Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study.

Ervin R Fox; J Hunter Young; Yali Li; Albert W Dreisbach; Brendan J Keating; Solomon K Musani; Kiang Liu; Alanna C Morrison; Santhi Ganesh; Abdullah Kutlar; Vasan S Ramachandran; Josef F Polak; Richard R Fabsitz; Daniel L Dries; Deborah N Farlow; Susan Redline; Adebowale Adeyemo; Joel N Hirschorn; Yan V Sun; Sharon B Wyatt; Alan D Penman; Walter Palmas; Jerome I Rotter; Raymond R Townsend; Ayo P Doumatey; Bamidele O Tayo; Thomas H Mosley; Helen N Lyon; Sun J Kang; Charles N Rotimi; Richard S Cooper; Nora Franceschini; J David Curb; Lisa W Martin; Charles B Eaton; Sharon L R Kardia; Herman A Taylor; Mark J Caulfield; Georg B Ehret; Toby Johnson; Aravinda Chakravarti; Xiaofeng Zhu; Daniel Levy; Patricia B Munroe; Kenneth M Rice; Murielle Bochud; Andrew D Johnson; Daniel I Chasman; Albert V Smith; Martin D Tobin; Germaine C Verwoert; Shih-Jen Hwang; Vasyl Pihur; Peter Vollenweider; Paul F O'Reilly; Najaf Amin; Jennifer L Bragg-Gresham; Alexander Teumer; Nicole L Glazer; Lenore Launer; Jing Hua Zhao; Yurii Aulchenko; Simon Heath; Siim Sõber; Afshin Parsa; Jian'an Luan; Pankaj Arora; Abbas Dehghan; Feng Zhang; Gavin Lucas; Andrew A Hicks; Anne U Jackson; John F Peden; Toshiko Tanaka; Sarah H Wild; Igor Rudan; Wilmar Igl; Yuri Milaneschi; Alex N Parker; Cristiano Fava; John C Chambers; Meena Kumari; Min Jin Go; Pim van der Harst; Wen Hong Linda Kao; Marketa Sjögren; D G Vinay; Myriam Alexander; Yasuharu Tabara; Sue Shaw-Hawkins; Peter H Whincup; Yongmei Liu; Gang Shi; Johanna Kuusisto; Mark Seielstad; Xueling Sim; Khanh-Dung Hoang Nguyen; Terho Lehtimäki; Giuseppe Matullo; Ying Wu; Tom R Gaunt; N Charlotte Onland-Moret; Matthew N Cooper; Carl G P Platou; Elin Org; Rebecca Hardy; Santosh Dahgam; Jutta Palmen; Veronique Vitart; Peter S Braund; Tatiana Kuznetsova; Cuno S P M Uiterwaal; Harry Campbell; Barbara Ludwig; Maciej Tomaszewski; Ioanna Tzoulaki; Nicholette D Palmer; [Unknown] CARDIoGRAM consortium; [Unknown] CKDGen consortium; [Unknown] KidneyGen consortium; [Unknown] EchoGen consortium; [Unknown] CHARGE-HF consortium; Thor Aspelund; Melissa Garcia; Yen-Pei C Chang; Jeffrey R O'Connell; Nanette I Steinle; Diederick E Grobbee; Dan E Arking; Dena Hernandez; Samer Najjar; Wendy L McArdle; David Hadley; Morris J Brown; John M Connell; Aroon D Hingorani; Ian N M Day; Debbie A Lawlor; John P Beilby; Robert W Lawrence; Robert Clarke; Rory Collins; Jemma C Hopewell; Halit Ongen; Joshua C Bis; Mika Kähönen; Jorma Viikari; Linda S Adair; Nanette R Lee; Ming-Huei Chen; Matthias Olden; Cristian Pattaro; Judith A Hoffman Bolton; Anna Köttgen; Sven Bergmann; Vincent Mooser; Nish Chaturvedi; Timothy M Frayling; Muhammad Islam; Tazeen H Jafar; Jeanette Erdmann; Smita R Kulkarni; Stefan R Bornstein; Jürgen Grässler; Leif Groop; Benjamin F Voight; Johannes Kettunen; Philip Howard; Andrew Taylor; Simonetta Guarrera; Fulvio Ricceri; Valur Emilsson; Andrew Plump; Inês Barroso; Kay-Tee Khaw; Alan B Weder; Steven C Hunt; Richard N Bergman; Francis S Collins; Lori L Bonnycastle; Laura J Scott; Heather M Stringham; Leena Peltonen; Markus Perola; Erkki Vartiainen; Stefan-Martin Brand; Jan A Staessen; Thomas J Wang; Paul R Burton; Maria Soler Artigas; Yanbin Dong; Harold Snieder; Xiaoling Wang; Haidong Zhu; Kurt K Lohman; Megan E Rudock; Susan R Heckbert; Nicholas L Smith; Kerri L Wiggins; Daniel Shriner; Gudrun Veldre; Margus Viigimaa; Sanjay Kinra; Dorairajan Prabhakaran; Vikal Tripathy; Carl D Langefeld; Annika Rosengren; Dag S Thelle; Anna Maria Corsi; Andrew Singleton; Terrence Forrester; Gina Hilton; Colin A McKenzie; Tunde Salako; Naoharu Iwai; Yoshikuni Kita; Toshio Ogihara; Takayoshi Ohkubo; Tomonori Okamura; Hirotsugu Ueshima; Satoshi Umemura; Susana Eyheramendy; Thomas Meitinger; H-Erich Wichmann; Yoon Shin Cho; Hyung-Lae Kim; Jong-Young Lee; James Scott; Joban S Sehmi; Weihua Zhang; Bo Hedblad; Peter Nilsson; George Davey Smith; Andrew Wong; Narisu Narisu; Alena Stancáková; Leslie J Raffel; Jie Yao; Sekar Kathiresan; Chris O'Donnell; Steven M Schwartz; M Arfan Ikram; Will T Longstreth; Sudha Seshadri; Nick R G Shrine; Louise V Wain; Mario A Morken; Amy J Swift; Jaana Laitinen; Inga Prokopenko; Paavo Zitting; Jackie A Cooper; Steve E Humphries; John Danesh; Asif Rasheed; Anuj oel; Anders Hamsten; Hugh Watkins; Stephan J L Bakker; Wiek H van Gilst; Charles S Janipalli; K Radha Mani; Chittaranjan S Yajnik; Albert Hofman; Francesco U S Mattace-Raso; Ben A Oostra; Ayse Demirkan; Aaron Isaacs; Fernando Rivadeneira; Edward G Lakatta; Marco Orru; Angelo Scuteri; Mika Ala-Korpela; Antti J Kangas; Leo-Pekka Lyytikäinen; Pasi Soininen; Taru Tukiainen; Peter Würz; Rick Twee-Hee Ong; Marcus Dörr; Heyo K Kroemer; Uwe Völker; Henry Völzke; Pilar Galan; Serge Hercberg; Mark Lathrop; Diana Zelenika; Panos Deloukas; Massimo Mangino; Tim D Spector; Guangju Zhai; James F Meschia; Michael A Nalls; Pankaj Sharma; Janos Terzic; M J Kranthi Kumar; Matthew Denniff; Ewa Zukowska-Szczechowska; Lynne E Wagenknecht; F Gerald R Fowkes; Fadi J Charchar; Peter E H Schwarz; Caroline Hayward; Xiuqing Guo; Michiel L Bots; Eva Brand; Nilesh J Samani; Ozren Polasek; Philippa J Talmud; Fredrik Nyberg; Diana Kuh; Maris Laan; Kristian Hveem; Lyle J Palmer; Yvonne T van der Schouw; Juan P Casas; Karen L Mohlke; Paolo Vineis; Olli Raitakari; Tien Y Wong; E Shyong Tai; Markku Laakso; Dabeeru C Rao; Tamara B Harris; Richard W Morris; Anna F Dominiczak; Mika Kivimaki; Michael G Marmot; Tetsuro Miki; Danish Saleheen; Giriraj R Chandak; Josef Coresh; Gerjan Navis; Veikko Salomaa; Bok-Ghee Han; Jaspal S Kooner; Olle Melander; Paul M Ridker; Stefania Bandinelli; Ulf B Gyllensten; Alan F Wright; James F Wilson; Luigi Ferrucci; Martin Farrall; Jaakko Tuomilehto; Peter P Pramstaller; Roberto Elosua; Nicole Soranzo; Eric J G Sijbrands; David Altshuler; Ruth J F Loos; Alan R Shuldiner; Christian Gieger; Pierre Meneton; Andre G Uitterlinden; Nicholas J Wareham; Vilmundur Gudnason; Rainer Rettig; Manuela Uda; David P Strachan; Jacqueline C M Witteman; Anna Liisa Hartikainen; Jacques S Beckmann; Eric Boerwinkle; Michael Boehnke; Martin G Larson; Marjo-Riitt Järvelin; Bruce M Psaty; Gonçalo R Abecasis; Paul Elliott; Cornelia M van Duijn; Christopher Newton-Cheh

doi:10.1093/hmg/ddr092

Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study.

