Au-catalyzed cross-coupling of arenes via double Câ€“H activation

Xacobe Cambeiro; Nanna Ahlsten; Igor Larrosa

doi:10.1021/jacs.5b10593

Au-catalyzed cross-coupling of arenes via double Câ€“H activation

Xacobe Cambeiro, Nanna Ahlsten, Igor Larrosa

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Abstract

The first methodology for Au(I/III)-catalyzed oxidative cross-coupling of arenes via double Câ€“H activation has been developed. The reaction is fully selective for the cross-coupling between electron-rich hetero-/carbocyclic arenes and electron-poor arenes bearing relatively acidic Câ€“H bonds. The inherently high cross-selectivity of the system obviates the need for directing groups or a large excess of one of the coupling partners.

Original language	English
Journal	American Chemical Society. Journal
DOIs	https://doi.org/10.1021/jacs.5b10593
Publication status	Published - 8 Dec 2015

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CCDC 1424598: Experimental Crystal Structure Determination
Cambeiro, X. (Contributor), Ahlsten, N. (Contributor) & Larrosa, I. (Contributor), Cambridge Crystallographic Data Centre, 1 Jan 2016
DOI: 10.5517/cc1jtdsj, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc1jtdsj&sid=DataCite
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abstract = "The first methodology for Au(I/III)-catalyzed oxidative cross-coupling of arenes via double C{\^a}€“H activation has been developed. The reaction is fully selective for the cross-coupling between electron-rich hetero-/carbocyclic arenes and electron-poor arenes bearing relatively acidic C{\^a}€“H bonds. The inherently high cross-selectivity of the system obviates the need for directing groups or a large excess of one of the coupling partners.",

author = "Xacobe Cambeiro and Nanna Ahlsten and Igor Larrosa",

note = "We gratefully acknowledge the European Research Council for a Starting Grant (to I.L.) and the Marie Curie Foundation for Intra-European Fellowships (to X.C.C. and N.A.).",

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AU - Cambeiro, Xacobe

AU - Ahlsten, Nanna

AU - Larrosa, Igor

N1 - We gratefully acknowledge the European Research Council for a Starting Grant (to I.L.) and the Marie Curie Foundation for Intra-European Fellowships (to X.C.C. and N.A.).

PY - 2015/12/8

Y1 - 2015/12/8

N2 - The first methodology for Au(I/III)-catalyzed oxidative cross-coupling of arenes via double Câ€“H activation has been developed. The reaction is fully selective for the cross-coupling between electron-rich hetero-/carbocyclic arenes and electron-poor arenes bearing relatively acidic Câ€“H bonds. The inherently high cross-selectivity of the system obviates the need for directing groups or a large excess of one of the coupling partners.

AB - The first methodology for Au(I/III)-catalyzed oxidative cross-coupling of arenes via double Câ€“H activation has been developed. The reaction is fully selective for the cross-coupling between electron-rich hetero-/carbocyclic arenes and electron-poor arenes bearing relatively acidic Câ€“H bonds. The inherently high cross-selectivity of the system obviates the need for directing groups or a large excess of one of the coupling partners.

U2 - 10.1021/jacs.5b10593

DO - 10.1021/jacs.5b10593

M3 - Article

JO - American Chemical Society. Journal

JF - American Chemical Society. Journal

SN - 0002-7863

ER -

Au-catalyzed cross-coupling of arenes via double Câ€“H activation

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CCDC 1424598: Experimental Crystal Structure Determination

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