Abstract
The com. available ruthenium carbene complex RuCl2(:CHPh)(PCy3)2 efficiently catalyzes the cyclization of halo alkenes, e.g. Cl3CCO2CH2CH:CH2, to g-lactones and g-lactams, e.g. 3,3-dichloro-4-(chloromethyl)dihydro-2(3H)-furanone. [on SciFinder (R)]
| Original language | English |
|---|---|
| Pages (from-to) | 1797-1800 |
| Journal | SYNLETT |
| DOIs | |
| Publication status | Published - 2003 |
Keywords
- Alkenes Role: RCT (Reactant), RACT (Reactant or reagent) (halo; prepn. of g-lactones and g-lactams via atom transfer radical cyclizations of halo alkenes mediated by the Grubbs ruthenium metathesis catalyst); Cyclization; Cyclization catalysts (prepn. of g-lactones and g-lactams via atom transfer radical cyclizations of halo alkenes mediated by the Grubbs ruthenium metathesis catalyst); Lactones Role: SPN (Synthetic preparation), PREP (Preparation) (g-; prepn. of g-lactones and g-lactams via atom transfer radical cyclizations of halo alkenes mediated by the Grubbs ruthenium metathesis catalyst); Lactams Role: SPN (Synthetic preparation), PREP (Preparation) (g-lactams; prepn. of g-lactones and g-lactams via atom transfer radical cyclizations of halo alkenes mediated by the Grubbs ruthenium metathesis catalyst)