Ervin R Fox, J Hunter Young, Yali Li, Albert W Dreisbach, Brendan J Keating, Solomon K Musani, Kiang Liu, Alanna C Morrison, Santhi Ganesh, Abdullah Kutlar, Vasan S Ramachandran, Josef F Polak, Richard R Fabsitz, Daniel L Dries, Deborah N Farlow, Susan Redline, Adebowale Adeyemo, Joel N Hirschorn, Yan V Sun, Sharon B WyattAlan D Penman, Walter Palmas, Jerome I Rotter, Raymond R Townsend, Ayo P Doumatey, Bamidele O Tayo, Thomas H Mosley, Helen N Lyon, Sun J Kang, Charles N Rotimi, Richard S Cooper, Nora Franceschini, J David Curb, Lisa W Martin, Charles B Eaton, Sharon L R Kardia, Herman A Taylor, Mark J Caulfield, Georg B Ehret, Toby Johnson, Aravinda Chakravarti, Xiaofeng Zhu, Daniel Levy, Patricia B Munroe (Collaborator), Kenneth M Rice (Collaborator), Murielle Bochud (Collaborator), Andrew D Johnson (Collaborator), Daniel I Chasman (Collaborator), Albert V Smith (Collaborator), Martin D Tobin (Collaborator), Germaine C Verwoert (Collaborator), Shih-Jen Hwang (Collaborator), Vasyl Pihur (Collaborator), Peter Vollenweider (Collaborator), Paul F O'Reilly (Collaborator), Najaf Amin (Collaborator), Jennifer L Bragg-Gresham (Collaborator), Alexander Teumer (Collaborator), Nicole L Glazer (Collaborator), Lenore Launer (Collaborator), Jing Hua Zhao (Collaborator), Yurii Aulchenko (Collaborator), Simon Heath (Collaborator), Siim Sõber (Collaborator), Afshin Parsa (Collaborator), Jian'an Luan (Collaborator), Pankaj Arora (Collaborator), Abbas Dehghan (Collaborator), Feng Zhang (Collaborator), Gavin Lucas (Collaborator), Andrew A Hicks (Collaborator), Anne U Jackson (Collaborator), John F Peden (Collaborator), Toshiko Tanaka (Collaborator), Sarah H Wild (Collaborator), Igor Rudan (Collaborator), Wilmar Igl (Collaborator), Yuri Milaneschi (Collaborator), Alex N Parker (Collaborator), Cristiano Fava (Collaborator), John C Chambers (Collaborator), Meena Kumari (Collaborator), Min Jin Go (Collaborator), Pim van der Harst (Collaborator), Wen Hong Linda Kao (Collaborator), Marketa Sjögren (Collaborator), D G Vinay (Collaborator), Myriam Alexander (Collaborator), Yasuharu Tabara (Collaborator), Sue Shaw-Hawkins (Collaborator), Peter H Whincup (Collaborator), Yongmei Liu (Collaborator), Gang Shi (Collaborator), Johanna Kuusisto (Collaborator), Mark Seielstad (Collaborator), Xueling Sim (Collaborator), Khanh-Dung Hoang Nguyen (Collaborator), Terho Lehtimäki (Collaborator), Giuseppe Matullo (Collaborator), Ying Wu (Collaborator), Tom R Gaunt (Collaborator), N Charlotte Onland-Moret (Collaborator), Matthew N Cooper (Collaborator), Carl G P Platou (Collaborator), Elin Org (Collaborator), Rebecca Hardy (Collaborator), Santosh Dahgam (Collaborator), Jutta Palmen (Collaborator), Veronique Vitart (Collaborator), Peter S Braund (Collaborator), Tatiana Kuznetsova (Collaborator), Cuno S P M Uiterwaal (Collaborator), Harry Campbell (Collaborator), Barbara Ludwig (Collaborator), Maciej Tomaszewski (Collaborator), Ioanna Tzoulaki (Collaborator), Nicholette D Palmer (Collaborator), [Unknown] CARDIoGRAM consortium (Collaborator), [Unknown] CKDGen consortium (Collaborator), [Unknown] KidneyGen consortium (Collaborator), [Unknown] EchoGen consortium (Collaborator), [Unknown] CHARGE-HF consortium (Collaborator), Thor Aspelund (Collaborator), Melissa Garcia (Collaborator), Yen-Pei C Chang (Collaborator), Jeffrey R O'Connell (Collaborator), Nanette I Steinle (Collaborator), Diederick E Grobbee (Collaborator), Dan E Arking (Collaborator), Dena Hernandez (Collaborator), Samer Najjar (Collaborator), Wendy L McArdle (Collaborator), David Hadley (Collaborator), Morris J Brown (Collaborator), John M Connell (Collaborator), Aroon D Hingorani (Collaborator), Ian N M Day (Collaborator), Debbie A Lawlor (Collaborator), John P Beilby (Collaborator), Robert W Lawrence (Collaborator), Robert Clarke (Collaborator), Rory Collins (Collaborator), Jemma C Hopewell (Collaborator), Halit Ongen (Collaborator), Joshua C Bis (Collaborator), Mika Kähönen (Collaborator), Jorma Viikari (Collaborator), Linda S Adair (Collaborator), Nanette R Lee (Collaborator), Ming-Huei Chen (Collaborator), Matthias Olden (Collaborator), Cristian Pattaro (Collaborator), Judith A Hoffman Bolton (Collaborator), Anna Köttgen (Collaborator), Sven Bergmann (Collaborator), Vincent Mooser (Collaborator), Nish Chaturvedi (Collaborator), Timothy M Frayling (Collaborator), Muhammad Islam (Collaborator), Tazeen H Jafar (Collaborator), Jeanette Erdmann (Collaborator), Smita R Kulkarni (Collaborator), Stefan R Bornstein (Collaborator), Jürgen Grässler (Collaborator), Leif Groop (Collaborator), Benjamin F Voight (Collaborator), Johannes Kettunen (Collaborator), Philip Howard (Collaborator), Andrew Taylor (Collaborator), Simonetta Guarrera (Collaborator), Fulvio Ricceri (Collaborator), Valur Emilsson (Collaborator), Andrew Plump (Collaborator), Inês Barroso (Collaborator), Kay-Tee Khaw (Collaborator), Alan B Weder (Collaborator), Steven C Hunt (Collaborator), Richard N Bergman (Collaborator), Francis S Collins (Collaborator), Lori L Bonnycastle (Collaborator), Laura J Scott (Collaborator), Heather M Stringham (Collaborator), Leena Peltonen (Collaborator), Markus Perola (Collaborator), Erkki Vartiainen (Collaborator), Stefan-Martin Brand (Collaborator), Jan A Staessen (Collaborator), Thomas J Wang (Collaborator), Paul R Burton (Collaborator), Maria Soler Artigas (Collaborator), Yanbin Dong (Collaborator), Harold Snieder (Collaborator), Xiaoling Wang (Collaborator), Haidong Zhu (Collaborator), Kurt K Lohman (Collaborator), Megan E Rudock (Collaborator), Susan R Heckbert (Collaborator), Nicholas L Smith (Collaborator), Kerri L Wiggins (Collaborator), Daniel Shriner (Collaborator), Gudrun Veldre (Collaborator), Margus Viigimaa (Collaborator), Sanjay Kinra (Collaborator), Dorairajan Prabhakaran (Collaborator), Vikal Tripathy (Collaborator), Carl D Langefeld (Collaborator), Annika Rosengren (Collaborator), Dag S Thelle (Collaborator), Anna Maria Corsi (Collaborator), Andrew Singleton (Collaborator), Terrence Forrester (Collaborator), Gina Hilton (Collaborator), Colin A McKenzie (Collaborator), Tunde Salako (Collaborator), Naoharu Iwai (Collaborator), Yoshikuni Kita (Collaborator), Toshio Ogihara (Collaborator), Takayoshi Ohkubo (Collaborator), Tomonori Okamura (Collaborator), Hirotsugu Ueshima (Collaborator), Satoshi Umemura (Collaborator), Susana Eyheramendy (Collaborator), Thomas Meitinger (Collaborator), H-Erich Wichmann (Collaborator), Yoon Shin Cho (Collaborator), Hyung-Lae Kim (Collaborator), Jong-Young Lee (Collaborator), James Scott (Collaborator), Joban S Sehmi (Collaborator), Weihua Zhang (Collaborator), Bo Hedblad (Collaborator), Peter Nilsson (Collaborator), George Davey Smith (Collaborator), Andrew Wong (Collaborator), Narisu Narisu (Collaborator), Alena Stancáková (Collaborator), Leslie J Raffel (Collaborator), Jie Yao (Collaborator), Sekar Kathiresan (Collaborator), Chris O'Donnell (Collaborator), Steven M Schwartz (Collaborator), M Arfan Ikram (Collaborator), Will T Longstreth (Collaborator), Sudha Seshadri (Collaborator), Nick R G Shrine (Collaborator), Louise V Wain (Collaborator), Mario A Morken (Collaborator), Amy J Swift (Collaborator), Jaana Laitinen (Collaborator), Inga Prokopenko (Collaborator), Paavo Zitting (Collaborator), Jackie A Cooper (Collaborator), Steve E Humphries (Collaborator), John Danesh (Collaborator), Asif Rasheed (Collaborator), Anuj oel (Collaborator), Anders Hamsten (Collaborator), Hugh Watkins (Collaborator), Stephan J L Bakker (Collaborator), Wiek H van Gilst (Collaborator), Charles S Janipalli (Collaborator), K Radha Mani (Collaborator), Chittaranjan S Yajnik (Collaborator), Albert Hofman (Collaborator), Francesco U S Mattace-Raso (Collaborator), Ben A Oostra (Collaborator), Ayse Demirkan (Collaborator), Aaron Isaacs (Collaborator), Fernando Rivadeneira (Collaborator), Edward G Lakatta (Collaborator), Marco Orru (Collaborator), Angelo Scuteri (Collaborator), Mika Ala-Korpela (Collaborator), Antti J Kangas (Collaborator), Leo-Pekka Lyytikäinen (Collaborator), Pasi Soininen (Collaborator), Taru Tukiainen (Collaborator), Peter Würz (Collaborator), Rick Twee-Hee Ong (Collaborator), Marcus Dörr (Collaborator), Heyo K Kroemer (Collaborator), Uwe Völker (Collaborator), Henry Völzke (Collaborator), Pilar Galan (Collaborator), Serge Hercberg (Collaborator), Mark Lathrop (Collaborator), Diana Zelenika (Collaborator), Panos Deloukas (Collaborator), Massimo Mangino (Collaborator), Tim D Spector (Collaborator), Guangju Zhai (Collaborator), James F Meschia (Collaborator), Michael A Nalls (Collaborator), Pankaj Sharma (Collaborator), Janos Terzic (Collaborator), M J Kranthi Kumar (Collaborator), Matthew Denniff (Collaborator), Ewa Zukowska-Szczechowska (Collaborator), Lynne E Wagenknecht (Collaborator), F Gerald R Fowkes (Collaborator), Fadi J Charchar (Collaborator), Peter E H Schwarz (Collaborator), Caroline Hayward (Collaborator), Xiuqing Guo (Collaborator), Michiel L Bots (Collaborator), Eva Brand (Collaborator), Nilesh J Samani (Collaborator), Ozren Polasek (Collaborator), Philippa J Talmud (Collaborator), Fredrik Nyberg (Collaborator), Diana Kuh (Collaborator), Maris Laan (Collaborator), Kristian Hveem (Collaborator), Lyle J Palmer (Collaborator), Yvonne T van der Schouw (Collaborator), Juan P Casas (Collaborator), Karen L Mohlke (Collaborator), Paolo Vineis (Collaborator), Olli Raitakari (Collaborator), Tien Y Wong (Collaborator), E Shyong Tai (Collaborator), Markku Laakso (Collaborator), Dabeeru C Rao (Collaborator), Tamara B Harris (Collaborator), Richard W Morris (Collaborator), Anna F Dominiczak (Collaborator), Mika Kivimaki (Collaborator), Michael G Marmot (Collaborator), Tetsuro Miki (Collaborator), Danish Saleheen (Collaborator), Giriraj R Chandak (Collaborator), Josef Coresh (Collaborator), Gerjan Navis (Collaborator), Veikko Salomaa (Collaborator), Bok-Ghee Han (Collaborator), Jaspal S Kooner (Collaborator), Olle Melander (Collaborator), Paul M Ridker (Collaborator), Stefania Bandinelli (Collaborator), Ulf B Gyllensten (Collaborator), Alan F Wright (Collaborator), James F Wilson (Collaborator), Luigi Ferrucci (Collaborator), Martin Farrall (Collaborator), Jaakko Tuomilehto (Collaborator), Peter P Pramstaller (Collaborator), Roberto Elosua (Collaborator), Nicole Soranzo (Collaborator), Eric J G Sijbrands (Collaborator), David Altshuler (Collaborator), Ruth J F Loos (Collaborator), Alan R Shuldiner (Collaborator), Christian Gieger (Collaborator), Pierre Meneton (Collaborator), Andre G Uitterlinden (Collaborator), Nicholas J Wareham (Collaborator), Vilmundur Gudnason (Collaborator), Rainer Rettig (Collaborator), Manuela Uda (Collaborator), David P Strachan (Collaborator), Jacqueline C M Witteman (Collaborator), Anna Liisa Hartikainen (Collaborator), Jacques S Beckmann (Collaborator), Eric Boerwinkle (Collaborator), Michael Boehnke (Collaborator), Martin G Larson (Collaborator), Marjo-Riitt Järvelin (Collaborator), Bruce M Psaty (Collaborator), Gonçalo R Abecasis (Collaborator), Paul Elliott (Collaborator), Cornelia M van Duijn (Collaborator), Christopher Newton-Cheh (Collaborator)

