Asthma similarities across ProAR (Brazil) and U-BIOPRED (Europe) adult cohorts of contrasting locations, ethnicity and socioeconomic status

A.A. Cruz; J.H. Riley; A.T. Bansal; E.V. Ponte; A. Souza-Machado; P.C.A. Almeida; V. Biao-Lima; M. Davis; S. Bates; I.M. Adcock; P.J. Sterk; K.F. Chung; N. Alcantara-Neves; P.C.A. Almeida; L. Amorim; M.I. Araujo; K.C. Barnes; M.L. Barreto; E. Belitardo; V. Bião-Lima; L. Cardoso; P.A. Camargos; J.M. Chatkin; R.S. Costa; A.C.C. Coelho; P.J. Cooper; A.A. Cruz; C.S. Cruz; J. Cunha; J.V. de Jesus; J. Fernandes; R.A. Franco; I. Gomes-Filho; A. Lima-Matos; C.A. Figueiredo; M.A. Lessa; L. Lins; L.M. Mello; P. Moura-Santos; I.S. Muniz; I. Paixao-Araujo; G.P. Pinheiro; E.V. Ponte; L.C. Rodrigues; C.V.N. Santana; G. Santos-Lima; T.M.O. Souza; A. Souza-Machado; C. Souza-Machado; R. Stelmach; V.S. Vasquez; I.M. Adcock; H. Ahmed; C. Auffray; P. Bakke; F. Baribaud; E.H. Bel; J. Bigler; H. Bisgaard; M.J. Boedigheimer; K. Bønnelykke; J. Brandsma; P. Brinkman; E. Bucchioni; D. Burg; A. Bush; M. Caruso; A. Chaiboonchoe; P. Chanez; C.H. Compton; J. Corfield; A. D'Amico; B. Dahlén; S.E. Dahlén; B. De Meulder; R. Djukanovic; V.J. Erpenbeck; D. Erzen; K. Fichtner; N. Fitch; L.J. Fleming; E. Formaggio; S.J. Fowler; U. Frey; M. Gahlemann; T. Geiser; V. Goss; Y.-K. Guo; S. Hashimoto; J. Haughney; G. Hedlin; P.W. Hekking; T. Higenbottam; J.M. Hohlfeld; C. Holweg; I. Horváth; P. Howarth; A.J. James; R.G. Knowles; A.J. Knox; N. Krug; D. Lefaudeux; M.J. Loza; R. Lutter; A. Manta; S. Masefield; J.G. Matthews; A. Mazein; A. Meiser; R.J.M. Middelveld; M. Miralpeix; P. Montuschi; N. Mores; C.S. Murray; J. Musial; D. Myles; L. Pahus; I. Pandis; S. Pavlidis; A. Postle; P. Powel; G. Praticò; M. Puig Valls; N. Rao; A. Roberts; G. Roberts; A. Rowe; T. Sandström; J.P.R. Schofield; W. Seibold; A. Selby; D.E. Shaw; R. Sigmund; F. Singer; P.J. Skipp; A.R. Sousa; P.J. Sterk; K. Sun; B. Thornton; W.M. van Aalderen; M. van Geest; J. Vestbo; N.H. Vissing; A.H. Wagener; S.S. Wagers; Z. Weiszhart; C.E. Wheelock; S.J. Wilson

doi:10.1016/j.rmed.2019.105817

Asthma similarities across ProAR (Brazil) and U-BIOPRED (Europe) adult cohorts of contrasting locations, ethnicity and socioeconomic status

