Autoradiographic analysis of [3H]kainic acid binding in primate brain.

A Cross, W Skan, P Slater, I Mitchell, AA.R. Crossman

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The distribution of [3H]kainic acid binding sites was studied in the primate brain using semiquantitative autoradiography. The highest levels of binding were observed in the hippocampal area CA3 and the dentate gyrus. The deep layers of pyriform, cingulate and insular cortex, the central nucleus of the amygdala and the caudate nucleus also displayed high levels of [3H]kainic acid binding. Although these areas receive putative excitatory amino acid-containing afferents, other regions containing a similar input displayed low levels of binding. Some similarities were apparent between the distribution of binding sites and pathological changes in human neurodegenerative disorders such as temporal lobe epilepsy.
    Original languageEnglish
    JournalJournal of Receptor Research
    Volume7( 6)
    Publication statusPublished - 1987

    Keywords

    • Animals
    • Autoradiography
    • metabolism: Basal Ganglia
    • Binding Sites
    • metabolism: Brain
    • metabolism: Brain Stem
    • metabolism: Cerebellum
    • metabolism: Cerebral Cortex
    • Haplorhini
    • metabolism: Hippocampus
    • metabolism: Kainic Acid
    • Male

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