Attainment of Metabolic Goals in the Integrated UK Islet Transplant Program With Locally Isolated and Transported Preparations

A M Brooks; N Walker; A Aldibbiat; S Hughes; G Jones; J de Havilland; P Choudhary; G C Huang; N Parrott; N W McGowan; J Casey; L Mumford; P Barker; K Burling; R Hovorka; M Walker; R M Smith; S Forbes; M K Rutter; S Amiel; M J Rosenthal; P Johnson; J A Shaw

doi:10.1111/ajt.12469

Attainment of Metabolic Goals in the Integrated UK Islet Transplant Program With Locally Isolated and Transported Preparations

A M Brooks, N Walker, A Aldibbiat, S Hughes, G Jones, J de Havilland, P Choudhary, G C Huang, N Parrott, N W McGowan, J Casey, L Mumford, P Barker, K Burling, R Hovorka, M Walker, R M Smith, S Forbes, M K Rutter, S AmielM J Rosenthal, P Johnson, J A Shaw

Research output: Contribution to journal › Article › peer-review

Abstract

The objective was to determine whether metabolic goals have been achieved with locally isolated and transported preparations over the first 3 years of the UK's nationally funded integrated islet transplant program. Twenty islet recipients with C-peptide negative type 1 diabetes and recurrent severe hypoglycemia consented to the study, including standardized meal tolerance tests. Participants received a total of 35 infusions (seven recipients: single graft; 11 recipients: two grafts: two recipients: three grafts). Graft function was maintained in 80% at [median (interquartile range)] 24 (13.5-36) months postfirst transplant. Severe hypoglycemia was reduced from 20 (7-50) episodes/patient-year pretransplant to 0.3 (0-1.6) episodes/patient-year posttransplant (p <0.001). Resolution of impaired hypoglycemia awareness was confirmed [pretransplant: Gold score 6 (5-7); 24 (13.5-36) months: 3 (1.5-4.5); p <0.03]. Target HbA1c of

Original language	English
Journal	Am J Transplant
DOIs	https://doi.org/10.1111/ajt.12469
Publication status	Published - 2013

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Brooks, A. M., Walker, N., Aldibbiat, A., Hughes, S., Jones, G., de Havilland, J., Choudhary, P., Huang, G. C., Parrott, N., McGowan, N. W., Casey, J., Mumford, L., Barker, P., Burling, K., Hovorka, R., Walker, M., Smith, R. M., Forbes, S., Rutter, M. K., ... Shaw, J. A. (2013). Attainment of Metabolic Goals in the Integrated UK Islet Transplant Program With Locally Isolated and Transported Preparations. Am J Transplant. https://doi.org/10.1111/ajt.12469

@article{b7aae5e40e7243499527b02f9539ca9e,

title = "Attainment of Metabolic Goals in the Integrated UK Islet Transplant Program With Locally Isolated and Transported Preparations",

abstract = "The objective was to determine whether metabolic goals have been achieved with locally isolated and transported preparations over the first 3 years of the UK's nationally funded integrated islet transplant program. Twenty islet recipients with C-peptide negative type 1 diabetes and recurrent severe hypoglycemia consented to the study, including standardized meal tolerance tests. Participants received a total of 35 infusions (seven recipients: single graft; 11 recipients: two grafts: two recipients: three grafts). Graft function was maintained in 80% at [median (interquartile range)] 24 (13.5-36) months postfirst transplant. Severe hypoglycemia was reduced from 20 (7-50) episodes/patient-year pretransplant to 0.3 (0-1.6) episodes/patient-year posttransplant (p <0.001). Resolution of impaired hypoglycemia awareness was confirmed [pretransplant: Gold score 6 (5-7); 24 (13.5-36) months: 3 (1.5-4.5); p <0.03]. Target HbA1c of",

author = "Brooks, {A M} and N Walker and A Aldibbiat and S Hughes and G Jones and {de Havilland}, J and P Choudhary and Huang, {G C} and N Parrott and McGowan, {N W} and J Casey and L Mumford and P Barker and K Burling and R Hovorka and M Walker and Smith, {R M} and S Forbes and Rutter, {M K} and S Amiel and Rosenthal, {M J} and P Johnson and Shaw, {J A}",