A.A. Cruz, J.H. Riley, A.T. Bansal, E.V. Ponte, A. Souza-Machado, P.C.A. Almeida, V. Biao-Lima, M. Davis, S. Bates, I.M. Adcock, P.J. Sterk, K.F. Chung, N. Alcantara-Neves, P.C.A. Almeida, L. Amorim, M.I. Araujo, K.C. Barnes, M.L. Barreto, E. Belitardo, V. Bião-LimaL. Cardoso, P.A. Camargos, J.M. Chatkin, R.S. Costa, A.C.C. Coelho, P.J. Cooper, A.A. Cruz, C.S. Cruz, J. Cunha, J.V. de Jesus, J. Fernandes, R.A. Franco, I. Gomes-Filho, A. Lima-Matos, C.A. Figueiredo, M.A. Lessa, L. Lins, L.M. Mello, P. Moura-Santos, I.S. Muniz, I. Paixao-Araujo, G.P. Pinheiro, E.V. Ponte, L.C. Rodrigues, C.V.N. Santana, G. Santos-Lima, T.M.O. Souza, A. Souza-Machado, C. Souza-Machado, R. Stelmach, V.S. Vasquez, I.M. Adcock, H. Ahmed, C. Auffray, P. Bakke, F. Baribaud, E.H. Bel, J. Bigler, H. Bisgaard, M.J. Boedigheimer, K. Bønnelykke, J. Brandsma, P. Brinkman, E. Bucchioni, D. Burg, A. Bush, M. Caruso, A. Chaiboonchoe, P. Chanez, C.H. Compton, J. Corfield, A. D'Amico, B. Dahlén, S.E. Dahlén, B. De Meulder, R. Djukanovic, V.J. Erpenbeck, D. Erzen, K. Fichtner, N. Fitch, L.J. Fleming, E. Formaggio, S.J. Fowler, U. Frey, M. Gahlemann, T. Geiser, V. Goss, Y.-K. Guo, S. Hashimoto, J. Haughney, G. Hedlin, P.W. Hekking, T. Higenbottam, J.M. Hohlfeld, C. Holweg, I. Horváth, P. Howarth, A.J. James, R.G. Knowles, A.J. Knox, N. Krug, D. Lefaudeux, M.J. Loza, R. Lutter, A. Manta, S. Masefield, J.G. Matthews, A. Mazein, A. Meiser, R.J.M. Middelveld, M. Miralpeix, P. Montuschi, N. Mores, C.S. Murray, J. Musial, D. Myles, L. Pahus, I. Pandis, S. Pavlidis, A. Postle, P. Powel, G. Praticò, M. Puig Valls, N. Rao, A. Roberts, G. Roberts, A. Rowe, T. Sandström, J.P.R. Schofield, W. Seibold, A. Selby, D.E. Shaw, R. Sigmund, F. Singer, P.J. Skipp, A.R. Sousa, P.J. Sterk, K. Sun, B. Thornton, W.M. van Aalderen, M. van Geest, J. Vestbo, N.H. Vissing, A.H. Wagener, S.S. Wagers, Z. Weiszhart, C.E. Wheelock, S.J. Wilson

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Asthma prevalence is 339 million globally. ‘Severe asthma’ (SA) comprises subjects with uncontrolled asthma despite proper management. Objectives: To compare asthma from diverse ethnicities and environments. Methods: A cross-sectional analysis of two adult cohorts, a Brazilian (ProAR) and a European (U-BIOPRED). U-BIOPRED comprised of 311 non-smoking with Severe Asthma (SAn), 110 smokers or ex-smokers with SA (SAs) and 88 mild to moderate asthmatics (MMA) while ProAR included 544 SA and 452 MMA. Although these projects were independent, there were similarities in objectives and methodology, with ProAR adopting operating procedures of U-BIOPRED. Results: Among SA subjects, age, weight, proportion of former smokers and FEV ₁ pre-bronchodilator were similar. The proportion of SA with a positive skin prick tests (SPT) to aeroallergens, the scores of sino-nasal symptoms and quality of life were comparable. In addition, blood eosinophil counts (EOS) and the % of subjects with EOS > 300 cells/μl were not different. The Europeans with SA however, were more severe with a greater proportion of continuous oral corticosteroids (OCS), worse symptoms and more frequent exacerbations. FEV ₁/FVC pre- and post-bronchodilator were lower among the Europeans. The MMA cohorts were less comparable in control and treatment, but similar in the proportion of allergic rhinitis, gastroesophageal reflux disease and EOS >3%. Conclusions: ProAR and U-BIOPRED cohorts, with varying severity, ethnicity and environment have similarities, which provide the basis for global external validation of asthma phenotypes. This should stimulate collaboration between asthma consortia with the aim of understanding SA, which will lead to better management.

