Aurora-kinase inhibitors as anticancer agents

Nicholas Keen; Stephen Taylor

doi:10.1038/nrc1502

Aurora-kinase inhibitors as anticancer agents

Research output: Contribution to journal › Article › peer-review

Abstract

Errors in mitosis can provide a source of the genomic instability that is typically associated with tumorigenesis. Many mitotic regulators are aberrantly expressed in tumour cells. These proteins could therefore make useful therapeutic targets. The kinases Aurora-A, -B and -C represent a family of such targets and several small-molecule inhibitors have been shown to block their function. Not only have these inhibitors advanced our understanding of mitosis, but, importantly, their in vivo antitumour activity has recently been reported. What have these studies taught us about the therapeutic potential of inhibiting this family of kinases?

Original language	English
Pages (from-to)	927-936
Number of pages	9
Journal	Nature Reviews Cancer
Volume	4
Issue number	12
DOIs	https://doi.org/10.1038/nrc1502
Publication status	Published - Dec 2004

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abstract = "Errors in mitosis can provide a source of the genomic instability that is typically associated with tumorigenesis. Many mitotic regulators are aberrantly expressed in tumour cells. These proteins could therefore make useful therapeutic targets. The kinases Aurora-A, -B and -C represent a family of such targets and several small-molecule inhibitors have been shown to block their function. Not only have these inhibitors advanced our understanding of mitosis, but, importantly, their in vivo antitumour activity has recently been reported. What have these studies taught us about the therapeutic potential of inhibiting this family of kinases?",

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Aurora-kinase inhibitors as anticancer agents

Abstract

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