Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

Paul R. Burton; David G. Clayton; Lon R. Cardon; Nick Craddock; Audrey Duncanson; Dominic P. Kwiatkowski; Mark I. McCarthy; Willem H. Ouwehand; Nilesh J. Samani; John A. Todd; Peter Donnelly; Jeffrey C. Barrett; Dan Davison; Doug Easton; David M. Evans; Hin Tak Leung; Jonathan L. Marchini; Andrew P. Morris; Chris C A Spencer; Martin D. Tobin; Antony P. Attwood; James P. Boorman; Barbara Cant; Ursula Everson; Judith M. Hussey; Jennifer D. Jolley; Alexandra S. Knight; Kerstin Koch; Elizabeth Meech; Sarah Nutland; Christopher V. Prowse; Helen E. Stevens; Niall C. Taylor; Graham R. Walters; Neil M. Walker; Nicholas A. Watkins; Thilo Winzer; Richard W. Jones; Wendy L. McArdle; Susan M. Ring; David P. Strachan; Marcus Pembrey; Gerome Breen; David St Clair; Sian Caesar; Katharine Gordon-Smith; Lisa Jones; Christine Fraser; Elaine K. Green; Detelina Grozeva; Marian L. Hamshere; Peter A. Holmans; Ian R. Jones; George Kirov; Valentina Moskivina; Ivan Nikolov; Michael C. O'Donovan; Michael J. Owen; David A. Collier; Amanda Elkin; Anne Farmer; Richard Williamson; Peter McGuffin; Allan H. Young; I. Nicol Ferrier; Stephen G. Ball; Anthony J. Balmforth; Jennifer H. Barrett; Timothy D. Bishop; Mark M. Iles; Azhar Maqbool; Nadira Yuldasheva; Alistair S. Hall; Peter S. Braund; Richard J. Dixon; Massimo Mangino; Suzanne Stevens; John R. Thompson; Francesca Bredin; Mark Tremelling; Miles Parkes; Hazel Drummond; Charles W. Lees; Elaine R. Nimmo; Jack Satsangi; Sheila A. Fisher; Alastair Forbes; Cathryn M. Lewis; Clive M. Onnie; Natalie J. Prescott; Jeremy Sanderson; Christopher G. Matthew; Jamie Barbour; M. Khalid Mohiuddin; Catherine E. Todhunter; John C. Mansfield; Tariq Ahmad; Fraser R. Cummings; Derek P. Jewell; John Webster; Morris J. Brown; Mark G. Lathrop; John Connell; Anna Dominiczak; Carolina A Braga Marcano; Beverley Burke; Richard Dobson; Johannie Gungadoo; Kate L. Lee; Patricia B. Munroe; Stephen J. Newhouse; Abiodun Onipinla; Chris Wallace; Mingzhan Xue; Mark Caulfield; Martin Farrall; Anne Barton; Ian N. Bruce; Hannah Donovan; Steve Eyre; Paul D. Gilbert; Samantha L. Hilder; Anne M. Hinks; Sally L. John; Catherine Potter; Alan J. Silman; Deborah P M Symmons; Wendy Thomson; Jane Worthington; David B. Dunger; Barry Widmer; Timothy M. Frayling; Rachel M. Freathy; Hana Lango; John R B Perry; Beverley M. Shields; Michael N. Weedon; Andrew T. Hattersley; Graham A. Hitman; Mark Walker; Kate S. Elliott; Christopher J. Groves; Cecilia M. Lindgren; Nigel W. Rayner; Nicolas J. Timpson; Eleftheria Zeggini; Melanie Newport; Giorgio Sirugo; Emily Lyons; Fredrik Vannberg; Adrian V S Hill; Linda A. Bradbury; Claire Farrar; Jennifer J. Pointon; Paul Wordsworth; Matthew A. Brown; Jayne A. Franklyn; Joanne M. Heward; Matthew J. Simmonds; Sheila Seal; Michael R. Stratton; Nazneen Rahman; Maria Ban; An Goris; Stephen J. Sawcer; Alastair Compston; David Conway; Muminatou Jallow; Kirk A. Rockett; Suzannah J. Bumpstead; Amy Chaney; Kate Downes; Mohammed J R Ghori; Rhian Gwilliam; Sarah E. Hunt; Michael Inouye; Emma King; Simon Potter; Rathi Ravindrarajah; Pamela Whittaker; Claire Widden; David Withers; Niall J. Cardin; Teresa Ferreira; Joanne Pereira-Gale; Ingeleif B. Hallgrimsdóttir; Bryan N. Howie; Zhan Su; Yik Ying Teo; Damjan Vukcevic; David Bentley; Sarah L. Mitchell; Paul R. Newby; Oliver J. Brand; Jackie Carr-Smith; Simon H S Pearce; Stephen C L Gough; R. McGinnis; A. Keniry; P. Deloukas; John D. Reveille; Xiaodong Zhou; Anne Marie Sims; Alison Dowling; Jacqueline Taylor; Tracy Doan; John C. Davis; Laurie Savage; Michael M. Ward; Thomas L. Learch; Michael H. Weisman; Samantha Hider

