Bacteriophage deficiency characterizes respiratory virome dysbiosis in childhood asthma

Spyridon Megremis, Bede Constantinides, Paraskevi Xepapadaki, David Robertson, Nikolaos Papadopoulos, Avraam Tapinos

Research output: Contribution to journalArticle


Asthma development and persistence is tightly linked to respiratory viruses. Viral presence is usually interrogated with targeted approaches during periods of disease activity and/or infections, thus neglecting viral occurrence during steady states. We investigate the virome in the upper respiratory system of healthy and asthmatic preschool children during asymptomatic/non-infection periods using metagenomics. Children with asthma have a characteristically dysbiotic virome that correlates to disease severity and control. The major component of dysbiosis is bacteriophage deficiency, while eukaryotic viral presence is increased. At the metacommunity level, differential virus species co-occurrence patterns suggest a decrease of the microbiota community resilience in asthma. Viral dysbiosis is therefore a key characteristic of asthma pathophysiology.
Original languageEnglish
Publication statusPublished - 4 Aug 2020

Research Beacons, Institutes and Platforms

  • Lydia Becker Institute


Dive into the research topics of 'Bacteriophage deficiency characterizes respiratory virome dysbiosis in childhood asthma'. Together they form a unique fingerprint.

Cite this