Baicalein maintains redox balance in experimental hyperlipidemic rats

S.S. Tripathi; R. Kumar; A. Bissoyi; S.I. Rizvi

doi:10.1080/13813455.2020.1760890

Baicalein maintains redox balance in experimental hyperlipidemic rats

S.S. Tripathi
, R. Kumar
, A. Bissoyi
, S.I. Rizvi

Chemical Biology and Biological Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Context: An altered lipid profile may lead to the development of CVD.

Objective: We evaluated the protective role of baicalein (BAC) against lipidemic and oxidative stress in hyperlipidemic challenged Wistar rats.

Materials and methods: Male Wistar rats were given a high-fat diet (HFD) (suspension (w/v) of 0.5% cholesterol, 3% coconut oil and 0.25% cholic acid for 30 days) to create a hyperlipidemic model. BAC was supplemented to experimental rats (80 mg/kg body weight). Biomarkers of oxidative stress including ROS, FRAP, GSH, PMRS, AGE, MDA, PCO, AOPP, and other parameters (Paraoxonase-1, SGOT, SGPT) including TNF-α and IL-6, were estimated in blood.

Results: Oxidative stress and inflammatory markers were significantly increased in the HFD treated group. BAC treatment protected rats from HFD mediated alterations.

Discussion & conclusion: Our results indicate that baicalein provides protection against hyperlipidemic stress and redox imbalance induced by HFD in rats.

Original language	English
Pages (from-to)	1156-1164
Number of pages	9
Journal	Archives of Physiology and Biochemistry
Volume	128
DOIs	https://doi.org/10.1080/13813455.2020.1760890
Publication status	Published - 12 May 2020

Keywords

Hyperlipidaemia
baicalein
oxidative stress
blood
liver
rat

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10.1080/13813455.2020.1760890

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title = "Baicalein maintains redox balance in experimental hyperlipidemic rats",

abstract = "Context: An altered lipid profile may lead to the development of CVD. Objective: We evaluated the protective role of baicalein (BAC) against lipidemic and oxidative stress in hyperlipidemic challenged Wistar rats. Materials and methods: Male Wistar rats were given a high-fat diet (HFD) (suspension (w/v) of 0.5\% cholesterol, 3\% coconut oil and 0.25\% cholic acid for 30 days) to create a hyperlipidemic model. BAC was supplemented to experimental rats (80 mg/kg body weight). Biomarkers of oxidative stress including ROS, FRAP, GSH, PMRS, AGE, MDA, PCO, AOPP, and other parameters (Paraoxonase-1, SGOT, SGPT) including TNF-α and IL-6, were estimated in blood. Results: Oxidative stress and inflammatory markers were significantly increased in the HFD treated group. BAC treatment protected rats from HFD mediated alterations. Discussion \& conclusion: Our results indicate that baicalein provides protection against hyperlipidemic stress and redox imbalance induced by HFD in rats.",

keywords = "Hyperlipidaemia, baicalein, oxidative stress, blood, liver, rat",

author = "S.S. Tripathi and R. Kumar and A. Bissoyi and S.I. Rizvi",

year = "2020",

month = may,

day = "12",

doi = "10.1080/13813455.2020.1760890",

language = "English",

volume = "128",

pages = "1156--1164",

journal = "Archives of Physiology and Biochemistry",

issn = "1381-3455",

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TY - JOUR

T1 - Baicalein maintains redox balance in experimental hyperlipidemic rats

AU - Tripathi, S.S.

AU - Kumar, R.

AU - Bissoyi, A.

AU - Rizvi, S.I.

PY - 2020/5/12

Y1 - 2020/5/12

N2 - Context: An altered lipid profile may lead to the development of CVD. Objective: We evaluated the protective role of baicalein (BAC) against lipidemic and oxidative stress in hyperlipidemic challenged Wistar rats. Materials and methods: Male Wistar rats were given a high-fat diet (HFD) (suspension (w/v) of 0.5% cholesterol, 3% coconut oil and 0.25% cholic acid for 30 days) to create a hyperlipidemic model. BAC was supplemented to experimental rats (80 mg/kg body weight). Biomarkers of oxidative stress including ROS, FRAP, GSH, PMRS, AGE, MDA, PCO, AOPP, and other parameters (Paraoxonase-1, SGOT, SGPT) including TNF-α and IL-6, were estimated in blood. Results: Oxidative stress and inflammatory markers were significantly increased in the HFD treated group. BAC treatment protected rats from HFD mediated alterations. Discussion & conclusion: Our results indicate that baicalein provides protection against hyperlipidemic stress and redox imbalance induced by HFD in rats.

AB - Context: An altered lipid profile may lead to the development of CVD. Objective: We evaluated the protective role of baicalein (BAC) against lipidemic and oxidative stress in hyperlipidemic challenged Wistar rats. Materials and methods: Male Wistar rats were given a high-fat diet (HFD) (suspension (w/v) of 0.5% cholesterol, 3% coconut oil and 0.25% cholic acid for 30 days) to create a hyperlipidemic model. BAC was supplemented to experimental rats (80 mg/kg body weight). Biomarkers of oxidative stress including ROS, FRAP, GSH, PMRS, AGE, MDA, PCO, AOPP, and other parameters (Paraoxonase-1, SGOT, SGPT) including TNF-α and IL-6, were estimated in blood. Results: Oxidative stress and inflammatory markers were significantly increased in the HFD treated group. BAC treatment protected rats from HFD mediated alterations. Discussion & conclusion: Our results indicate that baicalein provides protection against hyperlipidemic stress and redox imbalance induced by HFD in rats.

KW - Hyperlipidaemia

KW - baicalein

KW - oxidative stress

KW - blood

KW - liver

KW - rat

UR - https://www.scopus.com/pages/publications/85084826166

U2 - 10.1080/13813455.2020.1760890

DO - 10.1080/13813455.2020.1760890

M3 - Article

SN - 1381-3455

VL - 128

SP - 1156

EP - 1164

JO - Archives of Physiology and Biochemistry

JF - Archives of Physiology and Biochemistry

ER -

Baicalein maintains redox balance in experimental hyperlipidemic rats

Abstract

Keywords

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