Original language	English
Article number	105817
Journal	Respiratory Medicine
Volume	161
DOIs	https://doi.org/10.1016/j.rmed.2019.105817
Publication status	Published - 25 Nov 2019

Keywords

Asthma
Biomarkers
Cohort studies
Cross sectional study
Disease management
Phenotypes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.rmed.2019.105817

Cite this

Cruz, A. A., Riley, J. H., Bansal, A. T., Ponte, E. V., Souza-Machado, A., Almeida, P. C. A., Biao-Lima, V., Davis, M., Bates, S., Adcock, I. M., Sterk, P. J., Chung, K. F., Alcantara-Neves, N., Almeida, P. C. A., Amorim, L., Araujo, M. I., Barnes, K. C., Barreto, M. L., Belitardo, E., ... Wilson, S. J. (2019). Asthma similarities across ProAR (Brazil) and U-BIOPRED (Europe) adult cohorts of contrasting locations, ethnicity and socioeconomic status. Respiratory Medicine, 161, Article 105817. https://doi.org/10.1016/j.rmed.2019.105817

@article{1a2e84a4f49743ca9321115f7d7211e5,

title = "Asthma similarities across ProAR (Brazil) and U-BIOPRED (Europe) adult cohorts of contrasting locations, ethnicity and socioeconomic status",

abstract = "Background: Asthma prevalence is 339 million globally. {\textquoteleft}Severe asthma{\textquoteright} (SA) comprises subjects with uncontrolled asthma despite proper management. Objectives: To compare asthma from diverse ethnicities and environments. Methods: A cross-sectional analysis of two adult cohorts, a Brazilian (ProAR) and a European (U-BIOPRED). U-BIOPRED comprised of 311 non-smoking with Severe Asthma (SAn), 110 smokers or ex-smokers with SA (SAs) and 88 mild to moderate asthmatics (MMA) while ProAR included 544 SA and 452 MMA. Although these projects were independent, there were similarities in objectives and methodology, with ProAR adopting operating procedures of U-BIOPRED. Results: Among SA subjects, age, weight, proportion of former smokers and FEV 1 pre-bronchodilator were similar. The proportion of SA with a positive skin prick tests (SPT) to aeroallergens, the scores of sino-nasal symptoms and quality of life were comparable. In addition, blood eosinophil counts (EOS) and the % of subjects with EOS > 300 cells/μl were not different. The Europeans with SA however, were more severe with a greater proportion of continuous oral corticosteroids (OCS), worse symptoms and more frequent exacerbations. FEV 1/FVC pre- and post-bronchodilator were lower among the Europeans. The MMA cohorts were less comparable in control and treatment, but similar in the proportion of allergic rhinitis, gastroesophageal reflux disease and EOS >3%. Conclusions: ProAR and U-BIOPRED cohorts, with varying severity, ethnicity and environment have similarities, which provide the basis for global external validation of asthma phenotypes. This should stimulate collaboration between asthma consortia with the aim of understanding SA, which will lead to better management. ",

keywords = "Asthma, Biomarkers, Cohort studies, Cross sectional study, Disease management, Phenotypes",

