Baclofen is a potent activator of brown fat metabolism

N. J. Rothwell; J. I. Addae; M. J. Stock; T. W. Stone

Baclofen is a potent activator of brown fat metabolism

N. J. Rothwell, J. I. Addae, M. J. Stock, T. W. Stone

Office of the President & Vice Chancellor

Research output: Contribution to journal › Article › peer-review

Abstract

The injection of (±)-baclofen intravenously or directly into the ventromedial hypothalamus of urethane-anaesthetized rats, produced an activation of brown fat metabolism. This was seen as an increase of brown fat and rectal temperatures, and an increase of GDP binding in brown fat mitochondria. The activation was mediated by the sympathetic supply.

Original language	English
Pages (from-to)	926-927
Number of pages	1
Journal	Journal of Pharmacy and Pharmacology
Volume	37
Issue number	12
Publication status	Published - 1985

Cite this

@article{61b4049fa8f848888d0dd59c3c8086cd,

title = "Baclofen is a potent activator of brown fat metabolism",

abstract = "The injection of (±)-baclofen intravenously or directly into the ventromedial hypothalamus of urethane-anaesthetized rats, produced an activation of brown fat metabolism. This was seen as an increase of brown fat and rectal temperatures, and an increase of GDP binding in brown fat mitochondria. The activation was mediated by the sympathetic supply.",

author = "Rothwell, {N. J.} and Addae, {J. I.} and Stock, {M. J.} and Stone, {T. W.}",

year = "1985",

language = "English",

volume = "37",

pages = "926--927",

journal = "Journal of Pharmacy and Pharmacology",

issn = "2042-7158",

publisher = "Oxford University Press",

number = "12",

}

TY - JOUR

T1 - Baclofen is a potent activator of brown fat metabolism

AU - Rothwell, N. J.

AU - Addae, J. I.

AU - Stock, M. J.

AU - Stone, T. W.

PY - 1985

Y1 - 1985

N2 - The injection of (±)-baclofen intravenously or directly into the ventromedial hypothalamus of urethane-anaesthetized rats, produced an activation of brown fat metabolism. This was seen as an increase of brown fat and rectal temperatures, and an increase of GDP binding in brown fat mitochondria. The activation was mediated by the sympathetic supply.

AB - The injection of (±)-baclofen intravenously or directly into the ventromedial hypothalamus of urethane-anaesthetized rats, produced an activation of brown fat metabolism. This was seen as an increase of brown fat and rectal temperatures, and an increase of GDP binding in brown fat mitochondria. The activation was mediated by the sympathetic supply.

M3 - Article

SN - 2042-7158

VL - 37

SP - 926

EP - 927

JO - Journal of Pharmacy and Pharmacology

JF - Journal of Pharmacy and Pharmacology

IS - 12

ER -

Baclofen is a potent activator of brown fat metabolism

Abstract

Fingerprint

Cite this