Association study of the Ubiquilin gene with Alzheimer's disease

Faiza Bensemain; Julien Chapuis; Jinzhou Tian; Jing Shi; Uma Thaker; Corinne Lendon; Takeshi Iwatsubo; Philippe Amouyel; David Mann; Jean Charles Lambert

doi:10.1016/j.nbd.2006.01.007

Association study of the Ubiquilin gene with Alzheimer's disease

Faiza Bensemain, Julien Chapuis, Jinzhou Tian, Jing Shi, Uma Thaker, Corinne Lendon, Takeshi Iwatsubo, Philippe Amouyel, David Mann, Jean Charles Lambert

Research output: Contribution to journal › Article › peer-review

Abstract

Recently, the ubiquilin 1 gene has been proposed as a major candidate gene for AD. Here, we have investigated the potential impact of the UBQ-8i polymorphism (rs12344615) within this gene on the risk of developing AD. No association of this polymorphism with the disease was observed in a large French case-control population. Furthermore, no relationship between this polymorphism and Aβ load or degree of neurofibrillary degeneration in the brains of 114 patients with AD was detected. © 2006 Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	691-693
Number of pages	2
Journal	Neurobiology of disease
Volume	22
Issue number	3
DOIs	https://doi.org/10.1016/j.nbd.2006.01.007
Publication status	Published - Jun 2006

Keywords

Alzheimer
Genetic determinant
Polymorphism
Splicing
Ubiquilin

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title = "Association study of the Ubiquilin gene with Alzheimer's disease",

abstract = "Recently, the ubiquilin 1 gene has been proposed as a major candidate gene for AD. Here, we have investigated the potential impact of the UBQ-8i polymorphism (rs12344615) within this gene on the risk of developing AD. No association of this polymorphism with the disease was observed in a large French case-control population. Furthermore, no relationship between this polymorphism and Aβ load or degree of neurofibrillary degeneration in the brains of 114 patients with AD was detected. {\textcopyright} 2006 Elsevier Inc. All rights reserved.",

keywords = "Alzheimer, Genetic determinant, Polymorphism, Splicing, Ubiquilin",

author = "Faiza Bensemain and Julien Chapuis and Jinzhou Tian and Jing Shi and Uma Thaker and Corinne Lendon and Takeshi Iwatsubo and Philippe Amouyel and David Mann and Lambert, {Jean Charles}",

year = "2006",

month = jun,

doi = "10.1016/j.nbd.2006.01.007",

language = "English",

volume = "22",

pages = "691--693",

journal = "Neurobiology of disease",

issn = "0969-9961",

publisher = "Elsevier BV",

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TY - JOUR

T1 - Association study of the Ubiquilin gene with Alzheimer's disease

AU - Bensemain, Faiza

AU - Chapuis, Julien

AU - Tian, Jinzhou

AU - Shi, Jing

AU - Thaker, Uma

AU - Lendon, Corinne

AU - Iwatsubo, Takeshi

AU - Amouyel, Philippe

AU - Mann, David

AU - Lambert, Jean Charles

PY - 2006/6

Y1 - 2006/6

N2 - Recently, the ubiquilin 1 gene has been proposed as a major candidate gene for AD. Here, we have investigated the potential impact of the UBQ-8i polymorphism (rs12344615) within this gene on the risk of developing AD. No association of this polymorphism with the disease was observed in a large French case-control population. Furthermore, no relationship between this polymorphism and Aβ load or degree of neurofibrillary degeneration in the brains of 114 patients with AD was detected. © 2006 Elsevier Inc. All rights reserved.

AB - Recently, the ubiquilin 1 gene has been proposed as a major candidate gene for AD. Here, we have investigated the potential impact of the UBQ-8i polymorphism (rs12344615) within this gene on the risk of developing AD. No association of this polymorphism with the disease was observed in a large French case-control population. Furthermore, no relationship between this polymorphism and Aβ load or degree of neurofibrillary degeneration in the brains of 114 patients with AD was detected. © 2006 Elsevier Inc. All rights reserved.

KW - Alzheimer

KW - Genetic determinant

KW - Polymorphism

KW - Splicing

KW - Ubiquilin

U2 - 10.1016/j.nbd.2006.01.007

DO - 10.1016/j.nbd.2006.01.007

M3 - Article

SN - 0969-9961

VL - 22

SP - 691

EP - 693

JO - Neurobiology of disease

JF - Neurobiology of disease

IS - 3

ER -

Association study of the Ubiquilin gene with Alzheimer's disease

Abstract

Keywords

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