Asymmetric trehalose analogues to probe disaccharide processing pathways in mycobacteria

Hadyn L Parker; Ruben M F Tomás; Christopher M Furze; Collette S Guy; Elizabeth Fullam

doi:10.1039/d0ob00253d

Asymmetric trehalose analogues to probe disaccharide processing pathways in mycobacteria

Hadyn L Parker, Ruben M F Tomás, Christopher M Furze, Collette S Guy, Elizabeth Fullam

Chemical Biology and Biological Chemistry

The University of Warwick

Research output: Contribution to journal › Article › peer-review

Abstract

The uptake and metabolism of the disaccharide trehalose by Mycobacterium tuberculosis is essential for the virulence of this pathogen. Here we describe the chemoenzymatic synthesis of new azido-functionalised asymmetric trehalose probes that resist degradation by mycobacterial enzymes and are used to probe trehalose processing pathways in mycobacteria.

Original language	English
Pages (from-to)	3607-3612
Number of pages	6
Journal	Organic & biomolecular chemistry
Volume	18
Issue number	18
DOIs	https://doi.org/10.1039/d0ob00253d
Publication status	Published - 30 Apr 2020

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10.1039/d0ob00253d

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title = "Asymmetric trehalose analogues to probe disaccharide processing pathways in mycobacteria",

abstract = "The uptake and metabolism of the disaccharide trehalose by Mycobacterium tuberculosis is essential for the virulence of this pathogen. Here we describe the chemoenzymatic synthesis of new azido-functionalised asymmetric trehalose probes that resist degradation by mycobacterial enzymes and are used to probe trehalose processing pathways in mycobacteria.",

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AU - Parker, Hadyn L

AU - Tomás, Ruben M F

AU - Furze, Christopher M

AU - Guy, Collette S

AU - Fullam, Elizabeth

PY - 2020/4/30

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AB - The uptake and metabolism of the disaccharide trehalose by Mycobacterium tuberculosis is essential for the virulence of this pathogen. Here we describe the chemoenzymatic synthesis of new azido-functionalised asymmetric trehalose probes that resist degradation by mycobacterial enzymes and are used to probe trehalose processing pathways in mycobacteria.

U2 - 10.1039/d0ob00253d

DO - 10.1039/d0ob00253d

M3 - Article

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SP - 3607

EP - 3612

JO - Organic & biomolecular chemistry

JF - Organic & biomolecular chemistry

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Asymmetric trehalose analogues to probe disaccharide processing pathways in mycobacteria

Abstract

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