Autism: In search of susceptibility genes

Janine A. Lamb; Jeremy R. Parr; Anthony J. Bailey; Anthony P. Monaco

doi:10.1385/NMM:2:1:11

Autism: In search of susceptibility genes

Janine A. Lamb, Jeremy R. Parr, Anthony J. Bailey, Anthony P. Monaco

Research output: Contribution to journal › Article › peer-review

Abstract

Autism is a neurodevelopmental disorder of unknown etiology. There is convincing data for the involvement of genetic factors in the development of autism, and the absence of any consistent evidence for an environmental, neuroanatomical, or biochemical cause has led to an increasing number of genetic studies to determine the basis of this complex disorder. The results of recent genetic linkage and candidate gene studies are reviewed in relation to the challenge of clinical and genetic heterogeneity, and prospects for the future of genetic research in autism are considered.

Original language	English
Pages (from-to)	11-28
Number of pages	17
Journal	Neuromolecular medicine
Volume	2
Issue number	1
DOIs	https://doi.org/10.1385/NMM:2:1:11
Publication status	Published - 2002

Keywords

Autism
Candidate gene
Chromosomal abnormality
Genetics
Heterogeneity
Language
Linkage
Pervasive developmental disorder

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10.1385/NMM:2:1:11

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abstract = "Autism is a neurodevelopmental disorder of unknown etiology. There is convincing data for the involvement of genetic factors in the development of autism, and the absence of any consistent evidence for an environmental, neuroanatomical, or biochemical cause has led to an increasing number of genetic studies to determine the basis of this complex disorder. The results of recent genetic linkage and candidate gene studies are reviewed in relation to the challenge of clinical and genetic heterogeneity, and prospects for the future of genetic research in autism are considered.",

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KW - Candidate gene

KW - Chromosomal abnormality

KW - Genetics

KW - Heterogeneity

KW - Language

KW - Linkage

KW - Pervasive developmental disorder

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Autism: In search of susceptibility genes

Abstract

Keywords

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