Association study of the GAB2 gene with the risk of developing Alzheimer's disease

Julien Chapuis; Didier Hannequin; Florence Pasquier; Peter Bentham; Alexis Brice; Isabelle Leber; Thierry Frebourg; Jean François Deleuze; Emmanuelle Cousin; Uma Thaker; Philippe Amouyel; David Mann; Corinne Lendon; Dominique Campion; Jean Charles Lambert

doi:10.1016/j.nbd.2007.12.006

Association study of the GAB2 gene with the risk of developing Alzheimer's disease

Julien Chapuis, Didier Hannequin, Florence Pasquier, Peter Bentham, Alexis Brice, Isabelle Leber, Thierry Frebourg, Jean François Deleuze, Emmanuelle Cousin, Uma Thaker, Philippe Amouyel, David Mann, Corinne Lendon, Dominique Campion, Jean Charles Lambert

Research output: Contribution to journal › Article › peer-review

Abstract

The first genome-wide association in Alzheimer's disease (AD) suggested that the GAB2 gene rs2373115 polymorphism may be a strong risk factor in APOE e{open}4-carriers. We failed to detect an association of rs2373115 with the risk of developing AD in three populations (totalling 1406 controls and 1749 AD cases) whatever the APOE status, even if we observed a slight tendency for an increase of the GG genotype (OR (GG versus GT + TT) = 1.3, 95% CI 1.0-1.6, p = 0.09) and the G allele frequency (OR = 1.3, 95%CI 1.0-1.6, p = 0.05) in e{open}4-carriers. In addition, the rs2373115 did not modulate the extent of tau phosphorylation in the brain of 89 AD cases. The GAB2 gene is at best a minor genetic determinant of AD. © 2008 Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	103-106
Number of pages	3
Journal	Neurobiology of disease
Volume	30
Issue number	1
DOIs	https://doi.org/10.1016/j.nbd.2007.12.006
Publication status	Published - Apr 2008

Keywords

Alzheimer
APOE
GAB2
Polymorphism

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Chapuis, J., Hannequin, D., Pasquier, F., Bentham, P., Brice, A., Leber, I., Frebourg, T., Deleuze, J. F., Cousin, E., Thaker, U., Amouyel, P., Mann, D., Lendon, C., Campion, D., & Lambert, J. C. (2008). Association study of the GAB2 gene with the risk of developing Alzheimer's disease. Neurobiology of disease, 30(1), 103-106. https://doi.org/10.1016/j.nbd.2007.12.006

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title = "Association study of the GAB2 gene with the risk of developing Alzheimer's disease",

abstract = "The first genome-wide association in Alzheimer's disease (AD) suggested that the GAB2 gene rs2373115 polymorphism may be a strong risk factor in APOE e{open}4-carriers. We failed to detect an association of rs2373115 with the risk of developing AD in three populations (totalling 1406 controls and 1749 AD cases) whatever the APOE status, even if we observed a slight tendency for an increase of the GG genotype (OR (GG versus GT + TT) = 1.3, 95% CI 1.0-1.6, p = 0.09) and the G allele frequency (OR = 1.3, 95%CI 1.0-1.6, p = 0.05) in e{open}4-carriers. In addition, the rs2373115 did not modulate the extent of tau phosphorylation in the brain of 89 AD cases. The GAB2 gene is at best a minor genetic determinant of AD. {\textcopyright} 2008 Elsevier Inc. All rights reserved.",

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author = "Julien Chapuis and Didier Hannequin and Florence Pasquier and Peter Bentham and Alexis Brice and Isabelle Leber and Thierry Frebourg and Deleuze, {Jean Fran{\c c}ois} and Emmanuelle Cousin and Uma Thaker and Philippe Amouyel and David Mann and Corinne Lendon and Dominique Campion and Lambert, {Jean Charles}",

year = "2008",

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doi = "10.1016/j.nbd.2007.12.006",

language = "English",

volume = "30",

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AU - Chapuis, Julien

AU - Hannequin, Didier

AU - Pasquier, Florence

AU - Bentham, Peter

AU - Brice, Alexis

AU - Leber, Isabelle

AU - Frebourg, Thierry

AU - Deleuze, Jean François

AU - Cousin, Emmanuelle

AU - Thaker, Uma

AU - Amouyel, Philippe

AU - Mann, David

AU - Lendon, Corinne

AU - Campion, Dominique

AU - Lambert, Jean Charles

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N2 - The first genome-wide association in Alzheimer's disease (AD) suggested that the GAB2 gene rs2373115 polymorphism may be a strong risk factor in APOE e{open}4-carriers. We failed to detect an association of rs2373115 with the risk of developing AD in three populations (totalling 1406 controls and 1749 AD cases) whatever the APOE status, even if we observed a slight tendency for an increase of the GG genotype (OR (GG versus GT + TT) = 1.3, 95% CI 1.0-1.6, p = 0.09) and the G allele frequency (OR = 1.3, 95%CI 1.0-1.6, p = 0.05) in e{open}4-carriers. In addition, the rs2373115 did not modulate the extent of tau phosphorylation in the brain of 89 AD cases. The GAB2 gene is at best a minor genetic determinant of AD. © 2008 Elsevier Inc. All rights reserved.

AB - The first genome-wide association in Alzheimer's disease (AD) suggested that the GAB2 gene rs2373115 polymorphism may be a strong risk factor in APOE e{open}4-carriers. We failed to detect an association of rs2373115 with the risk of developing AD in three populations (totalling 1406 controls and 1749 AD cases) whatever the APOE status, even if we observed a slight tendency for an increase of the GG genotype (OR (GG versus GT + TT) = 1.3, 95% CI 1.0-1.6, p = 0.09) and the G allele frequency (OR = 1.3, 95%CI 1.0-1.6, p = 0.05) in e{open}4-carriers. In addition, the rs2373115 did not modulate the extent of tau phosphorylation in the brain of 89 AD cases. The GAB2 gene is at best a minor genetic determinant of AD. © 2008 Elsevier Inc. All rights reserved.

KW - Alzheimer

KW - APOE

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KW - Polymorphism

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DO - 10.1016/j.nbd.2007.12.006

M3 - Article

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SP - 103

EP - 106

JO - Neurobiology of disease

JF - Neurobiology of disease

IS - 1

ER -

Association study of the GAB2 gene with the risk of developing Alzheimer's disease

Abstract

Keywords

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