doi:10.1038/ng.2007.17

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

Paul R. Burton, David G. Clayton, Lon R. Cardon, Nick Craddock, Audrey Duncanson, Dominic P. Kwiatkowski, Mark I. McCarthy, Willem H. Ouwehand, Nilesh J. Samani, John A. Todd, Peter Donnelly, Jeffrey C. Barrett, Dan Davison, Doug Easton, David M. Evans, Hin Tak Leung, Jonathan L. Marchini, Andrew P. Morris, Chris C A Spencer, Martin D. TobinAntony P. Attwood, James P. Boorman, Barbara Cant, Ursula Everson, Judith M. Hussey, Jennifer D. Jolley, Alexandra S. Knight, Kerstin Koch, Elizabeth Meech, Sarah Nutland, Christopher V. Prowse, Helen E. Stevens, Niall C. Taylor, Graham R. Walters, Neil M. Walker, Nicholas A. Watkins, Thilo Winzer, Richard W. Jones, Wendy L. McArdle, Susan M. Ring, David P. Strachan, Marcus Pembrey, Gerome Breen, David St Clair, Sian Caesar, Katharine Gordon-Smith, Lisa Jones, Christine Fraser, Elaine K. Green, Detelina Grozeva, Marian L. Hamshere, Peter A. Holmans, Ian R. Jones, George Kirov, Valentina Moskivina, Ivan Nikolov, Michael C. O'Donovan, Michael J. Owen, David A. Collier, Amanda Elkin, Anne Farmer, Richard Williamson, Peter McGuffin, Allan H. Young, I. Nicol Ferrier, Stephen G. Ball, Anthony J. Balmforth, Jennifer H. Barrett, Timothy D. Bishop, Mark M. Iles, Azhar Maqbool, Nadira Yuldasheva, Alistair S. Hall, Peter S. Braund, Richard J. Dixon, Massimo Mangino, Suzanne Stevens, John R. Thompson, Francesca Bredin, Mark Tremelling, Miles Parkes, Hazel Drummond, Charles W. Lees, Elaine R. Nimmo, Jack Satsangi, Sheila A. Fisher, Alastair Forbes, Cathryn M. Lewis, Clive M. Onnie, Natalie J. Prescott, Jeremy Sanderson, Christopher G. Matthew, Jamie Barbour, M. Khalid Mohiuddin, Catherine E. Todhunter, John C. Mansfield, Tariq Ahmad, Fraser R. Cummings, Derek P. Jewell, John Webster, Morris J. Brown, Mark G. Lathrop, John Connell, Anna Dominiczak, Carolina A Braga Marcano, Beverley Burke, Richard Dobson, Johannie Gungadoo, Kate L. Lee, Patricia B. Munroe, Stephen J. Newhouse, Abiodun Onipinla, Chris Wallace, Mingzhan Xue, Mark Caulfield, Martin Farrall, Anne Barton, Ian N. Bruce, Hannah Donovan, Steve Eyre, Paul D. Gilbert, Samantha L. Hilder, Anne M. Hinks, Sally L. John, Catherine Potter, Alan J. Silman, Deborah P M Symmons, Wendy Thomson, Jane Worthington, David B. Dunger, Barry Widmer, Timothy M. Frayling, Rachel M. Freathy, Hana Lango, John R B Perry, Beverley M. Shields, Michael N. Weedon, Andrew T. Hattersley, Graham A. Hitman, Mark Walker, Kate S. Elliott, Christopher J. Groves, Cecilia M. Lindgren, Nigel W. Rayner, Nicolas J. Timpson, Eleftheria Zeggini, Melanie Newport, Giorgio Sirugo, Emily Lyons, Fredrik Vannberg, Adrian V S Hill, Linda A. Bradbury, Claire Farrar, Jennifer J. Pointon, Paul Wordsworth, Matthew A. Brown, Jayne A. Franklyn, Joanne M. Heward, Matthew J. Simmonds, Sheila Seal, Michael R. Stratton, Nazneen Rahman, Maria Ban, An Goris, Stephen J. Sawcer, Alastair Compston, David Conway, Muminatou Jallow, Kirk A. Rockett, Suzannah J. Bumpstead, Amy Chaney, Kate Downes, Mohammed J R Ghori, Rhian Gwilliam, Sarah E. Hunt, Michael Inouye, Emma King, Simon Potter, Rathi Ravindrarajah, Pamela Whittaker, Claire Widden, David Withers, Niall J. Cardin, Teresa Ferreira, Joanne Pereira-Gale, Ingeleif B. Hallgrimsdóttir, Bryan N. Howie, Zhan Su, Yik Ying Teo, Damjan Vukcevic, David Bentley, Sarah L. Mitchell, Paul R. Newby, Oliver J. Brand, Jackie Carr-Smith, Simon H S Pearce, Stephen C L Gough, R. McGinnis, A. Keniry, P. Deloukas, John D. Reveille, Xiaodong Zhou, Anne Marie Sims, Alison Dowling, Jacqueline Taylor, Tracy Doan, John C. Davis, Laurie Savage, Michael M. Ward, Thomas L. Learch, Michael H. Weisman, Samantha Hider

