Association of cytokine single nucleotide polymorphisms with B7 costimulatory molecules in kidney allograft recipients

A. Hutchings, L. Guay-Woodford, J. M. Thomas, C. J. Young, W. M. Purcell, V. Pravica, C. Perrey, I. V. Hutchinson, M. R. Benfield

    Research output: Contribution to journalArticlepeer-review

    Abstract

    African-American race is associated with an increased risk of allograft loss, suggesting that African-American patients may form an immunologically higher risk group. Previously, we demonstrated that immune cell costimulatory molecule expression is significantly higher in African-Americans than in Caucasians. Polymorphic variations in the genes for cytokines have been associated with a number of immunological conditions, and with transplant rejection. This study was performed to determine the distribution, in African-American and Caucasian renal transplant recipients, of single nucleotide polymorphisms (SNPs) in the following cytokine genes: tumor necrosis factor-α(TNF-α), interferon-γ (IFN-γ) interleukin (IL)-6, IL-10, and transforming growth factor-β (TGF-β). Cytokine production from blood cells was determined, and cell-surface B7 (CD80, CD86) expression was measured. There was a significant link between IL-10 genotype and acute rejection episodes, but only in African-American patients (p
    Original languageEnglish
    Pages (from-to)69-77
    Number of pages8
    JournalPediatric transplantation
    Volume6
    Issue number1
    DOIs
    Publication statusPublished - 2002

    Keywords

    • Genotype
    • Immunology
    • Race
    • Renal transplantation
    • Single nucleotide polymorphisms

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