Back to basics - How the evolution of the extracellular matrix underpinned vertebrate evolution

Julie Huxley-Jones, John W. Pinney, John Archer, David L. Robertson, Raymond P. Boot-Handford

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The extracellular matrix (ECM) is a complex substrate that is involved in and influences a spectrum of behaviours such as growth and differentiation and is the basis for the structure of tissues. Although a characteristic of all metazoans, the ECM has elaborated into a variety of tissues unique to vertebrates, such as bone, tendon and cartilage. Here we review recent advances in our understanding of the molecular evolution of the ECM. Furthermore, we demonstrate that ECM genes represent a pivotal family of proteins the evolution of which appears to have played an important role in the evolution of vertebrates. © 2009 Blackwell Publishing Ltd.
    Original languageEnglish
    Pages (from-to)95-100
    Number of pages5
    JournalInternational Journal of Experimental Pathology
    Volume90
    Issue number2
    DOIs
    Publication statusPublished - Apr 2009

    Keywords

    • Duplication
    • Evolution
    • Extracellular matrix
    • Genome
    • Vertebrate

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