Abstract
To determine the effect of the major histocompatibility complex on the development of symptoms during acute human parvovirus B19 infection, we compared human leukocyte antigen (HLA) class I and II alleles in 36 patients with symptomatic acute B19 infection with those in >900 control subjects from northwestern England. The frequency of each of HLA-DRB1*01 (P = .016), DRB1*04 (P = .007), and DRB1*07 (P <.0001) alleles was significantly higher in parvovirus B19 patients than in control subjects. In the parvovirus group, 63.9% carried the rheumatoid arthritis-associated shared epitope sequence, compared with 45% of control subjects (odds ratio [OR], 2.2; 95% confidence interval [CI], 0.97-4.8; P = .04), and carriage was associated with fatigue during the acute phase (OR, 4.2; 95% CI, 0.8-23.9; P = .047). All symptomatic parvovirus-associated HLA-DRB1 molecules carry a neutrally charged glutamine at position 10 and a positively charged lysine at position 12 of the first hypervariable region. HLA-B49 was associated with parvovirus infection independently of HLA-DRB1*01, DRB1*04, and DRB1*07.
Original language | English |
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Pages (from-to) | 447-452 |
Number of pages | 5 |
Journal | Journal of Infectious Diseases |
Volume | 186 |
Issue number | 4 |
DOIs | |
Publication status | Published - 15 Aug 2002 |
Keywords
- Acute Disease
- Adolescent
- Adult
- Aged
- Alleles
- Amino Acid Sequence
- Child
- England
- Female
- Gene Frequency
- Genes,MHC Class I
- Genes,MHC Class II
- genetics
- HLA-B Antigens
- HLA-DR Antigens
- Human
- immunology
- Lung
- Major Histocompatibility Complex
- Male
- Middle Age
- Molecular Sequence Data
- Odds Ratio
- Parvoviridae Infections
- Parvovirus B19,Human
- physiopathology
- Support,Non-U.S.Gov't