Attenuation of Forkhead signaling by the retinal determination factor DACH1

Jie Zhou; Chenguang Wang; Zhibin Wang; Will Dampier; Kongming Wu; Mathew C. Casimiro; Iouri Chepelev; Vladimir M. Popov; Andrew Quong; Aydin Tozeren; Keji Zhao; Michael P. Lisanti; Richard G. Pestell

doi:10.1073/pnas.1002746107

Attenuation of Forkhead signaling by the retinal determination factor DACH1

Jie Zhou, Chenguang Wang, Zhibin Wang, Will Dampier, Kongming Wu, Mathew C. Casimiro, Iouri Chepelev, Vladimir M. Popov, Andrew Quong, Aydin Tozeren, Keji Zhao, Michael P. Lisanti, Richard G. Pestell

Research output: Contribution to journal › Article › peer-review

Abstract

The Drosophila Dachshund (Dac) gene, cloned as a dominant inhibitor of the hyperactive growth factor mutant ellipse, encodes a key component of the retinal determination gene network that governs cell fate. Herein, cyclic amplification and selection of targets identified a DACH1 DNA-binding sequence that resembles the FOX (Forkhead box-containing protein) binding site. Genome-wide in silico promoter analysis of DACH1 binding sites identified gene clusters populating cellular pathways associated with the cell cycle and growth factor signaling. ChIP coupled with high-throughput sequencing mapped DACH1 binding sites to corresponding gene clusters predicted in silico and identified as weight matrix resembling the cyclic amplification and selection of targets-defined sequence. DACH1 antagonized FOXM1 target gene expression, promoter occupancy in the context of local chromatin, and contactindependent growth. Attenuation of FOX function by the cell fate determination pathway has broad implications given the diverse role of FOX proteins in cellular biology and tumorigenesis.

Original language	English
Pages (from-to)	6864-6869
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	107
Issue number	15
DOIs	https://doi.org/10.1073/pnas.1002746107
Publication status	Published - 13 Apr 2010

Keywords

Cell fate determination
Dachshund homolog 1
Forkhead protein
Transcription factor
Tumor suppressor

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1073/pnas.1002746107

http://www.pnas.org/content/107/15/6864.full.pdf

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Zhou, J., Wang, C., Wang, Z., Dampier, W., Wu, K., Casimiro, M. C., Chepelev, I., Popov, V. M., Quong, A., Tozeren, A., Zhao, K., Lisanti, M. P., & Pestell, R. G. (2010). Attenuation of Forkhead signaling by the retinal determination factor DACH1. Proceedings of the National Academy of Sciences of the United States of America, 107(15), 6864-6869. https://doi.org/10.1073/pnas.1002746107

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title = "Attenuation of Forkhead signaling by the retinal determination factor DACH1",

abstract = "The Drosophila Dachshund (Dac) gene, cloned as a dominant inhibitor of the hyperactive growth factor mutant ellipse, encodes a key component of the retinal determination gene network that governs cell fate. Herein, cyclic amplification and selection of targets identified a DACH1 DNA-binding sequence that resembles the FOX (Forkhead box-containing protein) binding site. Genome-wide in silico promoter analysis of DACH1 binding sites identified gene clusters populating cellular pathways associated with the cell cycle and growth factor signaling. ChIP coupled with high-throughput sequencing mapped DACH1 binding sites to corresponding gene clusters predicted in silico and identified as weight matrix resembling the cyclic amplification and selection of targets-defined sequence. DACH1 antagonized FOXM1 target gene expression, promoter occupancy in the context of local chromatin, and contactindependent growth. Attenuation of FOX function by the cell fate determination pathway has broad implications given the diverse role of FOX proteins in cellular biology and tumorigenesis.",

keywords = "Cell fate determination, Dachshund homolog 1, Forkhead protein, Transcription factor, Tumor suppressor",

author = "Jie Zhou and Chenguang Wang and Zhibin Wang and Will Dampier and Kongming Wu and Casimiro, {Mathew C.} and Iouri Chepelev and Popov, {Vladimir M.} and Andrew Quong and Aydin Tozeren and Keji Zhao and Lisanti, {Michael P.} and Pestell, {Richard G.}",

