Association of PTGDR gene polymorphisms with asthma in two Caucasian populations

G. Zhu, J. Vestbo, W. Lenney, M. Silverman, M. Whyte, P. Helms, W. H. Anderson, S. G. Pillai

    Research output: Contribution to journalArticlepeer-review


    The prostanoid DP receptor (PTGDR) is shown to be involved in the asthma patho-physiology and the results from the published genetic association studies are inconsistent. Four single nucleotide polymorphisms (SNPs) in PTGDR were genotyped in 342 and 294 families from UK and Denmark respectively. Asthma and asthma-related phenotypes were analyzed using family-based association analyses. In the UK families, a promoter polymorphism (-731A/G) showed significant associations with asthma (P=0.0022), atopic asthma (P=0.0044), bronchial hyperreactivity or BHR (P=0.00120) and strict asthma (P=0.0008). The P-values for asthma, BHR and strict asthma were significant even after the most stringent correction for the number of markers and the number of phenotypes analyzed (
    Original languageEnglish
    Pages (from-to)398-403
    Number of pages5
    JournalGenes and Immunity
    Issue number5
    Publication statusPublished - Jul 2007


    • Adolescent
    • Adult
    • genetics: Asthma
    • Denmark
    • genetics: European Continental Ancestry Group
    • Female
    • Genetic Predisposition to Disease
    • Genotype
    • Great Britain
    • Haplotypes
    • Humans
    • Male
    • Middle Aged
    • Phenotype
    • Polymorphism, Single Nucleotide
    • genetics: Receptors, Immunologic
    • genetics: Receptors, Prostaglandin


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