The University of Manchester

Research output: Contribution to journal › Article › peer-review

Abstract

We have genotyped 14,436 nonsynonymous SNPs (nsSNPs) and 897 major histocompatibility complex (MHC) tag SNPs from 1,000 independent cases of ankylosing spondylitis (AS), autoimmune thyroid disease (AITD), multiple sclerosis (MS) and breast cancer (BC). Comparing these data against a common control dataset derived from 1,500 randomly selected healthy British individuals, we report initial association and independent replication in a North American sample of two new loci related to ankylosing spondylitis, ARTS1 and IL23R, and confirmation of the previously reported association of AITD with TSHR and FCRL3. These findings, enabled in part by increased statistical power resulting from the expansion of the control reference group to include individuals from the other disease groups, highlight notable new possibilities for autoimmune regulation and suggest that IL23R may be a common susceptibility factor for the major 'seronegative' diseases. © 2007 Nature Publishing Group.

Original language	English
Pages (from-to)	1329-1337
Number of pages	8
Journal	Nature Genetics
Volume	39
Issue number	11
DOIs	https://doi.org/10.1038/ng.2007.17
Publication status	Published - Nov 2007

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10.1038/ng.2007.17

Cite this

Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., Ouwehand, W. H., Samani, N. J., Todd, J. A., Donnelly, P., Barrett, J. C., Davison, D., Easton, D., Evans, D. M., Leung, H. T., Marchini, J. L., Morris, A. P., Spencer, C. C. A., ... Hider, S. (2007). Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nature Genetics, 39(11), 1329-1337. https://doi.org/10.1038/ng.2007.17