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doi = "10.1073/pnas.1002746107",

language = "English",

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Zhou, J, Wang, C, Wang, Z, Dampier, W, Wu, K, Casimiro, MC, Chepelev, I, Popov, VM, Quong, A, Tozeren, A, Zhao, K, Lisanti, MP & Pestell, RG 2010, 'Attenuation of Forkhead signaling by the retinal determination factor DACH1', Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 15, pp. 6864-6869. https://doi.org/10.1073/pnas.1002746107

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T1 - Attenuation of Forkhead signaling by the retinal determination factor DACH1

AU - Zhou, Jie

AU - Wang, Chenguang

AU - Wang, Zhibin

AU - Dampier, Will

AU - Wu, Kongming

AU - Casimiro, Mathew C.

AU - Chepelev, Iouri

AU - Popov, Vladimir M.

AU - Quong, Andrew

AU - Tozeren, Aydin

AU - Zhao, Keji

AU - Lisanti, Michael P.

AU - Pestell, Richard G.

N1 - 232240, PHS HHS, United StatesP30CA56036, NCI NIH HHS, United StatesR01AR055660, NIAMS NIH HHS, United StatesR01CA080250, NCI NIH HHS, United StatesR01CA098779, NCI NIH HHS, United StatesR01CA120876, NCI NIH HHS, United StatesR01CA70896, NCI NIH HHS, United StatesR01CA75503, NCI NIH HHS, United StatesR01CA86072, NCI NIH HHS, United States

PY - 2010/4/13

Y1 - 2010/4/13

N2 - The Drosophila Dachshund (Dac) gene, cloned as a dominant inhibitor of the hyperactive growth factor mutant ellipse, encodes a key component of the retinal determination gene network that governs cell fate. Herein, cyclic amplification and selection of targets identified a DACH1 DNA-binding sequence that resembles the FOX (Forkhead box-containing protein) binding site. Genome-wide in silico promoter analysis of DACH1 binding sites identified gene clusters populating cellular pathways associated with the cell cycle and growth factor signaling. ChIP coupled with high-throughput sequencing mapped DACH1 binding sites to corresponding gene clusters predicted in silico and identified as weight matrix resembling the cyclic amplification and selection of targets-defined sequence. DACH1 antagonized FOXM1 target gene expression, promoter occupancy in the context of local chromatin, and contactindependent growth. Attenuation of FOX function by the cell fate determination pathway has broad implications given the diverse role of FOX proteins in cellular biology and tumorigenesis.

AB - The Drosophila Dachshund (Dac) gene, cloned as a dominant inhibitor of the hyperactive growth factor mutant ellipse, encodes a key component of the retinal determination gene network that governs cell fate. Herein, cyclic amplification and selection of targets identified a DACH1 DNA-binding sequence that resembles the FOX (Forkhead box-containing protein) binding site. Genome-wide in silico promoter analysis of DACH1 binding sites identified gene clusters populating cellular pathways associated with the cell cycle and growth factor signaling. ChIP coupled with high-throughput sequencing mapped DACH1 binding sites to corresponding gene clusters predicted in silico and identified as weight matrix resembling the cyclic amplification and selection of targets-defined sequence. DACH1 antagonized FOXM1 target gene expression, promoter occupancy in the context of local chromatin, and contactindependent growth. Attenuation of FOX function by the cell fate determination pathway has broad implications given the diverse role of FOX proteins in cellular biology and tumorigenesis.

KW - Cell fate determination

KW - Dachshund homolog 1

KW - Forkhead protein

KW - Transcription factor

KW - Tumor suppressor

U2 - 10.1073/pnas.1002746107

DO - 10.1073/pnas.1002746107

M3 - Article

C2 - 20351289

SN - 0027-8424

VL - 107

SP - 6864

EP - 6869

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 15

ER -

Attenuation of Forkhead signaling by the retinal determination factor DACH1

Abstract

Keywords

UN SDGs

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