author = "A.A. Cruz and J.H. Riley and A.T. Bansal and E.V. Ponte and A. Souza-Machado and P.C.A. Almeida and V. Biao-Lima and M. Davis and S. Bates and I.M. Adcock and P.J. Sterk and K.F. Chung and N. Alcantara-Neves and P.C.A. Almeida and L. Amorim and M.I. Araujo and K.C. Barnes and M.L. Barreto and E. Belitardo and V. Bi{\~a}o-Lima and L. Cardoso and P.A. Camargos and J.M. Chatkin and R.S. Costa and A.C.C. Coelho and P.J. Cooper and A.A. Cruz and C.S. Cruz and J. Cunha and {de Jesus}, J.V. and J. Fernandes and R.A. Franco and I. Gomes-Filho and A. Lima-Matos and C.A. Figueiredo and M.A. Lessa and L. Lins and L.M. Mello and P. Moura-Santos and I.S. Muniz and I. Paixao-Araujo and G.P. Pinheiro and E.V. Ponte and L.C. Rodrigues and C.V.N. Santana and G. Santos-Lima and T.M.O. Souza and A. Souza-Machado and C. Souza-Machado and R. Stelmach and V.S. Vasquez and I.M. Adcock and H. Ahmed and C. Auffray and P. Bakke and F. Baribaud and E.H. Bel and J. Bigler and H. Bisgaard and M.J. Boedigheimer and K. B{\o}nnelykke and J. Brandsma and P. Brinkman and E. Bucchioni and D. Burg and A. Bush and M. Caruso and A. Chaiboonchoe and P. Chanez and C.H. Compton and J. Corfield and A. D'Amico and B. Dahl{\'e}n and S.E. Dahl{\'e}n and {De Meulder}, B. and R. Djukanovic and V.J. Erpenbeck and D. Erzen and K. Fichtner and N. Fitch and L.J. Fleming and E. Formaggio and S.J. Fowler and U. Frey and M. Gahlemann and T. Geiser and V. Goss and Y.-K. Guo and S. Hashimoto and J. Haughney and G. Hedlin and P.W. Hekking and T. Higenbottam and J.M. Hohlfeld and C. Holweg and I. Horv{\'a}th and P. Howarth and A.J. James and R.G. Knowles and A.J. Knox and N. Krug and D. Lefaudeux and M.J. Loza and R. Lutter and A. Manta and S. Masefield and J.G. Matthews and A. Mazein and A. Meiser and R.J.M. Middelveld and M. Miralpeix and P. Montuschi and N. Mores and C.S. Murray and J. Musial and D. Myles and L. Pahus and I. Pandis and S. Pavlidis and A. Postle and P. Powel and G. Pratic{\`o} and {Puig Valls}, M. and N. Rao and A. Roberts and G. Roberts and A. Rowe and T. Sandstr{\"o}m and J.P.R. Schofield and W. Seibold and A. Selby and D.E. Shaw and R. Sigmund and F. Singer and P.J. Skipp and A.R. Sousa and P.J. Sterk and K. Sun and B. Thornton and {van Aalderen}, W.M. and {van Geest}, M. and J. Vestbo and N.H. Vissing and A.H. Wagener and S.S. Wagers and Z. Weiszhart and C.E. Wheelock and S.J. Wilson",

note = "Funding Information: For ProAR - Conselho Nacional de Desenvolvimento Cient{\'i}fico e Tecnol{\'o}gico do Brasil (CNPq) – Grant # 471057/2014-2 , Funda{\c c}{\~a}o de Amparo a Pesquisa do Estado da Bahia (FAPESB) and GlaxoSmilthKline investigator initiated grant. For U-BIOPRED - IMI EU funded project (no. 115010 ). Publisher Copyright: {\textcopyright} 2019 Copyright: Copyright 2019 Elsevier B.V., All rights reserved.",