@article{68149a9edc3e440bb7ad605a11625e24,

title = "Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants",

abstract = "We have genotyped 14,436 nonsynonymous SNPs (nsSNPs) and 897 major histocompatibility complex (MHC) tag SNPs from 1,000 independent cases of ankylosing spondylitis (AS), autoimmune thyroid disease (AITD), multiple sclerosis (MS) and breast cancer (BC). Comparing these data against a common control dataset derived from 1,500 randomly selected healthy British individuals, we report initial association and independent replication in a North American sample of two new loci related to ankylosing spondylitis, ARTS1 and IL23R, and confirmation of the previously reported association of AITD with TSHR and FCRL3. These findings, enabled in part by increased statistical power resulting from the expansion of the control reference group to include individuals from the other disease groups, highlight notable new possibilities for autoimmune regulation and suggest that IL23R may be a common susceptibility factor for the major 'seronegative' diseases. {\textcopyright} 2007 Nature Publishing Group.",

author = "Burton, {Paul R.} and Clayton, {David G.} and Cardon, {Lon R.} and Nick Craddock and Audrey Duncanson and Kwiatkowski, {Dominic P.} and McCarthy, {Mark I.} and Ouwehand, {Willem H.} and Samani, {Nilesh J.} and Todd, {John A.} and Peter Donnelly and Barrett, {Jeffrey C.} and Dan Davison and Doug Easton and Evans, {David M.} and Leung, {Hin Tak} and Marchini, {Jonathan L.} and Morris, {Andrew P.} and Spencer, {Chris C A} and Tobin, {Martin D.} and Attwood, {Antony P.} and Boorman, {James P.} and Barbara Cant and Ursula Everson and Hussey, {Judith M.} and Jolley, {Jennifer D.} and Knight, {Alexandra S.} and Kerstin Koch and Elizabeth Meech and Sarah Nutland and Prowse, {Christopher V.} and Stevens, {Helen E.} and Taylor, {Niall C.} and Walters, {Graham R.} and Walker, {Neil M.} and Watkins, {Nicholas A.} and Thilo Winzer and Jones, {Richard W.} and McArdle, {Wendy L.} and Ring, {Susan M.} and Strachan, {David P.} and Marcus Pembrey and Gerome Breen and Clair, {David St} and Sian Caesar and Katharine Gordon-Smith and Lisa Jones and Christine Fraser and Green, {Elaine K.} and Detelina Grozeva and Hamshere, {Marian L.} and Holmans, {Peter A.} and Jones, {Ian R.} and George Kirov and Valentina Moskivina and Ivan Nikolov and O'Donovan, {Michael C.} and Owen, {Michael J.} and Collier, {David A.} and Amanda Elkin and Anne Farmer and Richard Williamson and Peter McGuffin and Young, {Allan H.} and Ferrier, {I. Nicol} and Ball, {Stephen G.} and Balmforth, {Anthony J.} and Barrett, {Jennifer H.} and Bishop, {Timothy D.} and Iles, {Mark M.} and Azhar Maqbool and Nadira Yuldasheva and Hall, {Alistair S.} and Braund, {Peter S.} and Dixon, {Richard J.} and Massimo Mangino and Suzanne Stevens and Thompson, {John R.