Autoimmunity in human primary immunodeficiency diseases

Peter D. Arkwright, Mario Abinun, Andrew J. Cant

    Research output: Contribution to journalArticlepeer-review


    Human primary immunodeficiency diseases are experiments of nature characterized by an increased susceptibility to infection. In many cases, they are also associated with troublesome and sometimes life-threatening autoimmune complications. In the past few years, great strides have been made in understanding the molecular basis of primary immunodeficiencies, and this had led to more focused and successful treatment. This review has 3 aims: (1) to highlight the variety of autoimmune phenomena associated with human primary immunodeficiency diseases; (2) to explore how primary immunodeficiencies predispose patients to autoimmune phenomena triggered by opportunistic infections; and (3) to consider the rationale for the current treatment strategies for autoimmune phenomena, specifically in relation to primary immunodeficiency diseases. Reviewing recent advances in our understanding of the small subgroup of patients with defined causes for their autoimmunity may lead to the development of more effective treatment strategies for idiopathic human autoimmune diseases. © 2002 by The American Society of Hematology.
    Original languageEnglish
    Pages (from-to)2694-2702
    Number of pages8
    Issue number8
    Publication statusPublished - 15 Apr 2002


    Dive into the research topics of 'Autoimmunity in human primary immunodeficiency diseases'. Together they form a unique fingerprint.

    Cite this