Research output: Contribution to journal › Article › peer-review

Abstract

The prevalence of hypertension in African Americans (AAs) is higher than in other US groups; yet, few have performed genome-wide association studies (GWASs) in AA. Among people of European descent, GWASs have identified genetic variants at 13 loci that are associated with blood pressure. It is unknown if these variants confer susceptibility in people of African ancestry. Here, we examined genome-wide and candidate gene associations with systolic blood pressure (SBP) and diastolic blood pressure (DBP) using the Candidate Gene Association Resource (CARe) consortium consisting of 8591 AAs. Genotypes included genome-wide single-nucleotide polymorphism (SNP) data utilizing the Affymetrix 6.0 array with imputation to 2.5 million HapMap SNPs and candidate gene SNP data utilizing a 50K cardiovascular gene-centric array (ITMAT-Broad-CARe [IBC] array). For Affymetrix data, the strongest signal for DBP was rs10474346 (P= 3.6 × 10(-8)) located near GPR98 and ARRDC3. For SBP, the strongest signal was rs2258119 in C21orf91 (P= 4.7 × 10(-8)). The top IBC association for SBP was rs2012318 (P= 6.4 × 10(-6)) near SLC25A42 and for DBP was rs2523586 (P= 1.3 × 10(-6)) near HLA-B. None of the top variants replicated in additional AA (n = 11 882) or European-American (n = 69 899) cohorts. We replicated previously reported European-American blood pressure SNPs in our AA samples (SH2B3, P= 0.009; TBX3-TBX5, P= 0.03; and CSK-ULK3, P= 0.0004). These genetic loci represent the best evidence of genetic influences on SBP and DBP in AAs to date. More broadly, this work supports that notion that blood pressure among AAs is a trait with genetic underpinnings but also with significant complexity.

Original language	English
Journal	Human Molecular Genetics
Volume	20
Issue number	11
DOIs	https://doi.org/10.1093/hmg/ddr092
Publication status	Published - 1 Jun 2011

Access to Document

10.1093/hmg/ddr092

Cite this

Fox, E. R., Young, J. H., Li, Y., Dreisbach, A. W., Keating, B. J., Musani, S. K., Liu, K., Morrison, A. C., Ganesh, S., Kutlar, A., Ramachandran, V. S., Polak, J. F., Fabsitz, R. R., Dries, D. L., Farlow, D. N., Redline, S., Adeyemo, A., Hirschorn, J. N., Sun, Y. V., ... Newton-Cheh, C. (2011). Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study. Human Molecular Genetics, 20(11). https://doi.org/10.1093/hmg/ddr092