year = "2019",

month = nov,

day = "25",

doi = "10.1016/j.rmed.2019.105817",

language = "English",

volume = "161",

journal = "Respiratory Medicine",

issn = "0954-6111",

publisher = "W.B. Saunders Co. Ltd",

}

Cruz, AA, Riley, JH, Bansal, AT, Ponte, EV, Souza-Machado, A, Almeida, PCA, Biao-Lima, V, Davis, M, Bates, S, Adcock, IM, Sterk, PJ, Chung, KF, Alcantara-Neves, N, Almeida, PCA, Amorim, L, Araujo, MI, Barnes, KC, Barreto, ML, Belitardo, E, Bião-Lima, V, Cardoso, L, Camargos, PA, Chatkin, JM, Costa, RS, Coelho, ACC, Cooper, PJ, Cruz, AA, Cruz, CS, Cunha, J, de Jesus, JV, Fernandes, J, Franco, RA, Gomes-Filho, I, Lima-Matos, A, Figueiredo, CA, Lessa, MA, Lins, L, Mello, LM, Moura-Santos, P, Muniz, IS, Paixao-Araujo, I, Pinheiro, GP, Ponte, EV, Rodrigues, LC, Santana, CVN, Santos-Lima, G, Souza, TMO, Souza-Machado, A, Souza-Machado, C, Stelmach, R, Vasquez, VS, Adcock, IM, Ahmed, H, Auffray, C, Bakke, P, Baribaud, F, Bel, EH, Bigler, J, Bisgaard, H, Boedigheimer, MJ, Bønnelykke, K, Brandsma, J, Brinkman, P, Bucchioni, E, Burg, D, Bush, A, Caruso, M, Chaiboonchoe, A, Chanez, P, Compton, CH, Corfield, J, D'Amico, A, Dahlén, B, Dahlén, SE, De Meulder, B, Djukanovic, R, Erpenbeck, VJ, Erzen, D, Fichtner, K, Fitch, N, Fleming, LJ, Formaggio, E, Fowler, SJ, Frey, U, Gahlemann, M, Geiser, T, Goss, V, Guo, Y-K, Hashimoto, S, Haughney, J, Hedlin, G, Hekking, PW, Higenbottam, T, Hohlfeld, JM, Holweg, C, Horváth, I, Howarth, P, James, AJ, Knowles, RG, Knox, AJ, Krug, N, Lefaudeux, D, Loza, MJ, Lutter, R, Manta, A, Masefield, S, Matthews, JG, Mazein, A, Meiser, A, Middelveld, RJM, Miralpeix, M, Montuschi, P, Mores, N, Murray, CS, Musial, J, Myles, D, Pahus, L, Pandis, I, Pavlidis, S, Postle, A, Powel, P, Praticò, G, Puig Valls, M, Rao, N, Roberts, A, Roberts, G, Rowe, A, Sandström, T, Schofield, JPR, Seibold, W, Selby, A, Shaw, DE, Sigmund, R, Singer, F, Skipp, PJ, Sousa, AR, Sterk, PJ, Sun, K, Thornton, B, van Aalderen, WM, van Geest, M, Vestbo, J, Vissing, NH, Wagener, AH, Wagers, SS, Weiszhart, Z, Wheelock, CE & Wilson, SJ 2019, 'Asthma similarities across ProAR (Brazil) and U-BIOPRED (Europe) adult cohorts of contrasting locations, ethnicity and socioeconomic status', Respiratory Medicine, vol. 161, 105817. https://doi.org/10.1016/j.rmed.2019.105817

TY - JOUR

T1 - Asthma similarities across ProAR (Brazil) and U-BIOPRED (Europe) adult cohorts of contrasting locations, ethnicity and socioeconomic status

AU - Cruz, A.A.

AU - Riley, J.H.

AU - Bansal, A.T.

AU - Ponte, E.V.

AU - Souza-Machado, A.

AU - Almeida, P.C.A.

AU - Biao-Lima, V.

AU - Davis, M.

AU - Bates, S.

AU - Adcock, I.M.

AU - Sterk, P.J.

AU - Chung, K.F.

AU - Alcantara-Neves, N.

AU - Almeida, P.C.A.

AU - Amorim, L.

AU - Araujo, M.I.

AU - Barnes, K.C.

AU - Barreto, M.L.

AU - Belitardo, E.

AU - Bião-Lima, V.

AU - Cardoso, L.

AU - Camargos, P.A.

AU - Chatkin, J.M.

AU - Costa, R.S.

AU - Coelho, A.C.C.

AU - Cooper, P.J.

AU - Cruz, A.A.

AU - Cruz, C.S.

AU - Cunha, J.

AU - de Jesus, J.V.

AU - Fernandes, J.

AU - Franco, R.A.

AU - Gomes-Filho, I.

AU - Lima-Matos, A.

