BAG-1: A multi-functional pro-survival molecule

Paul A. Townsend, Anastasis Stephanou, Graham Packham, David S. Latchman

    Research output: Contribution to journalArticlepeer-review

    Abstract

    BAG-1 is a multi-functional protein that exists as three functionally distinct and differentially localized isoforms which originate from a single mRNA and interact with a wide range of cellular targets. These include heat shock proteins, nuclear hormone receptors, signalling molecules, the anti-apoptotic BCL-2 protein and components of the ubiquitylation/proteasome machinery. Overexpression of BAG-1 isoforms has been demonstrated to regulate apoptosis, proliferation, transcription, metastasis and cell motility in a wide variety of cell systems. Since BAG-1 has a role in many biological pathways there is increasing evidence supporting the view that BAG-1 is an important molecule in disease, for example, potentially modulating both cell survival and response to nuclear hormones in breast cancer, and BAG-1 is a potential molecular target for therapeutic intervention. © 2004 Elsevier Ltd. All rights reserved.
    Original languageEnglish
    Pages (from-to)251-259
    Number of pages8
    JournalInternational Journal of Biochemistry and Cell Biology
    Volume37
    Issue number2
    DOIs
    Publication statusPublished - Feb 2005

    Keywords

    • Apoptosis
    • BAG-1
    • Cancer
    • HSC70
    • HSP70
    • Proteasome
    • Ubiquitin

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