@article{655e4e965d964672be70aafb53ad1b67,

title = "Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study.",

abstract = "The prevalence of hypertension in African Americans (AAs) is higher than in other US groups; yet, few have performed genome-wide association studies (GWASs) in AA. Among people of European descent, GWASs have identified genetic variants at 13 loci that are associated with blood pressure. It is unknown if these variants confer susceptibility in people of African ancestry. Here, we examined genome-wide and candidate gene associations with systolic blood pressure (SBP) and diastolic blood pressure (DBP) using the Candidate Gene Association Resource (CARe) consortium consisting of 8591 AAs. Genotypes included genome-wide single-nucleotide polymorphism (SNP) data utilizing the Affymetrix 6.0 array with imputation to 2.5 million HapMap SNPs and candidate gene SNP data utilizing a 50K cardiovascular gene-centric array (ITMAT-Broad-CARe [IBC] array). For Affymetrix data, the strongest signal for DBP was rs10474346 (P= 3.6 × 10(-8)) located near GPR98 and ARRDC3. For SBP, the strongest signal was rs2258119 in C21orf91 (P= 4.7 × 10(-8)). The top IBC association for SBP was rs2012318 (P= 6.4 × 10(-6)) near SLC25A42 and for DBP was rs2523586 (P= 1.3 × 10(-6)) near HLA-B. None of the top variants replicated in additional AA (n = 11 882) or European-American (n = 69 899) cohorts. We replicated previously reported European-American blood pressure SNPs in our AA samples (SH2B3, P= 0.009; TBX3-TBX5, P= 0.03; and CSK-ULK3, P= 0.0004). These genetic loci represent the best evidence of genetic influences on SBP and DBP in AAs to date. More broadly, this work supports that notion that blood pressure among AAs is a trait with genetic underpinnings but also with significant complexity.",

author = "Fox, \{Ervin R\} and Young, \{J Hunter\} and Yali Li and Dreisbach, \{Albert W\} and Keating, \{Brendan J\} and Musani, \{Solomon K\} and Kiang Liu and Morrison, \{Alanna C\} and Santhi Ganesh and Abdullah Kutlar and Ramachandran, \{Vasan S\} and Polak, \{Josef F\} and Fabsitz, \{Richard R\} and Dries, \{Daniel L\} and Farlow, \{Deborah N\} and Susan Redline and Adebowale Adeyemo and Hirschorn, \{Joel N\} and Sun, \{Yan V\} and Wyatt, \{Sharon B\} and Penman, \{Alan D\} and Walter Palmas and Rotter, \{Jerome I\} and Townsend, \{Raymond R\} and Doumatey, \{Ayo P\} and Tayo, \{Bamidele O\} and Mosley, \{Thomas H\} and Lyon, \{Helen N\} and Kang, \{Sun J\} and Rotimi, \{Charles N\} and Cooper, \{Richard S\} and Nora Franceschini and Curb, \{J David\} and Martin, \{Lisa W\} and Eaton, \{Charles B\} and Kardia, \{Sharon L R\} and Taylor, \{Herman A\} and Caulfield, \{Mark J\} and Ehret, \{Georg B\} and Toby Johnson and Aravinda Chakravarti and Xiaofeng Zhu and Daniel Levy and Munroe, \{Patricia B\} and Rice, \{Kenneth M\} and Murielle Bochud and Johnson, \{Andrew D\} and Chasman, \{Daniel I\} and Smith, \{Albert V\} and Tobin, \{Martin D\} and Verwoert, \{Germaine C\} and Shih-Jen Hwang and Vasyl Pihur and Peter Vollenweider and O'Reilly, \{Paul F\} and Najaf Amin and Bragg-Gresham, \{Jennifer L\} and Alexander Teumer and Glazer, \{Nicole L\} and Lenore Launer and Zhao, \{Jing Hua\} and Yurii Aulchenko and Simon Heath and Siim S{\~o}ber and Afshin Parsa and Jian'an Luan and Pankaj Arora and Abbas Dehghan and Feng Zhang and Gavin Lucas and Hicks, \{Andrew A\} and Jackson, \{Anne U\} and Peden, \{John F\} and Toshiko Tanaka and Wild, \{Sarah H\} and Igor Rudan and Wilmar Igl and Yuri Milaneschi and Parker, \{Alex N\} and Cristiano Fava and Chambers, \{John C\} and Meena Kumari and Go, \{Min Jin\} and \{van der Harst\}, Pim and Kao, \{Wen Hong Linda\} and Marketa Sj{\"o}gren and Vinay, \{D G\} and Myriam Alexander and Yasuharu Tabara and Sue Shaw-Hawkins and Whincup, \{Peter H\} and Yongmei Liu and Gang Shi and Johanna Kuusisto and Mark Seielstad and Xueling Sim and Nguyen, \{Khanh-Dung Hoang\} and Terho Lehtim{\"a}ki and Giuseppe Matullo and Ying Wu and Gaunt, \{Tom R\} and Onland-Moret, \{N Charlotte\} and Cooper, \{Matthew N\} and Platou, \{Carl G P\} and Elin Org and Rebecca Hardy and Santosh Dahgam and Jutta Palmen and Veronique Vitart and Braund, \{Peter S\} and Tatiana Kuznetsova and Uiterwaal, \{Cuno S P M\} and Harry Campbell and Barbara Ludwig and Maciej Tomaszewski and Ioanna Tzoulaki and Palmer, \{Nicholette D\} and \{CARDIoGRAM consortium\}, [Unknown] and \{CKDGen consortium\}, [Unknown] and \{KidneyGen consortium\}, [Unknown] and \{EchoGen consortium\}, [Unknown] and \{CHARGE-HF consortium\}, [Unknown] and Thor Aspelund and Melissa Garcia and Chang, \{Yen-Pei C\} and O'Connell, \{Jeffrey R\} and Steinle, \{Nanette I\} and Grobbee, \{Diederick E\} and Arking, \{Dan E\} and Dena Hernandez and Samer Najjar and McArdle, \{Wendy L\} and David Hadley and Brown, \{Morris J\} and Connell, \{John M\} and Hingorani, \{Aroon D\} and Day, \{Ian N M\} and Lawlor, \{Debbie A\} and Beilby, \{John P\} and Lawrence, \{Robert W\} and Robert Clarke and Rory Collins and Hopewell, \{Jemma C\} and Halit Ongen and Bis, \{Joshua C\} and Mika K{\"a}h{\"o}nen and Jorma Viikari and Adair, \{Linda S\} and Lee, \{Nanette R\} and Ming-Huei Chen and Matthias Olden and Cristian Pattaro and \{Hoffman Bolton\}, \{Judith A\} and Anna K{\"o}ttgen and Sven Bergmann and Vincent Mooser and Nish Chaturvedi and Frayling, \{Timothy M\} and Muhammad Islam and Jafar, \{Tazeen H\} and Jeanette Erdmann and Kulkarni, \{Smita R\} and Bornstein, \{Stefan R\} and J{\"u}rgen Gr{\"a}ssler and Leif Groop and Voight, \{Benjamin F\} and Johannes Kettunen and Philip Howard and Andrew Taylor and Simonetta Guarrera and Fulvio Ricceri and Valur Emilsson and Andrew Plump and In{\^e}s Barroso and Kay-Tee Khaw and Weder, \{Alan B\} and Hunt, \{Steven C\} and Bergman, \{Richard N\} and Collins, \{Francis S\} and Bonnycastle, \{Lori L\} and Scott, \{Laura J\} and Stringham, \{Heather M\} and Leena Peltonen and Markus Perola and Erkki Vartiainen and Stefan-Martin Brand and Staessen, \{Jan A\} and Wang, \{Thomas J\} and Burton, \{Paul R\} and \{Soler Artigas\}, Maria and Yanbin Dong and Harold Snieder and Xiaoling Wang and Haidong Zhu and Lohman, \{Kurt K\} and Rudock, \{Megan E\} and Heckbert, \{Susan R\} and Smith, \{Nicholas L\} and Wiggins, \{Kerri L\} and Daniel Shriner and Gudrun Veldre and Margus Viigimaa and Sanjay Kinra and Dorairajan Prabhakaran and Vikal Tripathy and Langefeld, \{Carl D\} and Annika Rosengren and Thelle, \{Dag S\} and Corsi, \{Anna Maria\} and Andrew Singleton and Terrence Forrester and Gina Hilton and McKenzie, \{Colin A\} and Tunde Salako and Naoharu Iwai and Yoshikuni Kita and Toshio Ogihara and Takayoshi Ohkubo and Tomonori Okamura and Hirotsugu Ueshima and Satoshi Umemura and Susana Eyheramendy and Thomas Meitinger and H-Erich Wichmann and Cho, \{Yoon Shin\} and Hyung-Lae Kim and Jong-Young Lee and James Scott and Sehmi, \{Joban S\} and Weihua Zhang and Bo Hedblad and Peter Nilsson and Smith, \{George Davey\} and Andrew Wong and Narisu Narisu and Alena Stanc{\'a}kov{\'a} and Raffel, \{Leslie J\} and Jie Yao and Sekar Kathiresan and Chris O'Donnell and Schwartz, \{Steven M\} and Ikram, \{M Arfan\} and Longstreth, \{Will T\} and Sudha Seshadri and Shrine, \{Nick R G\} and Wain, \{Louise V\} and Morken, \{Mario A\} and Swift, \{Amy J\} and Jaana Laitinen and Inga Prokopenko and Paavo Zitting and Cooper, \{Jackie A\} and Humphries, \{Steve E\} and John Danesh and Asif Rasheed and Anuj oel and Anders Hamsten and Hugh Watkins and Bakker, \{Stephan J L\} and \{van Gilst\}, \{Wiek H\} and Janipalli, \{Charles S\} and Mani, \{K Radha\} and Yajnik, \{Chittaranjan S\} and Albert Hofman and Mattace-Raso, \{Francesco U S\} and Oostra, \{Ben A\} and Ayse Demirkan and Aaron Isaacs and Fernando Rivadeneira and Lakatta, \{Edward G\} and Marco Orru and Angelo Scuteri and Mika Ala-Korpela and Kangas, \{Antti J\} and Leo-Pekka Lyytik{\"a}inen and Pasi Soininen and Taru Tukiainen and Peter W{\"u}rz and Ong, \{Rick Twee-Hee\} and Marcus D{\"o}rr and Kroemer, \{Heyo K\} and Uwe V{\"o}lker and Henry V{\"o}lzke and Pilar Galan and Serge Hercberg and Mark Lathrop and Diana Zelenika and Panos Deloukas and Massimo Mangino and Spector, \{Tim D\} and Guangju Zhai and Meschia, \{James F\} and Nalls, \{Michael A\} and Pankaj Sharma and Janos Terzic and Kumar, \{M J Kranthi\} and Matthew Denniff and Ewa Zukowska-Szczechowska and Wagenknecht, \{Lynne E\} and Fowkes, \{F Gerald R\} and Charchar, \{Fadi J\} and Schwarz, \{Peter E H\} and Caroline Hayward and Xiuqing Guo and Bots, \{Michiel L\} and Eva Brand and Samani, \{Nilesh J\} and Ozren Polasek and Talmud, \{Philippa J\} and Fredrik Nyberg and Diana Kuh and Maris Laan and Kristian Hveem and Palmer, \{Lyle J\} and \{van der Schouw\}, \{Yvonne T\} and Casas, \{Juan P\} and Mohlke, \{Karen L\} and Paolo Vineis and Olli Raitakari and Wong, \{Tien Y\} and Tai, \{E Shyong\} and Markku Laakso and Rao, \{Dabeeru C\} and Harris, \{Tamara B\} and Morris, \{Richard W\} and Dominiczak, \{Anna F\} and Mika Kivimaki and Marmot, \{Michael G\} and Tetsuro Miki and Danish Saleheen and Chandak, \{Giriraj R\} and Josef Coresh and Gerjan Navis and Veikko Salomaa and Bok-Ghee Han and Kooner, \{Jaspal S\} and Olle Melander and Ridker, \{Paul M\} and Stefania Bandinelli and Gyllensten, \{Ulf B\} and Wright, \{Alan F\} and Wilson, \{James F\} and Luigi Ferrucci and Martin Farrall and Jaakko Tuomilehto and Pramstaller, \{Peter P\} and Roberto Elosua and Nicole Soranzo and Sijbrands, \{Eric J G\} and David Altshuler and Loos, \{Ruth J F\} and Shuldiner, \{Alan R\} and Christian Gieger and Pierre Meneton and Uitterlinden, \{Andre G\} and Wareham, \{Nicholas J\} and Vilmundur Gudnason and Rainer Rettig and Manuela Uda and Strachan, \{David P\} and Witteman, \{Jacqueline C M\} and Hartikainen, \{Anna Liisa\} and Beckmann, \{Jacques S\} and Eric Boerwinkle and Michael Boehnke and Larson, \{Martin G\} and Marjo-Riitt J{\"a}rvelin and Psaty, \{Bruce M\} and Abecasis, \{Gon{\c c}alo R\} and Paul Elliott and \{van Duijn\}, \{Cornelia M\} and Christopher Newton-Cheh",