} and Francesca Bredin and Mark Tremelling and Miles Parkes and Hazel Drummond and Lees, {Charles W.} and Nimmo, {Elaine R.} and Jack Satsangi and Fisher, {Sheila A.} and Alastair Forbes and Lewis, {Cathryn M.} and Onnie, {Clive M.} and Prescott, {Natalie J.} and Jeremy Sanderson and Matthew, {Christopher G.} and Jamie Barbour and Mohiuddin, {M. Khalid} and Todhunter, {Catherine E.} and Mansfield, {John C.} and Tariq Ahmad and Cummings, {Fraser R.} and Jewell, {Derek P.} and John Webster and Brown, {Morris J.} and Lathrop, {Mark G.} and John Connell and Anna Dominiczak and Marcano, {Carolina A Braga} and Beverley Burke and Richard Dobson and Johannie Gungadoo and Lee, {Kate L.} and Munroe, {Patricia B.} and Newhouse, {Stephen J.} and Abiodun Onipinla and Chris Wallace and Mingzhan Xue and Mark Caulfield and Martin Farrall and Anne Barton and Bruce, {Ian N.} and Hannah Donovan and Steve Eyre and Gilbert, {Paul D.} and Hilder, {Samantha L.} and Hinks, {Anne M.} and John, {Sally L.} and Catherine Potter and Silman, {Alan J.} and Symmons, {Deborah P M} and Wendy Thomson and Jane Worthington and Dunger, {David B.} and Barry Widmer and Frayling, {Timothy M.} and Freathy, {Rachel M.} and Hana Lango and Perry, {John R B} and Shields, {Beverley M.} and Weedon, {Michael N.} and Hattersley, {Andrew T.} and Hitman, {Graham A.} and Mark Walker and Elliott, {Kate S.} and Groves, {Christopher J.} and Lindgren, {Cecilia M.} and Rayner, {Nigel W.} and Timpson, {Nicolas J.} and Eleftheria Zeggini and Melanie Newport and Giorgio Sirugo and Emily Lyons and Fredrik Vannberg and Hill, {Adrian V S} and Bradbury, {Linda A.} and Claire Farrar and Pointon, {Jennifer J.} and Paul Wordsworth and Brown, {Matthew A.} and Franklyn, {Jayne A.} and Heward, {Joanne M.} and Simmonds, {Matthew J.} and Sheila Seal and Stratton, {Michael R.} and Nazneen Rahman and Maria Ban and An Goris and Sawcer, {Stephen J.} and Alastair Compston and David Conway and Muminatou Jallow and Rockett, {Kirk A.} and Bumpstead, {Suzannah J.} and Amy Chaney and Kate Downes and Ghori, {Mohammed J R} and Rhian Gwilliam and Hunt, {Sarah E.} and Michael Inouye and Emma King and Simon Potter and Rathi Ravindrarajah and Pamela Whittaker and Claire Widden and David Withers and Cardin, {Niall J.} and Teresa Ferreira and Joanne Pereira-Gale and Hallgrimsd{\'o}ttir, {Ingeleif B.} and Howie, {Bryan N.} and Zhan Su and Teo, {Yik Ying} and Damjan Vukcevic and David Bentley and Mitchell, {Sarah L.} and Newby, {Paul R.} and Brand, {Oliver J.} and Jackie Carr-Smith and Pearce, {Simon H S} and Gough, {Stephen C L} and R. McGinnis and A. Keniry and P. Deloukas and Reveille, {John D.} and Xiaodong Zhou and Sims, {Anne Marie} and Alison Dowling and Jacqueline Taylor and Tracy Doan and Davis, {John C.} and Laurie Savage and Ward, {Michael M.} and Learch, {Thomas L.} and Weisman, {Michael H.} and Samantha Hider",