AU - Figueiredo, C.A.

AU - Lessa, M.A.

AU - Lins, L.

AU - Mello, L.M.

AU - Moura-Santos, P.

AU - Muniz, I.S.

AU - Paixao-Araujo, I.

AU - Pinheiro, G.P.

AU - Ponte, E.V.

AU - Rodrigues, L.C.

AU - Santana, C.V.N.

AU - Santos-Lima, G.

AU - Souza, T.M.O.

AU - Souza-Machado, A.

AU - Souza-Machado, C.

AU - Stelmach, R.

AU - Vasquez, V.S.

AU - Adcock, I.M.

AU - Ahmed, H.

AU - Auffray, C.

AU - Bakke, P.

AU - Baribaud, F.

AU - Bel, E.H.

AU - Bigler, J.

AU - Bisgaard, H.

AU - Boedigheimer, M.J.

AU - Bønnelykke, K.

AU - Brandsma, J.

AU - Brinkman, P.

AU - Bucchioni, E.

AU - Burg, D.

AU - Bush, A.

AU - Caruso, M.

AU - Chaiboonchoe, A.

AU - Chanez, P.

AU - Compton, C.H.

AU - Corfield, J.

AU - D'Amico, A.

AU - Dahlén, B.

AU - Dahlén, S.E.

AU - De Meulder, B.

AU - Djukanovic, R.

AU - Erpenbeck, V.J.

AU - Erzen, D.

AU - Fichtner, K.

AU - Fitch, N.

AU - Fleming, L.J.

AU - Formaggio, E.

AU - Fowler, S.J.

AU - Frey, U.

AU - Gahlemann, M.

AU - Geiser, T.

AU - Goss, V.

AU - Guo, Y.-K.

AU - Hashimoto, S.

AU - Haughney, J.

AU - Hedlin, G.

AU - Hekking, P.W.

AU - Higenbottam, T.

AU - Hohlfeld, J.M.

AU - Holweg, C.

AU - Horváth, I.

AU - Howarth, P.

AU - James, A.J.

AU - Knowles, R.G.

AU - Knox, A.J.

AU - Krug, N.

AU - Lefaudeux, D.

AU - Loza, M.J.

AU - Lutter, R.

AU - Manta, A.

AU - Masefield, S.

AU - Matthews, J.G.

AU - Mazein, A.

AU - Meiser, A.

AU - Middelveld, R.J.M.

AU - Miralpeix, M.

AU - Montuschi, P.

AU - Mores, N.

AU - Murray, C.S.

AU - Musial, J.

AU - Myles, D.

AU - Pahus, L.

AU - Pandis, I.

AU - Pavlidis, S.

AU - Postle, A.

AU - Powel, P.

AU - Praticò, G.

AU - Puig Valls, M.

AU - Rao, N.

AU - Roberts, A.

AU - Roberts, G.

AU - Rowe, A.

AU - Sandström, T.

AU - Schofield, J.P.R.

AU - Seibold, W.

AU - Selby, A.

AU - Shaw, D.E.

AU - Sigmund, R.

AU - Singer, F.

AU - Skipp, P.J.

AU - Sousa, A.R.

AU - Sterk, P.J.

AU - Sun, K.

AU - Thornton, B.

AU - van Aalderen, W.M.

AU - van Geest, M.

AU - Vestbo, J.

AU - Vissing, N.H.

AU - Wagener, A.H.

AU - Wagers, S.S.

AU - Weiszhart, Z.

AU - Wheelock, C.E.

AU - Wilson, S.J.

N1 - Funding Information: For ProAR - Conselho Nacional de Desenvolvimento Científico e Tecnológico do Brasil (CNPq) – Grant # 471057/2014-2 , Fundação de Amparo a Pesquisa do Estado da Bahia (FAPESB) and GlaxoSmilthKline investigator initiated grant. For U-BIOPRED - IMI EU funded project (no. 115010 ). Publisher Copyright: © 2019 Copyright: Copyright 2019 Elsevier B.V., All rights reserved.