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Medical Research Council, United KingdomMC\_U123092720, Medical Research Council, United KingdomMC\_U123092721, Medical Research Council, United KingdomMC\_U127561128, Medical Research Council, United KingdomMC\_U137686857, Medical Research Council, United KingdomMD002249, NIMHD NIH HHS, United StatesN01 HC-15103, NHLBI NIH HHS, United StatesN01 HC-55222, NHLBI NIH HHS, United StatesN01-HB-72982, NHLBI NIH HHS, United StatesN01-HB-72991, NHLBI NIH HHS, United StatesN01-HB-72992, NHLBI NIH HHS, United StatesN01-HB-72993, NHLBI NIH HHS, United StatesN01-HB-72994, NHLBI NIH HHS, United StatesN01-HB-72995, NHLBI NIH HHS, United StatesN01-HB-72996, NHLBI NIH HHS, United StatesN01-HB-72997, NHLBI NIH HHS, United StatesN01-HB-72998, NHLBI NIH HHS, United StatesN01-HB-73000, NHLBI NIH HHS, United StatesN01-HB-73001, NHLBI NIH HHS, United StatesN01-HB-73002, NHLBI NIH HHS, United StatesN01-HB-73003, NHLBI NIH HHS, United StatesN01-HB-73004, NHLBI NIH HHS, United StatesN01-HB-73005, NHLBI NIH 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NHLBI NIH HHS, United StatesN01-HC-45205, NHLBI NIH HHS, United StatesN01-HC-48047, NHLBI NIH HHS, United StatesN01-HC-48048, NHLBI NIH HHS, United StatesN01-HC-48049, NHLBI NIH HHS, United StatesN01-HC-48050, NHLBI NIH HHS, United StatesN01-HC-55015, NHLBI NIH HHS, United StatesN01-HC-55016, NHLBI NIH HHS, United StatesN01-HC-55017, NHLBI NIH HHS, United StatesN01-HC-55018, NHLBI NIH HHS, United StatesN01-HC-55019, NHLBI NIH HHS, United StatesN01-HC-55020, NHLBI NIH HHS, United StatesN01-HC-55021, NHLBI NIH HHS, United StatesN01-HC-65226, NHLBI NIH HHS, United StatesN01-HC-75150, NHLBI NIH HHS, United StatesN01-HC-85079, NHLBI NIH HHS, United StatesN01-HC-85080, NHLBI NIH HHS, United StatesN01-HC-85081, NHLBI NIH HHS, United StatesN01-HC-85082, NHLBI NIH HHS, United StatesN01-HC-85083, NHLBI NIH HHS, United StatesN01-HC-85084, NHLBI NIH HHS, United StatesN01-HC-85085, NHLBI NIH HHS, United StatesN01-HC-85086, NHLBI NIH HHS, United StatesN01-HC-95095, NHLBI NIH HHS, United 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year = "2011",

