Astroglia in Alzheimer’s Disease

Alexei Verkhratsky, Vladimir Parpura, Jose Julio Rodriguez-Arellano, Robert Zorec

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Alzheimer’s disease is the most common cause of dementia. Cellular changes in the brains of the patients suffering from Alzheimer’s disease occur well in advance of the clinical symptoms. At the cellular level, the most dramatic is a demise of neurones. As astroglial cells carry out homeostatic functions of the brain, it is certain that these cells are at least in part a cause of Alzheimer’s disease. Historically, Alois Alzheimer himself has recognised this at the dawn of the disease description. However, the role of astroglia in this disease has been understudied. In this chapter, we summarise the various aspects of glial contribution to this disease and outline the potential of using these cells in prevention (exercise and environmental enrichment) and intervention of this devastating disease.

Original languageEnglish
Title of host publicationNeuroglia in Neurodegenerative Diseases
EditorsAlexei Verkhratsky, Margaret S. Ho, Robert Zorec, Vladimir Parpura
PublisherSpringer Nature
Chapter11
Pages273-324
Number of pages52
ISBN (Electronic)978-981-13-9913-8
ISBN (Print)978-981-13-9912-1
DOIs
Publication statusPublished - 1 Jan 2019

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1175
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Alzheimer’s disease
  • Astrocytes
  • Astroglial atrophy
  • Calcium signalling
  • Neurodegeneration
  • Pathological ageing
  • Stem cells

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