year = "2007",

month = nov,

doi = "10.1038/ng.2007.17",

language = "English",

volume = "39",

pages = "1329--1337",

journal = "Nature Genetics",

issn = "1061-4036",

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Burton, PR, Clayton, DG, Cardon, LR, Craddock, N, Duncanson, A, Kwiatkowski, DP, McCarthy, MI, Ouwehand, WH, Samani, NJ, Todd, JA, Donnelly, P, Barrett, JC, Davison, D, Easton, D, Evans, DM, Leung, HT, Marchini, JL, Morris, AP, Spencer, CCA, Tobin, MD, Attwood, AP, Boorman, JP, Cant, B, Everson, U, Hussey, JM, Jolley, JD, Knight, AS, Koch, K, Meech, E, Nutland, S, Prowse, CV, Stevens, HE, Taylor, NC, Walters, GR, Walker, NM, Watkins, NA, Winzer, T, Jones, RW, McArdle, WL, Ring, SM, Strachan, DP, Pembrey, M, Breen, G, Clair, DS, Caesar, S, Gordon-Smith, K, Jones, L, Fraser, C, Green, EK, Grozeva, D, Hamshere, ML, Holmans, PA, Jones, IR, Kirov, G, Moskivina, V, Nikolov, I, O'Donovan, MC, Owen, MJ, Collier, DA, Elkin, A, Farmer, A, Williamson, R, McGuffin, P, Young, AH, Ferrier, IN, Ball, SG, Balmforth, AJ, Barrett, JH, Bishop, TD, Iles, MM, Maqbool, A, Yuldasheva, N, Hall, AS, Braund, PS, Dixon, RJ, Mangino, M, Stevens, S, Thompson, JR, Bredin, F, Tremelling, M, Parkes, M, Drummond, H, Lees, CW, Nimmo, ER, Satsangi, J, Fisher, SA, Forbes, A, Lewis, CM, Onnie, CM, Prescott, NJ, Sanderson, J, Matthew, CG, Barbour, J, Mohiuddin, MK, Todhunter, CE, Mansfield, JC, Ahmad, T, Cummings, FR, Jewell, DP, Webster, J, Brown, MJ, Lathrop, MG, Connell, J, Dominiczak, A, Marcano, CAB, Burke, B, Dobson, R, Gungadoo, J, Lee, KL, Munroe, PB, Newhouse, SJ, Onipinla, A, Wallace, C, Xue, M, Caulfield, M, Farrall, M, Barton, A , Bruce, IN, Donovan, H, Eyre, S, Gilbert, PD, Hilder, SL, Hinks, AM, John, SL, Potter, C, Silman, AJ, Symmons, DPM , Thomson, W , Worthington, J, Dunger, DB, Widmer, B, Frayling, TM, Freathy, RM, Lango, H, Perry, JRB, Shields, BM, Weedon, MN, Hattersley, AT, Hitman, GA, Walker, M, Elliott, KS, Groves, CJ, Lindgren, CM, Rayner, NW, Timpson, NJ, Zeggini, E, Newport, M, Sirugo, G, Lyons, E, Vannberg, F, Hill, AVS, Bradbury, LA, Farrar, C, Pointon, JJ, Wordsworth, P, Brown, MA, Franklyn, JA, Heward, JM, Simmonds, MJ, Seal, S, Stratton, MR, Rahman, N, Ban, M, Goris, A, Sawcer, SJ, Compston, A, Conway, D, Jallow, M, Rockett, KA, Bumpstead, SJ, Chaney, A, Downes, K, Ghori, MJR, Gwilliam, R, Hunt, SE, Inouye, M, King, E, Potter, S, Ravindrarajah, R, Whittaker, P, Widden, C, Withers, D, Cardin, NJ, Ferreira, T, Pereira-Gale, J, Hallgrimsdóttir, IB, Howie, BN, Su, Z, Teo, YY, Vukcevic, D, Bentley, D, Mitchell, SL, Newby, PR, Brand, OJ, Carr-Smith, J, Pearce, SHS, Gough, SCL, McGinnis, R, Keniry, A, Deloukas, P, Reveille, JD, Zhou, X, Sims, AM, Dowling, A, Taylor, J, Doan, T, Davis, JC, Savage, L, Ward, MM, Learch, TL, Weisman, MH & Hider, S 2007, 'Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants', Nature Genetics, vol. 39, no. 11, pp. 1329-1337. https://doi.org/10.1038/ng.2007.17

TY - JOUR

T1 - Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

AU - Burton, Paul R.

AU - Clayton, David G.

AU - Cardon, Lon R.

AU - Craddock, Nick

AU - Duncanson, Audrey

AU - Kwiatkowski, Dominic P.

AU - McCarthy, Mark I.

AU - Ouwehand, Willem H.

AU - Samani, Nilesh J.

AU - Todd, John A.

AU - Donnelly, Peter

AU - Barrett, Jeffrey C.

AU - Davison, Dan

AU - Easton, Doug

AU - Evans, David M.

AU - Leung, Hin Tak

AU - Marchini, Jonathan L.

AU - Morris, Andrew P.

AU - Spencer, Chris C A

AU - Tobin, Martin D.

AU - Attwood, Antony P.

AU - Boorman, James P.

AU - Cant, Barbara

AU - Everson, Ursula

AU - Hussey, Judith M.

AU - Jolley, Jennifer D.

AU - Knight, Alexandra S.

AU - Koch, Kerstin

AU - Meech, Elizabeth

AU - Nutland, Sarah

AU - Prowse, Christopher V.

AU - Stevens, Helen E.

AU - Taylor, Niall C.