month = jun,

day = "1",

doi = "10.1093/hmg/ddr092",

language = "English",

volume = "20",

journal = "Human Molecular Genetics",

issn = "1460-2083",

publisher = "Oxford University Press",

number = "11",

}

Fox, ER, Young, JH, Li, Y, Dreisbach, AW, Keating, BJ, Musani, SK, Liu, K, Morrison, AC, Ganesh, S, Kutlar, A, Ramachandran, VS, Polak, JF, Fabsitz, RR, Dries, DL, Farlow, DN, Redline, S, Adeyemo, A, Hirschorn, JN, Sun, YV, Wyatt, SB, Penman, AD, Palmas, W, Rotter, JI, Townsend, RR, Doumatey, AP, Tayo, BO, Mosley, TH, Lyon, HN, Kang, SJ, Rotimi, CN, Cooper, RS, Franceschini, N, Curb, JD, Martin, LW, Eaton, CB, Kardia, SLR, Taylor, HA, Caulfield, MJ, Ehret, GB, Johnson, T, Chakravarti, A, Zhu, X, Levy, D, Munroe, PB, Rice, KM, Bochud, M, Johnson, AD, Chasman, DI, Smith, AV, Tobin, MD, Verwoert, GC, Hwang, S-J, Pihur, V, Vollenweider, P, O'Reilly, PF, Amin, N, Bragg-Gresham, JL, Teumer, A, Glazer, NL, Launer, L, Zhao, JH, Aulchenko, Y, Heath, S, Sõber, S, Parsa, A, Luan, J, Arora, P, Dehghan, A, Zhang, F, Lucas, G, Hicks, AA, Jackson, AU, Peden, JF, Tanaka, T, Wild, SH, Rudan, I, Igl, W, Milaneschi, Y, Parker, AN, Fava, C, Chambers, JC, Kumari, M, Go, MJ, van der Harst, P, Kao, WHL, Sjögren, M, Vinay, DG, Alexander, M, Tabara, Y, Shaw-Hawkins, S, Whincup, PH, Liu, Y, Shi, G, Kuusisto, J, Seielstad, M, Sim, X, Nguyen, K-DH, Lehtimäki, T, Matullo, G, Wu, Y, Gaunt, TR, Onland-Moret, NC, Cooper, MN, Platou, CGP, Org, E, Hardy, R, Dahgam, S, Palmen, J, Vitart, V, Braund, PS, Kuznetsova, T, Uiterwaal, CSPM, Campbell, H, Ludwig, B, Tomaszewski, M, Tzoulaki, I, Palmer, ND, CARDIoGRAM consortium, U, CKDGen consortium, U, KidneyGen consortium, U, EchoGen consortium, U, CHARGE-HF consortium, U, Aspelund, T, Garcia, M, Chang, Y-PC, O'Connell, JR, Steinle, NI, Grobbee, DE, Arking, DE, Hernandez, D, Najjar, S, McArdle, WL, Hadley, D, Brown, MJ, Connell, JM, Hingorani, AD, Day, INM, Lawlor, DA, Beilby, JP, Lawrence, RW, Clarke, R, Collins, R, Hopewell, JC, Ongen, H, Bis, JC, Kähönen, M, Viikari, J, Adair, LS, Lee, NR, Chen, M-H, Olden, M, Pattaro, C, Hoffman Bolton, JA, Köttgen, A, Bergmann, S, Mooser, V, Chaturvedi, N, Frayling, TM, Islam, M, Jafar, TH, Erdmann, J, Kulkarni, SR, Bornstein, SR, Grässler, J, Groop, L, Voight, BF, Kettunen, J, Howard, P, Taylor, A, Guarrera, S, Ricceri, F, Emilsson, V, Plump, A, Barroso, I, Khaw, K-T, Weder, AB, Hunt, SC, Bergman, RN, Collins, FS, Bonnycastle, LL, Scott, LJ, Stringham, HM, Peltonen, L, Perola, M, Vartiainen, E, Brand, S-M, Staessen, JA, Wang, TJ, Burton, PR, Soler Artigas, M, Dong, Y, Snieder, H, Wang, X, Zhu, H, Lohman, KK, Rudock, ME, Heckbert, SR, Smith, NL, Wiggins, KL, Shriner, D, Veldre, G, Viigimaa, M, Kinra, S, Prabhakaran, D, Tripathy, V, Langefeld, CD, Rosengren, A, Thelle, DS, Corsi, AM, Singleton, A, Forrester, T, Hilton, G, McKenzie, CA, Salako, T, Iwai, N, Kita, Y, Ogihara, T, Ohkubo, T, Okamura, T, Ueshima, H, Umemura, S, Eyheramendy, S, Meitinger, T, Wichmann, H-E, Cho, YS, Kim, H-L, Lee, J-Y, Scott, J, Sehmi, JS, Zhang, W, Hedblad, B, Nilsson, P, Smith, GD, Wong, A, Narisu, N, Stancáková, A, Raffel, LJ, Yao, J, Kathiresan, S, O'Donnell, C, Schwartz, SM, Ikram, MA, Longstreth, WT, Seshadri, S, Shrine, NRG, Wain, LV, Morken, MA, Swift, AJ, Laitinen, J, Prokopenko, I, Zitting, P, Cooper, JA, Humphries, SE, Danesh, J, Rasheed, A, oel, A, Hamsten, A, Watkins, H, Bakker, SJL, van Gilst, WH, Janipalli, CS, Mani, KR, Yajnik, CS, Hofman, A, Mattace-Raso, FUS, Oostra, BA, Demirkan, A, Isaacs, A, Rivadeneira, F, Lakatta, EG, Orru, M, Scuteri, A, Ala-Korpela, M, Kangas, AJ, Lyytikäinen, L-P, Soininen, P, Tukiainen, T, Würz, P, Ong, RT-H, Dörr, M, Kroemer, HK, Völker, U, Völzke, H, Galan, P, Hercberg, S, Lathrop, M, Zelenika, D, Deloukas, P, Mangino, M, Spector, TD, Zhai, G, Meschia, JF, Nalls, MA, Sharma, P, Terzic, J, Kumar, MJK, Denniff, M, Zukowska-Szczechowska, E, Wagenknecht, LE, Fowkes, FGR, Charchar, FJ, Schwarz, PEH, Hayward, C, Guo, X, Bots, ML, Brand, E, Samani, NJ, Polasek, O, Talmud, PJ, Nyberg, F, Kuh, D, Laan, M, Hveem, K, Palmer, LJ, van der Schouw, YT, Casas, JP, Mohlke, KL, Vineis, P, Raitakari, O, Wong, TY, Tai, ES, Laakso, M, Rao, DC, Harris, TB, Morris, RW, Dominiczak, AF, Kivimaki, M, Marmot, MG, Miki, T, Saleheen, D, Chandak, GR, Coresh, J, Navis, G, Salomaa, V, Han, B-G, Kooner, JS, Melander, O, Ridker, PM, Bandinelli, S, Gyllensten, UB, Wright, AF, Wilson, JF, Ferrucci, L, Farrall, M, Tuomilehto, J, Pramstaller, PP, Elosua, R, Soranzo, N, Sijbrands, EJG, Altshuler, D, Loos, RJF, Shuldiner, AR, Gieger, C, Meneton, P, Uitterlinden, AG, Wareham, NJ, Gudnason, V, Rettig, R, Uda, M, Strachan, DP, Witteman, JCM, Hartikainen, AL, Beckmann, JS, Boerwinkle, E, Boehnke, M, Larson, MG, Järvelin, M-R, Psaty, BM, Abecasis, GR, Elliott, P, van Duijn, CM & Newton-Cheh, C 2011, 'Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study.', Human Molecular Genetics, vol. 20, no. 11. https://doi.org/10.1093/hmg/ddr092

TY - JOUR

T1 - Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study.

AU - Fox, Ervin R

AU - Young, J Hunter

AU - Li, Yali

AU - Dreisbach, Albert W

AU - Keating, Brendan J

AU - Musani, Solomon K

AU - Liu, Kiang

AU - Morrison, Alanna C

AU - Ganesh, Santhi

AU - Kutlar, Abdullah

AU - Ramachandran, Vasan S

AU - Polak, Josef F

AU - Fabsitz, Richard R

AU - Dries, Daniel L

AU - Farlow, Deborah N

AU - Redline, Susan

AU - Adeyemo, Adebowale

AU - Hirschorn, Joel N

AU - Sun, Yan V

AU - Wyatt, Sharon B

AU - Penman, Alan D

AU - Palmas, Walter

AU - Rotter, Jerome I

AU - Townsend, Raymond R

AU - Doumatey, Ayo P

AU - Tayo, Bamidele O

AU - Mosley, Thomas H

AU - Lyon, Helen N

AU - Kang, Sun J

AU - Rotimi, Charles N

AU - Cooper, Richard S

AU - Franceschini, Nora

AU - Curb, J David

AU - Martin, Lisa W

AU - Eaton, Charles B

AU - Kardia, Sharon L R

AU - Taylor, Herman A

AU - Caulfield, Mark J

AU - Ehret, Georg B

AU - Johnson, Toby

AU - Chakravarti, Aravinda

AU - Zhu, Xiaofeng

AU - Levy, Daniel

A2 - Munroe, Patricia B

A2 - Rice, Kenneth M

A2 - Bochud, Murielle

A2 - Johnson, Andrew D

A2 - Chasman, Daniel I

A2 - Smith, Albert V

A2 - Tobin, Martin D

A2 - Verwoert, Germaine C

A2 - Hwang, Shih-Jen

A2 - Pihur, Vasyl

A2 - Vollenweider, Peter

A2 - O'Reilly, Paul F

A2 - Amin, Najaf

A2 - Bragg-Gresham, Jennifer L

A2 - Teumer, Alexander

A2 - Glazer, Nicole L

A2 - Launer, Lenore

A2 - Zhao, Jing Hua

A2 - Aulchenko, Yurii

A2 - Heath, Simon

A2 - Sõber, Siim

A2 - Parsa, Afshin

A2 - Luan, Jian'an

A2 - Arora, Pankaj

A2 - Dehghan, Abbas

A2 - Zhang, Feng

A2 - Lucas, Gavin

A2 - Hicks, Andrew A

A2 - Jackson, Anne U

A2 - Peden, John F

A2 - Tanaka, Toshiko

A2 - Wild, Sarah H

A2 - Rudan, Igor

A2 - Igl, Wilmar

A2 - Milaneschi, Yuri

A2 - Parker, Alex N

A2 - Fava, Cristiano

A2 - Chambers, John C

A2 - Kumari, Meena

A2 - Go, Min Jin

A2 - van der Harst, Pim

A2 - Kao, Wen Hong Linda

A2 - Sjögren, Marketa

A2 - Vinay, D G

A2 - Alexander, Myriam

A2 - Tabara, Yasuharu

A2 - Shaw-Hawkins, Sue

A2 - Whincup, Peter H

A2 - Liu, Yongmei

A2 - Shi, Gang

A2 - Kuusisto, Johanna

A2 - Seielstad, Mark

A2 - Sim, Xueling

A2 - Nguyen, Khanh-Dung Hoang

A2 - Lehtimäki, Terho

A2 - Matullo, Giuseppe

A2 - Wu, Ying

A2 - Gaunt, Tom R

A2 - Onland-Moret, N Charlotte

A2 - Cooper, Matthew N

A2 - Platou, Carl G P

A2 - Org, Elin

A2 - Hardy, Rebecca

A2 - Dahgam, Santosh

A2 - Palmen, Jutta

A2 - Vitart, Veronique

A2 - Braund, Peter S

A2 - Kuznetsova, Tatiana

A2 - Uiterwaal, Cuno S P M

A2 - Campbell, Harry

A2 - Ludwig, Barbara

A2 - Tomaszewski, Maciej

A2 - Tzoulaki, Ioanna

A2 - Palmer, Nicholette D

A2 - CARDIoGRAM consortium, [Unknown]

