Astrogliopathology in neurological, neurodevelopmental and psychiatric disorders.

Alexei Verkhratsky, Vladimir Parpura

    Research output: Contribution to journalArticlepeer-review


    Astroglial cells represent a main element in the maintenance of homeostasis and providing defense to the brain. Consequently, their dysfunction underlies many, if not all, neurological, neurodevelopmental and neuropsychiatric disorders. General astrogliopathy is evident in diametrically opposing morpho-functional changes in astrocytes, i.e. their hypertrophy along with reactivity or atrophy with asthenia. Neurological disorders with astroglial participation can be genetic, of which Alexander disease is a primary sporadic astrogliopathy, environmentally caused, such as heavy metal encephalopathies, or neurodevelopmental in origin. Astroglia contribute to neurodegenerative processes seen in amyotrophic lateral sclerosis, Alzheimer's and Huntington's diseases. Furthermore, astroglia also play a role in major neuropsychiatric disorders, ranging from schizophrenia to depression, as well as in addictive disorders.
    Original languageEnglish
    JournalNeurobiology of disease
    Publication statusPublished - 3 Apr 2015


    • Astrocyte
    • Hepatic encephalopathy
    • Neurodegeneration
    • Neuroglia
    • Neurological diseases
    • Psychiatric diseases
    • Reactive astrogliosis


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