note = "Brooks, A M Walker, N Aldibbiat, A Hughes, S Jones, G de Havilland, J Choudhary, P Huang, G C Parrott, N McGowan, N W A Casey, J Mumford, L Barker, P Burling, K Hovorka, R Walker, M Smith, R M Forbes, S Rutter, M K Amiel, S Rosenthal, M J Johnson, P Shaw, J A M Am J Transplant. 2013 Oct 1. doi: 10.1111/ajt.12469.",

year = "2013",

doi = "10.1111/ajt.12469",

language = "English",

journal = "Am J Transplant",

issn = "1600-6143",

publisher = "Elsevier BV",

}

Brooks, AM, Walker, N, Aldibbiat, A, Hughes, S, Jones, G, de Havilland, J, Choudhary, P, Huang, GC, Parrott, N, McGowan, NW, Casey, J, Mumford, L, Barker, P, Burling, K, Hovorka, R, Walker, M, Smith, RM, Forbes, S, Rutter, MK, Amiel, S, Rosenthal, MJ, Johnson, P & Shaw, JA 2013, 'Attainment of Metabolic Goals in the Integrated UK Islet Transplant Program With Locally Isolated and Transported Preparations', Am J Transplant. https://doi.org/10.1111/ajt.12469

TY - JOUR

T1 - Attainment of Metabolic Goals in the Integrated UK Islet Transplant Program With Locally Isolated and Transported Preparations

AU - Brooks, A M

AU - Walker, N

AU - Aldibbiat, A

AU - Hughes, S

AU - Jones, G

AU - de Havilland, J

AU - Choudhary, P

AU - Huang, G C

AU - Parrott, N

AU - McGowan, N W

AU - Casey, J

AU - Mumford, L

AU - Barker, P

AU - Burling, K

AU - Hovorka, R

AU - Walker, M

AU - Smith, R M

AU - Forbes, S

AU - Rutter, M K

AU - Amiel, S

AU - Rosenthal, M J

AU - Johnson, P

AU - Shaw, J A

N1 - Brooks, A M Walker, N Aldibbiat, A Hughes, S Jones, G de Havilland, J Choudhary, P Huang, G C Parrott, N McGowan, N W A Casey, J Mumford, L Barker, P Burling, K Hovorka, R Walker, M Smith, R M Forbes, S Rutter, M K Amiel, S Rosenthal, M J Johnson, P Shaw, J A M Am J Transplant. 2013 Oct 1. doi: 10.1111/ajt.12469.

PY - 2013

Y1 - 2013

N2 - The objective was to determine whether metabolic goals have been achieved with locally isolated and transported preparations over the first 3 years of the UK's nationally funded integrated islet transplant program. Twenty islet recipients with C-peptide negative type 1 diabetes and recurrent severe hypoglycemia consented to the study, including standardized meal tolerance tests. Participants received a total of 35 infusions (seven recipients: single graft; 11 recipients: two grafts: two recipients: three grafts). Graft function was maintained in 80% at [median (interquartile range)] 24 (13.5-36) months postfirst transplant. Severe hypoglycemia was reduced from 20 (7-50) episodes/patient-year pretransplant to 0.3 (0-1.6) episodes/patient-year posttransplant (p <0.001). Resolution of impaired hypoglycemia awareness was confirmed [pretransplant: Gold score 6 (5-7); 24 (13.5-36) months: 3 (1.5-4.5); p <0.03]. Target HbA1c of

AB - The objective was to determine whether metabolic goals have been achieved with locally isolated and transported preparations over the first 3 years of the UK's nationally funded integrated islet transplant program. Twenty islet recipients with C-peptide negative type 1 diabetes and recurrent severe hypoglycemia consented to the study, including standardized meal tolerance tests. Participants received a total of 35 infusions (seven recipients: single graft; 11 recipients: two grafts: two recipients: three grafts). Graft function was maintained in 80% at [median (interquartile range)] 24 (13.5-36) months postfirst transplant. Severe hypoglycemia was reduced from 20 (7-50) episodes/patient-year pretransplant to 0.3 (0-1.6) episodes/patient-year posttransplant (p <0.001). Resolution of impaired hypoglycemia awareness was confirmed [pretransplant: Gold score 6 (5-7); 24 (13.5-36) months: 3 (1.5-4.5); p <0.03]. Target HbA1c of

U2 - 10.1111/ajt.12469

DO - 10.1111/ajt.12469

M3 - Article

SN - 1600-6143

JO - Am J Transplant

JF - Am J Transplant

ER -

Attainment of Metabolic Goals in the Integrated UK Islet Transplant Program With Locally Isolated and Transported Preparations

Abstract

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