TY - GEN
T1 - Atlas-based quantification of myocardial motion abnormalities
T2 - 1st International Workshop on Statistical Atlases and Computational Models of the Heart, STACOM 2010 and Cardiac Electrophysiological Simulation Challenge, CESC 2010 - Held in Conjunction with MICCAI 2010
AU - Duchateau, Nicolas
AU - De Craene, Mathieu
AU - Piella, Gemma
AU - Hoogendoorn, Corné
AU - Silva, Etelvino
AU - Doltra, Adelina
AU - Mont, Lluís
AU - Castel, Ma Angeles
AU - Brugada, Josep
AU - Sitges, Marta
AU - Frangi, Alejandro F.
PY - 2010
Y1 - 2010
N2 - In this paper, we present the use of atlas-based indexes of abnormality for the quantification of cardiac resynchronization therapy (CRT) outcome in terms of motion. We build an atlas of normal motion from 21 healthy volunteers to which we compare 88 CRT candidates before and after the therapy. Abnormal motion is quantified locally in time and space using a statistical distance to normality, and changes induced by the therapy are related with clinical measurements of CRT outcome. Results correlate with recent clinical hypothesis about CRT response, namely that the correction of specific mechanisms responsible for cardiac dyssynchrony conditions the response to the therapy.
AB - In this paper, we present the use of atlas-based indexes of abnormality for the quantification of cardiac resynchronization therapy (CRT) outcome in terms of motion. We build an atlas of normal motion from 21 healthy volunteers to which we compare 88 CRT candidates before and after the therapy. Abnormal motion is quantified locally in time and space using a statistical distance to normality, and changes induced by the therapy are related with clinical measurements of CRT outcome. Results correlate with recent clinical hypothesis about CRT response, namely that the correction of specific mechanisms responsible for cardiac dyssynchrony conditions the response to the therapy.
UR - http://www.scopus.com/inward/record.url?scp=78049383725&partnerID=8YFLogxK
U2 - 10.1007/978-3-642-15835-3_7
DO - 10.1007/978-3-642-15835-3_7
M3 - Conference contribution
AN - SCOPUS:78049383725
SN - 364215834X
SN - 9783642158346
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 65
EP - 74
BT - Statistical Atlases and Computational Models of the Heart - First Int. Workshop, STACOM 2010 and Cardiac Electrophysiological Simulation Challenge, CESC 2010 - Held in Conj. with MICCAI 2010, Proc.
Y2 - 20 September 2010 through 20 September 2010
ER -