Asymmetric trehalose analogues to probe disaccharide processing pathways in mycobacteria

Hadyn L Parker; Ruben M F Tomás; Christopher M Furze; Collette S Guy; Elizabeth Fullam

doi:10.1039/d0ob00253d

Asymmetric trehalose analogues to probe disaccharide processing pathways in mycobacteria

Hadyn L Parker, Ruben M F Tomás, Christopher M Furze, Collette S Guy, Elizabeth Fullam

Chemical Biology and Biological Chemistry

The University of Warwick

Research output: Contribution to journal › Article › peer-review

Abstract

The uptake and metabolism of the disaccharide trehalose by Mycobacterium tuberculosis is essential for the virulence of this pathogen. Here we describe the chemoenzymatic synthesis of new azido-functionalised asymmetric trehalose probes that resist degradation by mycobacterial enzymes and are used to probe trehalose processing pathways in mycobacteria.

Original language	English
Pages (from-to)	3607-3612
Number of pages	6
Journal	Organic & biomolecular chemistry
Volume	18
Issue number	18
DOIs	https://doi.org/10.1039/d0ob00253d
Publication status	Published - 30 Apr 2020

Access to Document

10.1039/d0ob00253d

Cite this

@article{b130d9cef7ea42c3afc75beeab624b89,

title = "Asymmetric trehalose analogues to probe disaccharide processing pathways in mycobacteria",

abstract = "The uptake and metabolism of the disaccharide trehalose by Mycobacterium tuberculosis is essential for the virulence of this pathogen. Here we describe the chemoenzymatic synthesis of new azido-functionalised asymmetric trehalose probes that resist degradation by mycobacterial enzymes and are used to probe trehalose processing pathways in mycobacteria.",

author = "Parker, {Hadyn L} and Tom{\'a}s, {Ruben M F} and Furze, {Christopher M} and Guy, {Collette S} and Elizabeth Fullam",

year = "2020",

month = apr,

day = "30",

doi = "10.1039/d0ob00253d",

language = "English",

volume = "18",

pages = "3607--3612",

journal = "Organic & biomolecular chemistry",

issn = "1477-0520",

publisher = "Royal Society of Chemistry",

number = "18",

}

TY - JOUR

T1 - Asymmetric trehalose analogues to probe disaccharide processing pathways in mycobacteria

AU - Parker, Hadyn L

AU - Tomás, Ruben M F

AU - Furze, Christopher M

AU - Guy, Collette S

AU - Fullam, Elizabeth

PY - 2020/4/30

Y1 - 2020/4/30

N2 - The uptake and metabolism of the disaccharide trehalose by Mycobacterium tuberculosis is essential for the virulence of this pathogen. Here we describe the chemoenzymatic synthesis of new azido-functionalised asymmetric trehalose probes that resist degradation by mycobacterial enzymes and are used to probe trehalose processing pathways in mycobacteria.

AB - The uptake and metabolism of the disaccharide trehalose by Mycobacterium tuberculosis is essential for the virulence of this pathogen. Here we describe the chemoenzymatic synthesis of new azido-functionalised asymmetric trehalose probes that resist degradation by mycobacterial enzymes and are used to probe trehalose processing pathways in mycobacteria.

U2 - 10.1039/d0ob00253d

DO - 10.1039/d0ob00253d

M3 - Article

C2 - 32350493

SN - 1477-0520

VL - 18

SP - 3607

EP - 3612

JO - Organic & biomolecular chemistry

JF - Organic & biomolecular chemistry

IS - 18

ER -

Asymmetric trehalose analogues to probe disaccharide processing pathways in mycobacteria

Abstract

Access to Document

Fingerprint

Cite this