AUTOTAXIN INHIBITORY COMPOUNDS

Lee Stockley, Martin; Catherine MacDonald, Ellen; Shah Pritom,; Allan Jordan,; James Hitchin,; Niall Hamilton,

AUTOTAXIN INHIBITORY COMPOUNDS

Lee Stockley, Martin (Inventor), Catherine MacDonald, Ellen (Inventor), Shah Pritom, (Inventor), Allan Jordan, (Inventor), James Hitchin, (Inventor), Niall Hamilton, (Inventor)

Cancer Research UK Manchester Institute

Cancer Research Technology Limited (t/a Cancer Research Horizons)

Research output: Patent

Abstract

The present invention relates to compounds of formula I, wherein A1, A2, A3, R1, R2, R3, R4, R5, R6, L, Ar and Q are each as defined herein. The compounds of the present invention are inhibitors of autotaxin (ATX) enzyme activity. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions (e.g. fibrosis) in which ATX activity is implicated.

Original language	English
Patent number	WO2016124939
IPC	A61P 35/ 00 A I
Priority date	6/02/15
Publication status	Published - 11 Aug 2016

Research Beacons, Institutes and Platforms

Manchester Cancer Research Centre

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "AUTOTAXIN INHIBITORY COMPOUNDS",

abstract = "The present invention relates to compounds of formula I, wherein A1, A2, A3, R1, R2, R3, R4, R5, R6, L, Ar and Q are each as defined herein. The compounds of the present invention are inhibitors of autotaxin (ATX) enzyme activity. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions (e.g. fibrosis) in which ATX activity is implicated.",

author = "{Stockley, Martin}, Lee and {MacDonald, Ellen}, Catherine and Shah Pritom, and Allan Jordan, and James Hitchin, and Niall Hamilton,",

year = "2016",

month = aug,

day = "11",

language = "English",

type = "Patent",

note = "WO2016124939; A61P 35/ 00 A I",

}

TY - PAT

T1 - AUTOTAXIN INHIBITORY COMPOUNDS

AU - Stockley, Martin, Lee

AU - MacDonald, Ellen, Catherine

AU - Pritom,, Shah

AU - Jordan,, Allan

AU - Hitchin,, James

AU - Hamilton,, Niall

PY - 2016/8/11

Y1 - 2016/8/11

N2 - The present invention relates to compounds of formula I, wherein A1, A2, A3, R1, R2, R3, R4, R5, R6, L, Ar and Q are each as defined herein. The compounds of the present invention are inhibitors of autotaxin (ATX) enzyme activity. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions (e.g. fibrosis) in which ATX activity is implicated.

AB - The present invention relates to compounds of formula I, wherein A1, A2, A3, R1, R2, R3, R4, R5, R6, L, Ar and Q are each as defined herein. The compounds of the present invention are inhibitors of autotaxin (ATX) enzyme activity. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions (e.g. fibrosis) in which ATX activity is implicated.

M3 - Patent

M1 - WO2016124939

ER -

AUTOTAXIN INHIBITORY COMPOUNDS

Abstract

Research Beacons, Institutes and Platforms

UN SDGs

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