Association of trisomy 8 and squamous differentiation in an endometrial adenocarcinoma

J A Fletcher; J C Aster; C C Morton

Association of trisomy 8 and squamous differentiation in an endometrial adenocarcinoma

J A Fletcher, J C Aster, C C Morton

Division of Evolution, Infection and Genomics

Dana-Farber Cancer Institute

Research output: Contribution to journal › Article › peer-review

Abstract

Cytogenetic analysis was performed on a case of endometrial adenocarcinoma in which 10% to 15% of the tumor showed squamous differentiation. Of 26 cells examined, all had trisomy 1q and monosomy 16; four cells (15%) also showed trisomy 8. Trisomy 8 is an unusual finding in endometrial carcinoma, having been reported in only one other case, which was an adenosquamous carcinoma. Our findings suggest that trisomy 8 may be a marker of squamous differentiation in endometrial carcinoma.

Original language	English
Pages (from-to)	185-9
Number of pages	5
Journal	Cancer Genetics and Cytogenetics
Volume	39
Issue number	2
Publication status	Published - Jun 1989

Keywords

Adenocarcinoma
Aged
Carcinoma, Squamous Cell
Chromosomes, Human, Pair 8
Female
Humans
Karyotyping
Trisomy
Uterine Neoplasms
Case Reports
Journal Article

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Association of trisomy 8 and squamous differentiation in an endometrial adenocarcinoma",

abstract = "Cytogenetic analysis was performed on a case of endometrial adenocarcinoma in which 10% to 15% of the tumor showed squamous differentiation. Of 26 cells examined, all had trisomy 1q and monosomy 16; four cells (15%) also showed trisomy 8. Trisomy 8 is an unusual finding in endometrial carcinoma, having been reported in only one other case, which was an adenosquamous carcinoma. Our findings suggest that trisomy 8 may be a marker of squamous differentiation in endometrial carcinoma.",

keywords = "Adenocarcinoma, Aged, Carcinoma, Squamous Cell, Chromosomes, Human, Pair 8, Female, Humans, Karyotyping, Trisomy, Uterine Neoplasms, Case Reports, Journal Article",

author = "Fletcher, {J A} and Aster, {J C} and Morton, {C C}",

year = "1989",

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language = "English",

volume = "39",

pages = "185--9",

journal = "Cancer Genetics and Cytogenetics",

issn = "0165-4608",

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TY - JOUR

T1 - Association of trisomy 8 and squamous differentiation in an endometrial adenocarcinoma

AU - Fletcher, J A

AU - Aster, J C

AU - Morton, C C

PY - 1989/6

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N2 - Cytogenetic analysis was performed on a case of endometrial adenocarcinoma in which 10% to 15% of the tumor showed squamous differentiation. Of 26 cells examined, all had trisomy 1q and monosomy 16; four cells (15%) also showed trisomy 8. Trisomy 8 is an unusual finding in endometrial carcinoma, having been reported in only one other case, which was an adenosquamous carcinoma. Our findings suggest that trisomy 8 may be a marker of squamous differentiation in endometrial carcinoma.

AB - Cytogenetic analysis was performed on a case of endometrial adenocarcinoma in which 10% to 15% of the tumor showed squamous differentiation. Of 26 cells examined, all had trisomy 1q and monosomy 16; four cells (15%) also showed trisomy 8. Trisomy 8 is an unusual finding in endometrial carcinoma, having been reported in only one other case, which was an adenosquamous carcinoma. Our findings suggest that trisomy 8 may be a marker of squamous differentiation in endometrial carcinoma.

KW - Adenocarcinoma

KW - Aged

KW - Carcinoma, Squamous Cell

KW - Chromosomes, Human, Pair 8

KW - Female

KW - Humans

KW - Karyotyping

KW - Trisomy

KW - Uterine Neoplasms

KW - Case Reports

KW - Journal Article

M3 - Article

C2 - 2752371

SN - 0165-4608

VL - 39

SP - 185

EP - 189

JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

IS - 2

ER -

Association of trisomy 8 and squamous differentiation in an endometrial adenocarcinoma

Abstract

Keywords

UN SDGs

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