Balancing Hormone Therapy: Mitigating Adverse Effects of Androgen-Deprivation Therapy and Exploring Alternatives in Prostate Cancer Management

Lisa M Gudenkauf, Struan Gray, Brian D Gonzalez, Ashwin Sachdeva, Karen Autio

Research output: Contribution to journalReview articlepeer-review

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Abstract

Androgen-deprivation therapy (ADT) is well established as the standard of care in metastatic prostate cancer (PCa) management; however, ADT has significant adverse effects (AEs) that must be addressed. This review aims to highlight opportunities to mitigate AEs of ADT and explore alternatives in PCa management. Specifically, we discuss behavioral and pharmacologic strategies for mitigating ADT AEs as well as ADT-sparing approaches for hormone-sensitive and castration-resistant PCa. Equipped with effective mitigation strategies and possible alternatives, clinicians and researchers can optimize health-related quality of life for patients currently receiving ADT for PCa and consider treatments that spare patients from AEs of ADT.

Original languageEnglish
Article numbere433126
JournalAmerican Society of Clinical Oncology educational book / ASCO. American Society of Clinical Oncology. Meeting
Volume44
Issue number3
Early online date24 May 2024
DOIs
Publication statusPublished - 24 Jun 2024
EventASCO Annual Meeting 2024 - Chicago, United States
Duration: 31 May 20244 Jun 2024

Keywords

  • Humans
  • Male
  • Androgen Antagonists/therapeutic use
  • Prostatic Neoplasms/drug therapy
  • Quality of Life
  • Antineoplastic Agents, Hormonal/therapeutic use
  • Disease Management

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