Association of PTGDR gene polymorphisms with asthma in two Caucasian populations

G. Zhu; J. Vestbo; W. Lenney; M. Silverman; M. Whyte; P. Helms; W. H. Anderson; S. G. Pillai

doi:10.1038/sj.gene.6364399

Association of PTGDR gene polymorphisms with asthma in two Caucasian populations

G. Zhu, J. Vestbo, W. Lenney, M. Silverman, M. Whyte, P. Helms, W. H. Anderson, S. G. Pillai

Research output: Contribution to journal › Article › peer-review

Abstract

The prostanoid DP receptor (PTGDR) is shown to be involved in the asthma patho-physiology and the results from the published genetic association studies are inconsistent. Four single nucleotide polymorphisms (SNPs) in PTGDR were genotyped in 342 and 294 families from UK and Denmark respectively. Asthma and asthma-related phenotypes were analyzed using family-based association analyses. In the UK families, a promoter polymorphism (-731A/G) showed significant associations with asthma (P=0.0022), atopic asthma (P=0.0044), bronchial hyperreactivity or BHR (P=0.00120) and strict asthma (P=0.0008). The P-values for asthma, BHR and strict asthma were significant even after the most stringent correction for the number of markers and the number of phenotypes analyzed (

Original language	English
Pages (from-to)	398-403
Number of pages	5
Journal	Genes and Immunity
Volume	8
Issue number	5
DOIs	https://doi.org/10.1038/sj.gene.6364399
Publication status	Published - Jul 2007

Keywords

Adolescent
Adult
genetics: Asthma
Denmark
genetics: European Continental Ancestry Group
Female
Genetic Predisposition to Disease
Genotype
Great Britain
Haplotypes
Humans
Male
Middle Aged
Phenotype
Polymorphism, Single Nucleotide
genetics: Receptors, Immunologic
genetics: Receptors, Prostaglandin

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/sj.gene.6364399

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title = "Association of PTGDR gene polymorphisms with asthma in two Caucasian populations",

abstract = "The prostanoid DP receptor (PTGDR) is shown to be involved in the asthma patho-physiology and the results from the published genetic association studies are inconsistent. Four single nucleotide polymorphisms (SNPs) in PTGDR were genotyped in 342 and 294 families from UK and Denmark respectively. Asthma and asthma-related phenotypes were analyzed using family-based association analyses. In the UK families, a promoter polymorphism (-731A/G) showed significant associations with asthma (P=0.0022), atopic asthma (P=0.0044), bronchial hyperreactivity or BHR (P=0.00120) and strict asthma (P=0.0008). The P-values for asthma, BHR and strict asthma were significant even after the most stringent correction for the number of markers and the number of phenotypes analyzed (",

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author = "G. Zhu and J. Vestbo and W. Lenney and M. Silverman and M. Whyte and P. Helms and Anderson, {W. H.} and Pillai, {S. G.}",

year = "2007",

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doi = "10.1038/sj.gene.6364399",

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T1 - Association of PTGDR gene polymorphisms with asthma in two Caucasian populations

AU - Zhu, G.

AU - Vestbo, J.

AU - Lenney, W.

AU - Silverman, M.

AU - Whyte, M.

AU - Helms, P.

AU - Anderson, W. H.

AU - Pillai, S. G.

PY - 2007/7

Y1 - 2007/7

N2 - The prostanoid DP receptor (PTGDR) is shown to be involved in the asthma patho-physiology and the results from the published genetic association studies are inconsistent. Four single nucleotide polymorphisms (SNPs) in PTGDR were genotyped in 342 and 294 families from UK and Denmark respectively. Asthma and asthma-related phenotypes were analyzed using family-based association analyses. In the UK families, a promoter polymorphism (-731A/G) showed significant associations with asthma (P=0.0022), atopic asthma (P=0.0044), bronchial hyperreactivity or BHR (P=0.00120) and strict asthma (P=0.0008). The P-values for asthma, BHR and strict asthma were significant even after the most stringent correction for the number of markers and the number of phenotypes analyzed (

AB - The prostanoid DP receptor (PTGDR) is shown to be involved in the asthma patho-physiology and the results from the published genetic association studies are inconsistent. Four single nucleotide polymorphisms (SNPs) in PTGDR were genotyped in 342 and 294 families from UK and Denmark respectively. Asthma and asthma-related phenotypes were analyzed using family-based association analyses. In the UK families, a promoter polymorphism (-731A/G) showed significant associations with asthma (P=0.0022), atopic asthma (P=0.0044), bronchial hyperreactivity or BHR (P=0.00120) and strict asthma (P=0.0008). The P-values for asthma, BHR and strict asthma were significant even after the most stringent correction for the number of markers and the number of phenotypes analyzed (

KW - Adolescent

KW - Adult

KW - genetics: Asthma

KW - Denmark

KW - genetics: European Continental Ancestry Group

KW - Female

KW - Genetic Predisposition to Disease

KW - Genotype

KW - Great Britain

KW - Haplotypes

KW - Humans

KW - Male

KW - Middle Aged

KW - Phenotype

KW - Polymorphism, Single Nucleotide

KW - genetics: Receptors, Immunologic

KW - genetics: Receptors, Prostaglandin

U2 - 10.1038/sj.gene.6364399

DO - 10.1038/sj.gene.6364399

M3 - Article

SN - 1466-4879

VL - 8

SP - 398

EP - 403

JO - Genes and Immunity

JF - Genes and Immunity

IS - 5

ER -

Association of PTGDR gene polymorphisms with asthma in two Caucasian populations

Abstract

Keywords

UN SDGs

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