AU - Walters, Graham R.

AU - Walker, Neil M.

AU - Watkins, Nicholas A.

AU - Winzer, Thilo

AU - Jones, Richard W.

AU - McArdle, Wendy L.

AU - Ring, Susan M.

AU - Strachan, David P.

AU - Pembrey, Marcus

AU - Breen, Gerome

AU - Clair, David St

AU - Caesar, Sian

AU - Gordon-Smith, Katharine

AU - Jones, Lisa

AU - Fraser, Christine

AU - Green, Elaine K.

AU - Grozeva, Detelina

AU - Hamshere, Marian L.

AU - Holmans, Peter A.

AU - Jones, Ian R.

AU - Kirov, George

AU - Moskivina, Valentina

AU - Nikolov, Ivan

AU - O'Donovan, Michael C.

AU - Owen, Michael J.

AU - Collier, David A.

AU - Elkin, Amanda

AU - Farmer, Anne

AU - Williamson, Richard

AU - McGuffin, Peter

AU - Young, Allan H.

AU - Ferrier, I. Nicol

AU - Ball, Stephen G.

AU - Balmforth, Anthony J.

AU - Barrett, Jennifer H.

AU - Bishop, Timothy D.

AU - Iles, Mark M.

AU - Maqbool, Azhar

AU - Yuldasheva, Nadira

AU - Hall, Alistair S.

AU - Braund, Peter S.

AU - Dixon, Richard J.

AU - Mangino, Massimo

AU - Stevens, Suzanne

AU - Thompson, John R.

AU - Bredin, Francesca

AU - Tremelling, Mark

AU - Parkes, Miles

AU - Drummond, Hazel

AU - Lees, Charles W.

AU - Nimmo, Elaine R.

AU - Satsangi, Jack

AU - Fisher, Sheila A.

AU - Forbes, Alastair

AU - Lewis, Cathryn M.

AU - Onnie, Clive M.

AU - Prescott, Natalie J.

AU - Sanderson, Jeremy

AU - Matthew, Christopher G.

AU - Barbour, Jamie

AU - Mohiuddin, M. Khalid

AU - Todhunter, Catherine E.

AU - Mansfield, John C.

AU - Ahmad, Tariq

AU - Cummings, Fraser R.

AU - Jewell, Derek P.

AU - Webster, John

AU - Brown, Morris J.

AU - Lathrop, Mark G.

AU - Connell, John

AU - Dominiczak, Anna

AU - Marcano, Carolina A Braga

AU - Burke, Beverley

AU - Dobson, Richard

AU - Gungadoo, Johannie

AU - Lee, Kate L.

AU - Munroe, Patricia B.

AU - Newhouse, Stephen J.

AU - Onipinla, Abiodun

AU - Wallace, Chris

AU - Xue, Mingzhan

AU - Caulfield, Mark

AU - Farrall, Martin

AU - Barton, Anne

AU - Bruce, Ian N.

AU - Donovan, Hannah

AU - Eyre, Steve

AU - Gilbert, Paul D.

AU - Hilder, Samantha L.

AU - Hinks, Anne M.

AU - John, Sally L.

AU - Potter, Catherine

AU - Silman, Alan J.

AU - Symmons, Deborah P M

AU - Thomson, Wendy

AU - Worthington, Jane

AU - Dunger, David B.

AU - Widmer, Barry

AU - Frayling, Timothy M.

AU - Freathy, Rachel M.

AU - Lango, Hana

AU - Perry, John R B

AU - Shields, Beverley M.

AU - Weedon, Michael N.

AU - Hattersley, Andrew T.

AU - Hitman, Graham A.

AU - Walker, Mark

AU - Elliott, Kate S.

AU - Groves, Christopher J.

AU - Lindgren, Cecilia M.

AU - Rayner, Nigel W.

AU - Timpson, Nicolas J.

AU - Zeggini, Eleftheria

AU - Newport, Melanie

AU - Sirugo, Giorgio

AU - Lyons, Emily

AU - Vannberg, Fredrik

AU - Hill, Adrian V S

AU - Bradbury, Linda A.

