Attoliter Chemistry for Nano-Scale Functionalization of Graphene

Michael Hirtz, Sarah Varey, Harald Fuchs, Aravind Vijayaraghavan

    Research output: Contribution to journalArticlepeer-review


    The nanoscale, multiplexed functionalization of graphene in a device array is a critical step to realize graphene-based chemical and biosensors. We demonstrate that graphene can be functionalized with submicron resolution and in well-defined locations and patterns using reaction agents in attoliter quantities, utilizing dip-pen nanolithography or microchannel cantilever spotting. Specifically, we functionalize graphene with a biotin azide using click-chemistry and demonstrate the subsequent binding of fluorescently tagged streptavidin. The technique can be scaled up to multiplex functionalize graphene devices on a wafer-scale for sensor and biomedical applications.
    Original languageEnglish
    Pages (from-to)33371-33376
    Number of pages6
    JournalACS Applied Materials and Interfaces
    Early online date30 Nov 2016
    Publication statusPublished - 14 Dec 2016


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