Association between idiopathic infantile macrocephaly and autism spectrum disorders

Patrick F. Bolton; Melanie Roobol; Lucy Allsopp; Andrew Pickles

doi:10.1016/S0140-6736(01)05903-7

Association between idiopathic infantile macrocephaly and autism spectrum disorders

Patrick F. Bolton, Melanie Roobol, Lucy Allsopp, Andrew Pickles

Research output: Contribution to journal › Article › peer-review

Abstract

We conducted a case-controlled, catch-up study of a cohort of boys born with macrocephaly in order to determine whether infantile macrocephaly is a risk marker for the later development of autism spectrum disorders. Our results show that infantile macrocephaly was associated with an increased risk of developing autism spectrum disorders (odds ratio 5.44, 95% CI 1.11-52.15; p=0.03). These findings suggest that neurobiological differences during infancy may predict behavioural manifestations of autism spectrum disorders.

Original language	English
Pages (from-to)	726-727
Number of pages	1
Journal	The Lancet
Volume	358
Issue number	9283
DOIs	https://doi.org/10.1016/S0140-6736(01)05903-7
Publication status	Published - 1 Sept 2001

Keywords

abnormalities
Autistic Disorder
Case-Control Studies
Cephalometry
Child,Preschool
diagnosis
etiology
Human
Infant
Male
Odds Ratio
Questionnaires
Risk
Skull

Access to Document

10.1016/S0140-6736(01)05903-7

Cite this

@article{dae580bac15e4fe8b6f1521767f0bdbe,

title = "Association between idiopathic infantile macrocephaly and autism spectrum disorders",

abstract = "We conducted a case-controlled, catch-up study of a cohort of boys born with macrocephaly in order to determine whether infantile macrocephaly is a risk marker for the later development of autism spectrum disorders. Our results show that infantile macrocephaly was associated with an increased risk of developing autism spectrum disorders (odds ratio 5.44, 95% CI 1.11-52.15; p=0.03). These findings suggest that neurobiological differences during infancy may predict behavioural manifestations of autism spectrum disorders.",

keywords = "abnormalities, Autistic Disorder, Case-Control Studies, Cephalometry, Child,Preschool, diagnosis, etiology, Human, Infant, Male, Odds Ratio, Questionnaires, Risk, Skull",

author = "Bolton, {Patrick F.} and Melanie Roobol and Lucy Allsopp and Andrew Pickles",

note = "UI - 21436056DA - 20010911IS - 0140-6736LA - engPT - LetterSB - AIMSB - IM",

year = "2001",

month = sep,

day = "1",

doi = "10.1016/S0140-6736(01)05903-7",

language = "English",

volume = "358",

pages = "726--727",

journal = "The Lancet",

issn = "0140-6736",

publisher = "Elsevier BV",

number = "9283",

}

TY - JOUR

T1 - Association between idiopathic infantile macrocephaly and autism spectrum disorders

AU - Bolton, Patrick F.

AU - Roobol, Melanie

AU - Allsopp, Lucy

AU - Pickles, Andrew

N1 - UI - 21436056DA - 20010911IS - 0140-6736LA - engPT - LetterSB - AIMSB - IM

PY - 2001/9/1

Y1 - 2001/9/1

N2 - We conducted a case-controlled, catch-up study of a cohort of boys born with macrocephaly in order to determine whether infantile macrocephaly is a risk marker for the later development of autism spectrum disorders. Our results show that infantile macrocephaly was associated with an increased risk of developing autism spectrum disorders (odds ratio 5.44, 95% CI 1.11-52.15; p=0.03). These findings suggest that neurobiological differences during infancy may predict behavioural manifestations of autism spectrum disorders.

AB - We conducted a case-controlled, catch-up study of a cohort of boys born with macrocephaly in order to determine whether infantile macrocephaly is a risk marker for the later development of autism spectrum disorders. Our results show that infantile macrocephaly was associated with an increased risk of developing autism spectrum disorders (odds ratio 5.44, 95% CI 1.11-52.15; p=0.03). These findings suggest that neurobiological differences during infancy may predict behavioural manifestations of autism spectrum disorders.

KW - abnormalities

KW - Autistic Disorder

KW - Case-Control Studies

KW - Cephalometry

KW - Child,Preschool

KW - diagnosis

KW - etiology

KW - Human

KW - Infant

KW - Male

KW - Odds Ratio

KW - Questionnaires

KW - Risk

KW - Skull

U2 - 10.1016/S0140-6736(01)05903-7

DO - 10.1016/S0140-6736(01)05903-7

M3 - Article

SN - 0140-6736

VL - 358

SP - 726

EP - 727

JO - The Lancet

JF - The Lancet

IS - 9283

ER -

Association between idiopathic infantile macrocephaly and autism spectrum disorders

Abstract

Keywords

Access to Document

Fingerprint

Cite this