Augmentation of tendon healing with butyric acid-impregnated sutures: Biomechanical evaluation in a rabbit model

Bryan T. Leek; James P. Tasto; Lisa M. Tibor; Robert M. Healey; Anthony Freemont; Michael S. Linn; Derek E. Chase; David Amiel

doi:10.1177/0363546512450691

Augmentation of tendon healing with butyric acid-impregnated sutures: Biomechanical evaluation in a rabbit model

Bryan T. Leek, James P. Tasto, Lisa M. Tibor, Robert M. Healey, Anthony Freemont, Michael S. Linn, Derek E. Chase, David Amiel

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Butyric acid (BA) has been shown to be angiogenic and to enhance transcriptional activity in tissue. These properties of BA have the potential to augment biological healing of a repaired tendon. Purpose: To evaluate this possibility both biomechanically and histologically in an animal tendon repair model. Study Design: Controlled laboratory study. Methods: A rabbit Achilles tendon healing model was used to evaluate the biomechanical strength and histological properties at 6 and 12 weeks after repair. Unilateral tendon defects were created in the middle bundle of the Achilles tendon of each rabbit, which were repaired equivalently with either Ultrabraid BA-impregnated sutures or control Ultrabraid sutures. Results: After 6 weeks, BA-impregnated suture repairs had a significantly increased (P

Original language	English
Pages (from-to)	1762-1771
Number of pages	9
Journal	American Journal of Sports Medicine
Volume	40
Issue number	8
DOIs	https://doi.org/10.1177/0363546512450691
Publication status	Published - Aug 2012

Keywords

angiogenesis
butyric acid
suture material
tendon repair

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10.1177/0363546512450691

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title = "Augmentation of tendon healing with butyric acid-impregnated sutures: Biomechanical evaluation in a rabbit model",

abstract = "Background: Butyric acid (BA) has been shown to be angiogenic and to enhance transcriptional activity in tissue. These properties of BA have the potential to augment biological healing of a repaired tendon. Purpose: To evaluate this possibility both biomechanically and histologically in an animal tendon repair model. Study Design: Controlled laboratory study. Methods: A rabbit Achilles tendon healing model was used to evaluate the biomechanical strength and histological properties at 6 and 12 weeks after repair. Unilateral tendon defects were created in the middle bundle of the Achilles tendon of each rabbit, which were repaired equivalently with either Ultrabraid BA-impregnated sutures or control Ultrabraid sutures. Results: After 6 weeks, BA-impregnated suture repairs had a significantly increased (P",

keywords = "angiogenesis, butyric acid, suture material, tendon repair",

author = "Leek, {Bryan T.} and Tasto, {James P.} and Tibor, {Lisa M.} and Healey, {Robert M.} and Anthony Freemont and Linn, {Michael S.} and Chase, {Derek E.} and David Amiel",

year = "2012",

month = aug,

doi = "10.1177/0363546512450691",

language = "English",

volume = "40",

pages = "1762--1771",

journal = "American Journal of Sports Medicine",

issn = "1552-3365",

publisher = "Sage Publications Ltd",

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TY - JOUR

T1 - Augmentation of tendon healing with butyric acid-impregnated sutures: Biomechanical evaluation in a rabbit model

AU - Leek, Bryan T.

AU - Tasto, James P.

AU - Tibor, Lisa M.

AU - Healey, Robert M.

AU - Freemont, Anthony

AU - Linn, Michael S.

AU - Chase, Derek E.

AU - Amiel, David

PY - 2012/8

Y1 - 2012/8

N2 - Background: Butyric acid (BA) has been shown to be angiogenic and to enhance transcriptional activity in tissue. These properties of BA have the potential to augment biological healing of a repaired tendon. Purpose: To evaluate this possibility both biomechanically and histologically in an animal tendon repair model. Study Design: Controlled laboratory study. Methods: A rabbit Achilles tendon healing model was used to evaluate the biomechanical strength and histological properties at 6 and 12 weeks after repair. Unilateral tendon defects were created in the middle bundle of the Achilles tendon of each rabbit, which were repaired equivalently with either Ultrabraid BA-impregnated sutures or control Ultrabraid sutures. Results: After 6 weeks, BA-impregnated suture repairs had a significantly increased (P

AB - Background: Butyric acid (BA) has been shown to be angiogenic and to enhance transcriptional activity in tissue. These properties of BA have the potential to augment biological healing of a repaired tendon. Purpose: To evaluate this possibility both biomechanically and histologically in an animal tendon repair model. Study Design: Controlled laboratory study. Methods: A rabbit Achilles tendon healing model was used to evaluate the biomechanical strength and histological properties at 6 and 12 weeks after repair. Unilateral tendon defects were created in the middle bundle of the Achilles tendon of each rabbit, which were repaired equivalently with either Ultrabraid BA-impregnated sutures or control Ultrabraid sutures. Results: After 6 weeks, BA-impregnated suture repairs had a significantly increased (P

KW - angiogenesis

KW - butyric acid

KW - suture material

KW - tendon repair

U2 - 10.1177/0363546512450691

DO - 10.1177/0363546512450691

M3 - Article

C2 - 22729622

SN - 1552-3365

VL - 40

SP - 1762

EP - 1771

JO - American Journal of Sports Medicine

JF - American Journal of Sports Medicine

IS - 8

ER -

Augmentation of tendon healing with butyric acid-impregnated sutures: Biomechanical evaluation in a rabbit model

Abstract

Keywords

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