

  • Angiogenesis
  • Biomarker
  • Clinical trials
  • DCE-MR imaging
  • Diagnosis
  • Quantitative imaging

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