AU - Farrar, Claire

AU - Pointon, Jennifer J.

AU - Wordsworth, Paul

AU - Brown, Matthew A.

AU - Franklyn, Jayne A.

AU - Heward, Joanne M.

AU - Simmonds, Matthew J.

AU - Seal, Sheila

AU - Stratton, Michael R.

AU - Rahman, Nazneen

AU - Ban, Maria

AU - Goris, An

AU - Sawcer, Stephen J.

AU - Compston, Alastair

AU - Conway, David

AU - Jallow, Muminatou

AU - Rockett, Kirk A.

AU - Bumpstead, Suzannah J.

AU - Chaney, Amy

AU - Downes, Kate

AU - Ghori, Mohammed J R

AU - Gwilliam, Rhian

AU - Hunt, Sarah E.

AU - Inouye, Michael

AU - King, Emma

AU - Potter, Simon

AU - Ravindrarajah, Rathi

AU - Whittaker, Pamela

AU - Widden, Claire

AU - Withers, David

AU - Cardin, Niall J.

AU - Ferreira, Teresa

AU - Pereira-Gale, Joanne

AU - Hallgrimsdóttir, Ingeleif B.

AU - Howie, Bryan N.

AU - Su, Zhan

AU - Teo, Yik Ying

AU - Vukcevic, Damjan

AU - Bentley, David

AU - Mitchell, Sarah L.

AU - Newby, Paul R.

AU - Brand, Oliver J.

AU - Carr-Smith, Jackie

AU - Pearce, Simon H S

AU - Gough, Stephen C L

AU - McGinnis, R.

AU - Keniry, A.

AU - Deloukas, P.

AU - Reveille, John D.

AU - Zhou, Xiaodong

AU - Sims, Anne Marie

AU - Dowling, Alison

AU - Taylor, Jacqueline

AU - Doan, Tracy

AU - Davis, John C.

AU - Savage, Laurie

AU - Ward, Michael M.

AU - Learch, Thomas L.

AU - Weisman, Michael H.

AU - Hider, Samantha

PY - 2007/11

Y1 - 2007/11

N2 - We have genotyped 14,436 nonsynonymous SNPs (nsSNPs) and 897 major histocompatibility complex (MHC) tag SNPs from 1,000 independent cases of ankylosing spondylitis (AS), autoimmune thyroid disease (AITD), multiple sclerosis (MS) and breast cancer (BC). Comparing these data against a common control dataset derived from 1,500 randomly selected healthy British individuals, we report initial association and independent replication in a North American sample of two new loci related to ankylosing spondylitis, ARTS1 and IL23R, and confirmation of the previously reported association of AITD with TSHR and FCRL3. These findings, enabled in part by increased statistical power resulting from the expansion of the control reference group to include individuals from the other disease groups, highlight notable new possibilities for autoimmune regulation and suggest that IL23R may be a common susceptibility factor for the major 'seronegative' diseases. © 2007 Nature Publishing Group.

AB - We have genotyped 14,436 nonsynonymous SNPs (nsSNPs) and 897 major histocompatibility complex (MHC) tag SNPs from 1,000 independent cases of ankylosing spondylitis (AS), autoimmune thyroid disease (AITD), multiple sclerosis (MS) and breast cancer (BC). Comparing these data against a common control dataset derived from 1,500 randomly selected healthy British individuals, we report initial association and independent replication in a North American sample of two new loci related to ankylosing spondylitis, ARTS1 and IL23R, and confirmation of the previously reported association of AITD with TSHR and FCRL3. These findings, enabled in part by increased statistical power resulting from the expansion of the control reference group to include individuals from the other disease groups, highlight notable new possibilities for autoimmune regulation and suggest that IL23R may be a common susceptibility factor for the major 'seronegative' diseases. © 2007 Nature Publishing Group.

U2 - 10.1038/ng.2007.17

DO - 10.1038/ng.2007.17

M3 - Article

SN - 1061-4036

VL - 39

SP - 1329

EP - 1337

JO - Nature Genetics

JF - Nature Genetics

IS - 11

ER -

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

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