PY - 2019/11/25

Y1 - 2019/11/25

N2 - Background: Asthma prevalence is 339 million globally. ‘Severe asthma’ (SA) comprises subjects with uncontrolled asthma despite proper management. Objectives: To compare asthma from diverse ethnicities and environments. Methods: A cross-sectional analysis of two adult cohorts, a Brazilian (ProAR) and a European (U-BIOPRED). U-BIOPRED comprised of 311 non-smoking with Severe Asthma (SAn), 110 smokers or ex-smokers with SA (SAs) and 88 mild to moderate asthmatics (MMA) while ProAR included 544 SA and 452 MMA. Although these projects were independent, there were similarities in objectives and methodology, with ProAR adopting operating procedures of U-BIOPRED. Results: Among SA subjects, age, weight, proportion of former smokers and FEV 1 pre-bronchodilator were similar. The proportion of SA with a positive skin prick tests (SPT) to aeroallergens, the scores of sino-nasal symptoms and quality of life were comparable. In addition, blood eosinophil counts (EOS) and the % of subjects with EOS > 300 cells/μl were not different. The Europeans with SA however, were more severe with a greater proportion of continuous oral corticosteroids (OCS), worse symptoms and more frequent exacerbations. FEV 1/FVC pre- and post-bronchodilator were lower among the Europeans. The MMA cohorts were less comparable in control and treatment, but similar in the proportion of allergic rhinitis, gastroesophageal reflux disease and EOS >3%. Conclusions: ProAR and U-BIOPRED cohorts, with varying severity, ethnicity and environment have similarities, which provide the basis for global external validation of asthma phenotypes. This should stimulate collaboration between asthma consortia with the aim of understanding SA, which will lead to better management.

AB - Background: Asthma prevalence is 339 million globally. ‘Severe asthma’ (SA) comprises subjects with uncontrolled asthma despite proper management. Objectives: To compare asthma from diverse ethnicities and environments. Methods: A cross-sectional analysis of two adult cohorts, a Brazilian (ProAR) and a European (U-BIOPRED). U-BIOPRED comprised of 311 non-smoking with Severe Asthma (SAn), 110 smokers or ex-smokers with SA (SAs) and 88 mild to moderate asthmatics (MMA) while ProAR included 544 SA and 452 MMA. Although these projects were independent, there were similarities in objectives and methodology, with ProAR adopting operating procedures of U-BIOPRED. Results: Among SA subjects, age, weight, proportion of former smokers and FEV 1 pre-bronchodilator were similar. The proportion of SA with a positive skin prick tests (SPT) to aeroallergens, the scores of sino-nasal symptoms and quality of life were comparable. In addition, blood eosinophil counts (EOS) and the % of subjects with EOS > 300 cells/μl were not different. The Europeans with SA however, were more severe with a greater proportion of continuous oral corticosteroids (OCS), worse symptoms and more frequent exacerbations. FEV 1/FVC pre- and post-bronchodilator were lower among the Europeans. The MMA cohorts were less comparable in control and treatment, but similar in the proportion of allergic rhinitis, gastroesophageal reflux disease and EOS >3%. Conclusions: ProAR and U-BIOPRED cohorts, with varying severity, ethnicity and environment have similarities, which provide the basis for global external validation of asthma phenotypes. This should stimulate collaboration between asthma consortia with the aim of understanding SA, which will lead to better management.

KW - Asthma

KW - Biomarkers

KW - Cohort studies

KW - Cross sectional study

KW - Disease management

KW - Phenotypes

UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-85075530257&partnerID=MN8TOARS

U2 - 10.1016/j.rmed.2019.105817

DO - 10.1016/j.rmed.2019.105817

M3 - Article

SN - 0954-6111

VL - 161

JO - Respiratory Medicine

JF - Respiratory Medicine

M1 - 105817

ER -

Asthma similarities across ProAR (Brazil) and U-BIOPRED (Europe) adult cohorts of contrasting locations, ethnicity and socioeconomic status

Abstract

Keywords

UN SDGs

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