A2 - CKDGen consortium, [Unknown]

A2 - KidneyGen consortium, [Unknown]

A2 - EchoGen consortium, [Unknown]

A2 - CHARGE-HF consortium, [Unknown]

A2 - Aspelund, Thor

A2 - Garcia, Melissa

A2 - Chang, Yen-Pei C

A2 - O'Connell, Jeffrey R

A2 - Steinle, Nanette I

A2 - Grobbee, Diederick E

A2 - Arking, Dan E

A2 - Hernandez, Dena

A2 - Najjar, Samer

A2 - McArdle, Wendy L

A2 - Hadley, David

A2 - Brown, Morris J

A2 - Connell, John M

A2 - Hingorani, Aroon D

A2 - Day, Ian N M

A2 - Lawlor, Debbie A

A2 - Beilby, John P

A2 - Lawrence, Robert W

A2 - Clarke, Robert

A2 - Collins, Rory

A2 - Hopewell, Jemma C

A2 - Ongen, Halit

A2 - Bis, Joshua C

A2 - Kähönen, Mika

A2 - Viikari, Jorma

A2 - Adair, Linda S

A2 - Lee, Nanette R

A2 - Chen, Ming-Huei

A2 - Olden, Matthias

A2 - Pattaro, Cristian

A2 - Hoffman Bolton, Judith A

A2 - Köttgen, Anna

A2 - Bergmann, Sven

A2 - Mooser, Vincent

A2 - Chaturvedi, Nish

A2 - Frayling, Timothy M

A2 - Islam, Muhammad

A2 - Jafar, Tazeen H

A2 - Erdmann, Jeanette

A2 - Kulkarni, Smita R

A2 - Bornstein, Stefan R

A2 - Grässler, Jürgen

A2 - Groop, Leif

A2 - Voight, Benjamin F

A2 - Kettunen, Johannes

A2 - Howard, Philip

A2 - Taylor, Andrew

A2 - Guarrera, Simonetta

A2 - Ricceri, Fulvio

A2 - Emilsson, Valur

A2 - Plump, Andrew

A2 - Barroso, Inês

A2 - Khaw, Kay-Tee

A2 - Weder, Alan B

A2 - Hunt, Steven C

A2 - Bergman, Richard N

A2 - Collins, Francis S

A2 - Bonnycastle, Lori L

A2 - Scott, Laura J

A2 - Stringham, Heather M

A2 - Peltonen, Leena

A2 - Perola, Markus

A2 - Vartiainen, Erkki

A2 - Brand, Stefan-Martin

A2 - Staessen, Jan A

A2 - Wang, Thomas J

A2 - Burton, Paul R

A2 - Soler Artigas, Maria

A2 - Dong, Yanbin

A2 - Snieder, Harold

A2 - Wang, Xiaoling

A2 - Zhu, Haidong

A2 - Lohman, Kurt K

A2 - Rudock, Megan E

A2 - Heckbert, Susan R

A2 - Smith, Nicholas L

A2 - Wiggins, Kerri L

A2 - Shriner, Daniel

A2 - Veldre, Gudrun

A2 - Viigimaa, Margus

A2 - Kinra, Sanjay

A2 - Prabhakaran, Dorairajan

A2 - Tripathy, Vikal

A2 - Langefeld, Carl D

A2 - Rosengren, Annika

A2 - Thelle, Dag S

A2 - Corsi, Anna Maria

A2 - Singleton, Andrew

A2 - Forrester, Terrence

A2 - Hilton, Gina

A2 - McKenzie, Colin A

A2 - Salako, Tunde

A2 - Iwai, Naoharu

A2 - Kita, Yoshikuni

A2 - Ogihara, Toshio

A2 - Ohkubo, Takayoshi

A2 - Okamura, Tomonori

A2 - Ueshima, Hirotsugu

A2 - Umemura, Satoshi

A2 - Eyheramendy, Susana

A2 - Meitinger, Thomas

A2 - Wichmann, H-Erich

A2 - Cho, Yoon Shin

A2 - Kim, Hyung-Lae

A2 - Lee, Jong-Young

A2 - Scott, James

A2 - Sehmi, Joban S

A2 - Zhang, Weihua

A2 - Hedblad, Bo

A2 - Nilsson, Peter

A2 - Smith, George Davey

A2 - Wong, Andrew

A2 - Narisu, Narisu

A2 - Stancáková, Alena

A2 - Raffel, Leslie J

A2 - Yao, Jie

A2 - Kathiresan, Sekar

A2 - O'Donnell, Chris

A2 - Schwartz, Steven M

A2 - Ikram, M Arfan

A2 - Longstreth, Will T

A2 - Seshadri, Sudha

A2 - Shrine, Nick R G

A2 - Wain, Louise V

A2 - Morken, Mario A

A2 - Swift, Amy J

A2 - Laitinen, Jaana

A2 - Prokopenko, Inga

A2 - Zitting, Paavo

A2 - Cooper, Jackie A

A2 - Humphries, Steve E

A2 - Danesh, John

A2 - Rasheed, Asif

A2 - oel, Anuj

A2 - Hamsten, Anders

A2 - Watkins, Hugh

A2 - Bakker, Stephan J L

A2 - van Gilst, Wiek H

A2 - Janipalli, Charles S

A2 - Mani, K Radha

A2 - Yajnik, Chittaranjan S

A2 - Hofman, Albert

A2 - Mattace-Raso, Francesco U S

A2 - Oostra, Ben A

A2 - Demirkan, Ayse

A2 - Isaacs, Aaron

A2 - Rivadeneira, Fernando

A2 - Lakatta, Edward G

A2 - Orru, Marco

A2 - Scuteri, Angelo

A2 - Ala-Korpela, Mika

A2 - Kangas, Antti J

A2 - Lyytikäinen, Leo-Pekka

A2 - Soininen, Pasi

A2 - Tukiainen, Taru

A2 - Würz, Peter

A2 - Ong, Rick Twee-Hee

A2 - Dörr, Marcus

A2 - Kroemer, Heyo K

A2 - Völker, Uwe

A2 - Völzke, Henry

A2 - Galan, Pilar

A2 - Hercberg, Serge

A2 - Lathrop, Mark

A2 - Zelenika, Diana

A2 - Deloukas, Panos

A2 - Mangino, Massimo

A2 - Spector, Tim D

A2 - Zhai, Guangju

A2 - Meschia, James F

A2 - Nalls, Michael A

A2 - Sharma, Pankaj

A2 - Terzic, Janos

A2 - Kumar, M J Kranthi

A2 - Denniff, Matthew

A2 - Zukowska-Szczechowska, Ewa

A2 - Wagenknecht, Lynne E

A2 - Fowkes, F Gerald R

A2 - Charchar, Fadi J

A2 - Schwarz, Peter E H

A2 - Hayward, Caroline

A2 - Guo, Xiuqing

A2 - Bots, Michiel L

A2 - Brand, Eva

A2 - Samani, Nilesh J

A2 - Polasek, Ozren

A2 - Talmud, Philippa J

A2 - Nyberg, Fredrik

A2 - Kuh, Diana

A2 - Laan, Maris

A2 - Hveem, Kristian

A2 - Palmer, Lyle J

A2 - van der Schouw, Yvonne T

A2 - Casas, Juan P

A2 - Mohlke, Karen L

A2 - Vineis, Paolo

A2 - Raitakari, Olli

A2 - Wong, Tien Y

A2 - Tai, E Shyong

A2 - Laakso, Markku

A2 - Rao, Dabeeru C

A2 - Harris, Tamara B

A2 - Morris, Richard W

A2 - Dominiczak, Anna F

A2 - Kivimaki, Mika

A2 - Marmot, Michael G

A2 - Miki, Tetsuro

A2 - Saleheen, Danish

A2 - Chandak, Giriraj R

A2 - Coresh, Josef

A2 - Navis, Gerjan

A2 - Salomaa, Veikko

A2 - Han, Bok-Ghee

A2 - Kooner, Jaspal S

A2 - Melander, Olle

A2 - Ridker, Paul M

A2 - Bandinelli, Stefania

A2 - Gyllensten, Ulf B

A2 - Wright, Alan F

A2 - Wilson, James F

A2 - Ferrucci, Luigi

A2 - Farrall, Martin

A2 - Tuomilehto, Jaakko

A2 - Pramstaller, Peter P

A2 - Elosua, Roberto

A2 - Soranzo, Nicole

A2 - Sijbrands, Eric J G

A2 - Altshuler, David

A2 - Loos, Ruth J F

A2 - Shuldiner, Alan R

A2 - Gieger, Christian

A2 - Meneton, Pierre

A2 - Uitterlinden, Andre G

A2 - Wareham, Nicholas J

A2 - Gudnason, Vilmundur

A2 - Rettig, Rainer

A2 - Uda, Manuela

A2 - Strachan, David P

A2 - Witteman, Jacqueline C M

A2 - Hartikainen, Anna Liisa

A2 - Beckmann, Jacques S

A2 - Boerwinkle, Eric

A2 - Boehnke, Michael

A2 - Larson, Martin G

A2 - Järvelin, Marjo-Riitt

A2 - Psaty, Bruce M

A2 - Abecasis, Gonçalo R

A2 - Elliott, Paul

A2 - van Duijn, Cornelia M

A2 - Newton-Cheh, Christopher

