Abstract
Lithiation and silylation of N,N-dialkylmesitamides using chiral lithium amide bases leads to enantiomerically enriched atropisomeric amides (up to 89% ee) by desymmetrization of the enantiotopic Me groups. [on SciFinder (R)]
| Original language | English |
|---|---|
| Pages (from-to) | 371-375 |
| Journal | Journal of the Chemical Society, Perkin Transactions 1 |
| DOIs | |
| Publication status | Published - 2001 |
Keywords
- Asymmetric synthesis and induction (asym. synthesis of enantiomerically enriched atropisomeric amides by desymmetrization of N,N-dialkylmesitamides); Amides Role: SPN (Synthetic preparation), PREP (Preparation) (asym. synthesis of enantiomerically enriched atropisomeric amides by desymmetrization of N,N-dialkylmesitamides); Lithiation; Silylation (regioselective; asym. synthesis of enantiomerically enriched atropisomeric amides by desymmetrization of N,N-dialkylmesitamides)