B cell receptor expression level determines the fate of developing B lymphocytes: Receptor editing versus selection

Valerie Kouskoff, Georges Lacaud, Kathryn Pape, Marc Retter, David Nemazee

    Research output: Contribution to journalArticlepeer-review

    Abstract

    During B lymphocyte development, antibody genes are assembled by DNA recombination. Successful cell surface expression of IgM promotes developmental progression. However, when antigen receptors bind autoantigen, development is blocked and ongoing antibody gene recombination occurs, which often alters antibody specificity in a process called receptor editing. We demonstrate here a significant role of developmental block and receptor editing in B cell receptor quality control. During development a functional, non-self-reactive receptor undergoes receptor editing if its expression is below a certain threshold. Doubling the receptor gene dose promotes development in the absence of autoantigen, but allows editing when autoantigen is present. Thus, both underexpressed and harmful B cell receptors can undergo correction by receptor editing.
    Original languageEnglish
    Pages (from-to)7435-7439
    Number of pages5
    JournalProceedings of the National Academy of Sciences of the United States of America
    Volume97
    Issue number13
    DOIs
    Publication statusPublished - 20 Jun 2000

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