Atlas-based quantification of myocardial motion abnormalities: Added-value for the understanding of CRT outcome?

Nicolas Duchateau, Mathieu De Craene, Gemma Piella, Corné Hoogendoorn, Etelvino Silva, Adelina Doltra, Lluís Mont, Ma Angeles Castel, Josep Brugada, Marta Sitges, Alejandro F. Frangi

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

In this paper, we present the use of atlas-based indexes of abnormality for the quantification of cardiac resynchronization therapy (CRT) outcome in terms of motion. We build an atlas of normal motion from 21 healthy volunteers to which we compare 88 CRT candidates before and after the therapy. Abnormal motion is quantified locally in time and space using a statistical distance to normality, and changes induced by the therapy are related with clinical measurements of CRT outcome. Results correlate with recent clinical hypothesis about CRT response, namely that the correction of specific mechanisms responsible for cardiac dyssynchrony conditions the response to the therapy.

Original languageEnglish
Title of host publicationStatistical Atlases and Computational Models of the Heart - First Int. Workshop, STACOM 2010 and Cardiac Electrophysiological Simulation Challenge, CESC 2010 - Held in Conj. with MICCAI 2010, Proc.
Pages65-74
Number of pages10
DOIs
Publication statusPublished - 2010
Event1st International Workshop on Statistical Atlases and Computational Models of the Heart, STACOM 2010 and Cardiac Electrophysiological Simulation Challenge, CESC 2010 - Held in Conjunction with MICCAI 2010 - Beijing, China
Duration: 20 Sept 201020 Sept 2010

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume6364 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference1st International Workshop on Statistical Atlases and Computational Models of the Heart, STACOM 2010 and Cardiac Electrophysiological Simulation Challenge, CESC 2010 - Held in Conjunction with MICCAI 2010
Country/TerritoryChina
CityBeijing
Period20/09/1020/09/10

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