Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NFκB signalling pathways

Catherine Potter; Heather J. Cordell; Anne Barton; Ann K. Daly; Kimme L. Hyrich; Derek A. Mann; Ann W. Morgan; Anthony G. Wilson; John D. Isaacs

doi:10.1136/ard.2009.117309

Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NFκB signalling pathways

Catherine Potter, Heather J. Cordell, Anne Barton, Ann K. Daly, Kimme L. Hyrich, Derek A. Mann, Ann W. Morgan, Anthony G. Wilson, John D. Isaacs

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: To determine whether genetic variation within genes integral to the Toll-like receptor (TLR) and NFκB signalling systems, two cardinal regulators of inflammatory and immune responses, contributes towards the observed variation in response to tumour necrosis factor (TNF) blocking agents in patients with rheumatoid arthritis (RA). Methods: Pairwise-tagging single nucleotide polymorphisms (SNPs) spanning 24 candidate genes were selected and genotyped in a large UK cohort of patients receiving anti-TNF therapy for RA. Multivariate regression analyses were performed to test association between individual genotypes, under an additive model, and treatment response at 6 months' follow-up assessed using both the absolute change in 28-joint count Disease Activity Score (DAS28) and the European League Against Rheumatism (EULAR) response criteria. Analyses were performed across subgroups comprising etanercept-, infliximab- and infliximab/adalimumab-treated patients as well as the combined anti-TNF-treated cohort. p Values

Original language	English
Pages (from-to)	1315-1320
Number of pages	5
Journal	Annals of the rheumatic diseases
Volume	69
Issue number	7
DOIs	https://doi.org/10.1136/ard.2009.117309
Publication status	Published - Jul 2010

Access to Document

10.1136/ard.2009.117309

http://ard.bmj.com/content/69/7/1315.full.pdf

Cite this

@article{a476bc2ca8354bb3aa064add2eaee5cc,

title = "Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NFκB signalling pathways",

abstract = "Objective: To determine whether genetic variation within genes integral to the Toll-like receptor (TLR) and NFκB signalling systems, two cardinal regulators of inflammatory and immune responses, contributes towards the observed variation in response to tumour necrosis factor (TNF) blocking agents in patients with rheumatoid arthritis (RA). Methods: Pairwise-tagging single nucleotide polymorphisms (SNPs) spanning 24 candidate genes were selected and genotyped in a large UK cohort of patients receiving anti-TNF therapy for RA. Multivariate regression analyses were performed to test association between individual genotypes, under an additive model, and treatment response at 6 months' follow-up assessed using both the absolute change in 28-joint count Disease Activity Score (DAS28) and the European League Against Rheumatism (EULAR) response criteria. Analyses were performed across subgroups comprising etanercept-, infliximab- and infliximab/adalimumab-treated patients as well as the combined anti-TNF-treated cohort. p Values",

author = "Catherine Potter and Cordell, {Heather J.} and Anne Barton and Daly, {Ann K.} and Hyrich, {Kimme L.} and Mann, {Derek A.} and Morgan, {Ann W.} and Wilson, {Anthony G.} and Isaacs, {John D.}",

year = "2010",

month = jul,

doi = "10.1136/ard.2009.117309",

language = "English",

volume = "69",

pages = "1315--1320",

journal = "Annals of the rheumatic diseases",

issn = "0003-4967",

publisher = "BMJ ",

number = "7",

}

TY - JOUR

T1 - Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NFκB signalling pathways

AU - Potter, Catherine

AU - Cordell, Heather J.

AU - Barton, Anne

AU - Daly, Ann K.

AU - Hyrich, Kimme L.

AU - Mann, Derek A.

AU - Morgan, Ann W.

AU - Wilson, Anthony G.

AU - Isaacs, John D.

PY - 2010/7

Y1 - 2010/7

N2 - Objective: To determine whether genetic variation within genes integral to the Toll-like receptor (TLR) and NFκB signalling systems, two cardinal regulators of inflammatory and immune responses, contributes towards the observed variation in response to tumour necrosis factor (TNF) blocking agents in patients with rheumatoid arthritis (RA). Methods: Pairwise-tagging single nucleotide polymorphisms (SNPs) spanning 24 candidate genes were selected and genotyped in a large UK cohort of patients receiving anti-TNF therapy for RA. Multivariate regression analyses were performed to test association between individual genotypes, under an additive model, and treatment response at 6 months' follow-up assessed using both the absolute change in 28-joint count Disease Activity Score (DAS28) and the European League Against Rheumatism (EULAR) response criteria. Analyses were performed across subgroups comprising etanercept-, infliximab- and infliximab/adalimumab-treated patients as well as the combined anti-TNF-treated cohort. p Values

AB - Objective: To determine whether genetic variation within genes integral to the Toll-like receptor (TLR) and NFκB signalling systems, two cardinal regulators of inflammatory and immune responses, contributes towards the observed variation in response to tumour necrosis factor (TNF) blocking agents in patients with rheumatoid arthritis (RA). Methods: Pairwise-tagging single nucleotide polymorphisms (SNPs) spanning 24 candidate genes were selected and genotyped in a large UK cohort of patients receiving anti-TNF therapy for RA. Multivariate regression analyses were performed to test association between individual genotypes, under an additive model, and treatment response at 6 months' follow-up assessed using both the absolute change in 28-joint count Disease Activity Score (DAS28) and the European League Against Rheumatism (EULAR) response criteria. Analyses were performed across subgroups comprising etanercept-, infliximab- and infliximab/adalimumab-treated patients as well as the combined anti-TNF-treated cohort. p Values

U2 - 10.1136/ard.2009.117309

DO - 10.1136/ard.2009.117309

M3 - Article

C2 - 20448286

VL - 69

SP - 1315

EP - 1320

JO - Annals of the rheumatic diseases

JF - Annals of the rheumatic diseases

SN - 0003-4967

IS - 7

ER -

Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NFκB signalling pathways

Abstract

Access to Document

Fingerprint

Cite this