Asymmetric synthesis of tertiary thiols and thioethers

Jonathan Clayden; Paul MacLellan

doi:10.3762/bjoc.7.68

Asymmetric synthesis of tertiary thiols and thioethers

Jonathan Clayden
, Paul MacLellan

Research output: Contribution to journal › Article › peer-review

Abstract

Enantiomerically pure tertiary thiols provide a major synthetic challenge, and despite the importance of chiral sulfur-containing compounds in biological and medicinal chemistry, surprisingly few effective methods are suitable for the asymmetric synthesis of tertiary thiols. This review details the most practical of the methods available. © 2011 Clayden and MacLellan; licensee Beilstein-Institut.

Original language	English
Article number	A68
Pages (from-to)	582-595
Number of pages	13
Journal	Beilstein Journal of Organic Chemistry
Volume	7
DOIs	https://doi.org/10.3762/bjoc.7.68
Publication status	Published - 10 May 2011

Keywords

Asymmetric synthesis
Organolithium
Substitution
Sulfur
Thiol

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10.3762/bjoc.7.68

http://www.beilstein-journals.org/bjoc/content/pdf/1860-5397-7-68.pdf

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AB - Enantiomerically pure tertiary thiols provide a major synthetic challenge, and despite the importance of chiral sulfur-containing compounds in biological and medicinal chemistry, surprisingly few effective methods are suitable for the asymmetric synthesis of tertiary thiols. This review details the most practical of the methods available. © 2011 Clayden and MacLellan; licensee Beilstein-Institut.

KW - Asymmetric synthesis

KW - Organolithium

KW - Substitution

KW - Sulfur

KW - Thiol

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DO - 10.3762/bjoc.7.68

M3 - Article

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JO - Beilstein Journal of Organic Chemistry

JF - Beilstein Journal of Organic Chemistry

M1 - A68

ER -

Asymmetric synthesis of tertiary thiols and thioethers

Abstract

Keywords

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