BAG-1: A multi-functional pro-survival molecule

Paul A. Townsend; Anastasis Stephanou; Graham Packham; David S. Latchman

doi:10.1016/j.biocel.2004.03.016

BAG-1: A multi-functional pro-survival molecule

Paul A. Townsend, Anastasis Stephanou, Graham Packham, David S. Latchman

Research output: Contribution to journal › Article › peer-review

Abstract

BAG-1 is a multi-functional protein that exists as three functionally distinct and differentially localized isoforms which originate from a single mRNA and interact with a wide range of cellular targets. These include heat shock proteins, nuclear hormone receptors, signalling molecules, the anti-apoptotic BCL-2 protein and components of the ubiquitylation/proteasome machinery. Overexpression of BAG-1 isoforms has been demonstrated to regulate apoptosis, proliferation, transcription, metastasis and cell motility in a wide variety of cell systems. Since BAG-1 has a role in many biological pathways there is increasing evidence supporting the view that BAG-1 is an important molecule in disease, for example, potentially modulating both cell survival and response to nuclear hormones in breast cancer, and BAG-1 is a potential molecular target for therapeutic intervention. © 2004 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	251-259
Number of pages	8
Journal	International Journal of Biochemistry and Cell Biology
Volume	37
Issue number	2
DOIs	https://doi.org/10.1016/j.biocel.2004.03.016
Publication status	Published - Feb 2005

Keywords

Apoptosis
BAG-1
Cancer
HSC70
HSP70
Proteasome
Ubiquitin

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.biocel.2004.03.016

Cite this

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title = "BAG-1: A multi-functional pro-survival molecule",

abstract = "BAG-1 is a multi-functional protein that exists as three functionally distinct and differentially localized isoforms which originate from a single mRNA and interact with a wide range of cellular targets. These include heat shock proteins, nuclear hormone receptors, signalling molecules, the anti-apoptotic BCL-2 protein and components of the ubiquitylation/proteasome machinery. Overexpression of BAG-1 isoforms has been demonstrated to regulate apoptosis, proliferation, transcription, metastasis and cell motility in a wide variety of cell systems. Since BAG-1 has a role in many biological pathways there is increasing evidence supporting the view that BAG-1 is an important molecule in disease, for example, potentially modulating both cell survival and response to nuclear hormones in breast cancer, and BAG-1 is a potential molecular target for therapeutic intervention. {\textcopyright} 2004 Elsevier Ltd. All rights reserved.",

keywords = "Apoptosis, BAG-1, Cancer, HSC70, HSP70, Proteasome, Ubiquitin",

author = "Townsend, {Paul A.} and Anastasis Stephanou and Graham Packham and Latchman, {David S.}",

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doi = "10.1016/j.biocel.2004.03.016",

language = "English",

volume = "37",

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journal = "International Journal of Biochemistry and Cell Biology",

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}

TY - JOUR

T1 - BAG-1: A multi-functional pro-survival molecule

AU - Townsend, Paul A.

AU - Stephanou, Anastasis

AU - Packham, Graham

AU - Latchman, David S.

PY - 2005/2

Y1 - 2005/2

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AB - BAG-1 is a multi-functional protein that exists as three functionally distinct and differentially localized isoforms which originate from a single mRNA and interact with a wide range of cellular targets. These include heat shock proteins, nuclear hormone receptors, signalling molecules, the anti-apoptotic BCL-2 protein and components of the ubiquitylation/proteasome machinery. Overexpression of BAG-1 isoforms has been demonstrated to regulate apoptosis, proliferation, transcription, metastasis and cell motility in a wide variety of cell systems. Since BAG-1 has a role in many biological pathways there is increasing evidence supporting the view that BAG-1 is an important molecule in disease, for example, potentially modulating both cell survival and response to nuclear hormones in breast cancer, and BAG-1 is a potential molecular target for therapeutic intervention. © 2004 Elsevier Ltd. All rights reserved.

KW - Apoptosis

KW - BAG-1

KW - Cancer

KW - HSC70

KW - HSP70

KW - Proteasome

KW - Ubiquitin

U2 - 10.1016/j.biocel.2004.03.016

DO - 10.1016/j.biocel.2004.03.016

M3 - Article

C2 - 15474970

VL - 37

SP - 251

EP - 259

JO - International Journal of Biochemistry and Cell Biology

JF - International Journal of Biochemistry and Cell Biology

SN - 1357-2725

IS - 2

ER -

BAG-1: A multi-functional pro-survival molecule

Abstract

Keywords

UN SDGs

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