Association of the CCR5 gene with juvenile idiopathic arthritis

A. Hinks, P. Martin, E. Flynn, S. Eyre, J. Packham, A. Barton, J. Worthington, W. Thomson

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The CC chemokine receptor 5 (CCR5) has been shown to be important in the recruitment of T-helper cells to the synovium, where they accumulate, drive the inflammatory process and the consequent synovitis and joint destruction. A 32 base-pair insertion/deletion variant (CCR5Δ32) within the gene leads to a frame shift and a nonfunctional receptor. CCR5Δ32 has been investigated for its association with juvenile idiopathic arthritis (JIA), with conflicting results. The aim of this study was to investigate whether CCR5Δ32 is associated with JIA in an UK population. CCR5Δ32 was genotyped in JIA cases (n1054) and healthy controls (n3129) and genotype and allele frequencies were compared. A meta-analysis of our study combined with previously published studies was performed. CCR5Δ32 was significantly associated with protection from developing JIA, in this UK data set (P trend 0.006, odds ratio (OR) 0.79 95% confidence interval (95% CI): 0.66-0.94). The meta-analysis of all published case-control association studies confirmed the protective association with JIA (P
    Original languageEnglish
    Pages (from-to)584-589
    Number of pages5
    JournalGenes and Immunity
    Volume11
    Issue number7
    DOIs
    Publication statusPublished - Oct 2010

    Keywords

    • CCR5
    • chemokine
    • juvenile idiopathic arthritis

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