N1 - 090532, Wellcome Trust, United KingdomG0100222, Medical Research Council, United KingdomG0400874, Medical Research Council, United KingdomG0401527, Medical Research Council, United KingdomG0600705, Medical Research Council, United KingdomG0701863, Medical Research Council, United KingdomG0801056, Medical Research Council, United KingdomG0902037, Medical Research Council, United KingdomG0902313, Medical Research Council, United KingdomG1000143, Medical Research Council, United KingdomG19/35, Medical Research Council, United KingdomG8802774, Medical Research Council, United KingdomG9521010, Medical Research Council, United KingdomHG003054, NHGRI NIH HHS, United StatesHL074166, NHLBI NIH HHS, United StatesHL086694, NHLBI NIH HHS, United StatesHL086718, NHLBI NIH HHS, United StatesHL087660, NHLBI NIH HHS, United StatesHL100245, NHLBI NIH HHS, United StatesMC_QA137934, Medical Research Council, United KingdomMC_U106179471, Medical Research Council, United KingdomMC_U106188470, Medical Research Council, United KingdomMC_U123092720, Medical Research Council, United KingdomMC_U123092721, Medical Research Council, United KingdomMC_U127561128, Medical Research Council, United KingdomMC_U137686857, Medical Research Council, United KingdomMD002249, NIMHD NIH HHS, United StatesN01 HC-15103, NHLBI NIH HHS, United StatesN01 HC-55222, NHLBI NIH HHS, United StatesN01-HB-72982, NHLBI NIH HHS, United StatesN01-HB-72991, NHLBI NIH HHS, United StatesN01-HB-72992, NHLBI NIH HHS, United StatesN01-HB-72993, NHLBI NIH HHS, United StatesN01-HB-72994, NHLBI NIH HHS, United StatesN01-HB-72995, NHLBI NIH HHS, United StatesN01-HB-72996, NHLBI NIH HHS, United StatesN01-HB-72997, NHLBI NIH HHS, United StatesN01-HB-72998, NHLBI NIH HHS, United StatesN01-HB-73000, NHLBI NIH HHS, United StatesN01-HB-73001, NHLBI NIH HHS, United StatesN01-HB-73002, NHLBI NIH HHS, United StatesN01-HB-73003, NHLBI NIH HHS, United StatesN01-HB-73004, NHLBI NIH HHS, United StatesN01-HB-73005, NHLBI NIH HHS, United 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StatesN01WH42131, WHI NIH HHS, United StatesN01WH42132, WHI NIH HHS, United StatesN01WH444221, WHI NIH HHS, United StatesP30 DK072488, NIDDK NIH HHS, United StatesR01 HL46380-01-16, NHLBI NIH HHS, United StatesR24 HD050924, NICHD NIH HHS, United StatesRG/07/008/23674, British Heart Foundation, United KingdomRG/08/008/25291, British Heart Foundation, United KingdomRG/08/014/24067, British Heart Foundation, United KingdomU01 HL053916, NHLBI NIH HHS, United StatesU01 HL053934, NHLBI NIH HHS, United StatesU01 HL053937, NHLBI NIH HHS, United StatesU01 HL053938, NHLBI NIH HHS, United StatesU01 HL053941, NHLBI NIH HHS, United StatesU01 HL063429, NHLBI NIH HHS, United StatesU01 HL063463, NHLBI NIH HHS, United StatesU01 HL064360, NHLBI NIH HHS, United StatesU01 HL077813, NHLBI NIH HHS, United StatesU01-HL080295, NHLBI NIH HHS, United States, Intramural NIH HHS, United States

PY - 2011/6/1

Y1 - 2011/6/1

N2 - The prevalence of hypertension in African Americans (AAs) is higher than in other US groups; yet, few have performed genome-wide association studies (GWASs) in AA. Among people of European descent, GWASs have identified genetic variants at 13 loci that are associated with blood pressure. It is unknown if these variants confer susceptibility in people of African ancestry. Here, we examined genome-wide and candidate gene associations with systolic blood pressure (SBP) and diastolic blood pressure (DBP) using the Candidate Gene Association Resource (CARe) consortium consisting of 8591 AAs. Genotypes included genome-wide single-nucleotide polymorphism (SNP) data utilizing the Affymetrix 6.0 array with imputation to 2.5 million HapMap SNPs and candidate gene SNP data utilizing a 50K cardiovascular gene-centric array (ITMAT-Broad-CARe [IBC] array). For Affymetrix data, the strongest signal for DBP was rs10474346 (P= 3.6 × 10(-8)) located near GPR98 and ARRDC3. For SBP, the strongest signal was rs2258119 in C21orf91 (P= 4.7 × 10(-8)). The top IBC association for SBP was rs2012318 (P= 6.4 × 10(-6)) near SLC25A42 and for DBP was rs2523586 (P= 1.3 × 10(-6)) near HLA-B. None of the top variants replicated in additional AA (n = 11 882) or European-American (n = 69 899) cohorts. We replicated previously reported European-American blood pressure SNPs in our AA samples (SH2B3, P= 0.009; TBX3-TBX5, P= 0.03; and CSK-ULK3, P= 0.0004). These genetic loci represent the best evidence of genetic influences on SBP and DBP in AAs to date. More broadly, this work supports that notion that blood pressure among AAs is a trait with genetic underpinnings but also with significant complexity.

AB - The prevalence of hypertension in African Americans (AAs) is higher than in other US groups; yet, few have performed genome-wide association studies (GWASs) in AA. Among people of European descent, GWASs have identified genetic variants at 13 loci that are associated with blood pressure. It is unknown if these variants confer susceptibility in people of African ancestry. Here, we examined genome-wide and candidate gene associations with systolic blood pressure (SBP) and diastolic blood pressure (DBP) using the Candidate Gene Association Resource (CARe) consortium consisting of 8591 AAs. Genotypes included genome-wide single-nucleotide polymorphism (SNP) data utilizing the Affymetrix 6.0 array with imputation to 2.5 million HapMap SNPs and candidate gene SNP data utilizing a 50K cardiovascular gene-centric array (ITMAT-Broad-CARe [IBC] array). For Affymetrix data, the strongest signal for DBP was rs10474346 (P= 3.6 × 10(-8)) located near GPR98 and ARRDC3. For SBP, the strongest signal was rs2258119 in C21orf91 (P= 4.7 × 10(-8)). The top IBC association for SBP was rs2012318 (P= 6.4 × 10(-6)) near SLC25A42 and for DBP was rs2523586 (P= 1.3 × 10(-6)) near HLA-B. None of the top variants replicated in additional AA (n = 11 882) or European-American (n = 69 899) cohorts. We replicated previously reported European-American blood pressure SNPs in our AA samples (SH2B3, P= 0.009; TBX3-TBX5, P= 0.03; and CSK-ULK3, P= 0.0004). These genetic loci represent the best evidence of genetic influences on SBP and DBP in AAs to date. More broadly, this work supports that notion that blood pressure among AAs is a trait with genetic underpinnings but also with significant complexity.

UR - https://www.scopus.com/pages/publications/79956051525

U2 - 10.1093/hmg/ddr092

DO - 10.1093/hmg/ddr092

M3 - Article

C2 - 21378095

SN - 1460-2083

VL - 20

JO - Human Molecular Genetics

JF - Human Molecular Genetics

IS - 11

ER -

Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study.

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