Associations between demographic and disease-related variables and disability over the first five years of inflammatory polyarthritis: A longitudinal analysis using generalized estimating equations

Nicola Wiles, Graham Dunn, Elizabeth Barrett, Alan Silman, Deborah Symmons

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Objectives: To investigate whether the relationship between demographic and disease-related variables and disability is constant during the first five years of inflammatory polyarthritis (IP) and to identify the contribution from involvement of specific joint areas to overall disability. Methods: 684 patients referred to the Norfolk Arthritis Register were followed for five years using the Health Assessment Questionnaire (HAQ). The relationship between disability and demographic and clinical variables was analyzed using a multi-level modelling approach. Results: Female gender, older age at symptom onset (≥ 64 years), joint involvement at six specific sites, joint tenderness and the number of deformed joints were all independently associated with disability (HAQ ≥ 1.00). Similar results were obtained using a more stringent cut-off (HAQ ≥ 1.50) or when analysis was restricted to the 325 patients who satisfied the 1987 ARA list criteria for rheumatoid arthritis. Conclusion: Disability, as measured by the HAQ, was associated with a large number of independent factors over the first five years of disease. (C) 2000 Elsevier Science Inc.
    Original languageEnglish
    Pages (from-to)988-996
    Number of pages8
    JournalJournal of Clinical Epidemiology
    Volume53
    Issue number10
    DOIs
    Publication statusPublished - Oct 2000

    Keywords

    • Disability
    • Generalized estimating equations
    • Health assessment questionnaire
    • Longitudinal analysis
    • Rheumatoid arthritis

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