Behavior in Huntington's disease: dissociating cognition-based and mood-based changes.

Jennifer C. Thompson; Julie S. Snowden; David Craufurd; David Neary

doi:10.1176/appi.neuropsych.14.1.37

Behavior in Huntington's disease: dissociating cognition-based and mood-based changes.

Jennifer C. Thompson, Julie S. Snowden, David Craufurd, David Neary

Division of Evolution, Infection and Genomics

Research output: Contribution to journal › Article › peer-review

Abstract

The authors examined the relationship of three dimensions of behavioral change (Apathy, Depression, and Irritability) measured by the Problem Behaviors Assessment for Huntington's Disease (PBA-HD) to cognitive and motor indices of disease severity. The Apathy subscale was highly correlated with both cognitive and motor impairment; the Irritability and Depression subscales were not. The findings suggest that certain behavioral alterations are intrinsic to the evolution and progression of HD, whereas others are more variable and are independent of other indices of disease progression.

Original language	English
Pages (from-to)	37-43
Number of pages	6
Journal	Journal of Neuropsychiatry and Clinical Neurosciences
Volume	14
Issue number	1
DOIs	https://doi.org/10.1176/appi.neuropsych.14.1.37
Publication status	Published - 2002

Keywords

Activities of Daily Living
Adult
physiology: Affect
Aged
Aged, 80 and over
physiology: Cognition
Cross-Sectional Studies
Disease Progression
Female
Humans
diagnosis: Huntington Disease
physiology: Irritable Mood
Male
Middle Aged
Neurologic Examination
Neuropsychological Tests
physiology: Psychomotor Performance
Research Support, Non-U.S. Gov't
physiology: Speech

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10.1176/appi.neuropsych.14.1.37

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title = "Behavior in Huntington's disease: dissociating cognition-based and mood-based changes.",

abstract = "The authors examined the relationship of three dimensions of behavioral change (Apathy, Depression, and Irritability) measured by the Problem Behaviors Assessment for Huntington's Disease (PBA-HD) to cognitive and motor indices of disease severity. The Apathy subscale was highly correlated with both cognitive and motor impairment; the Irritability and Depression subscales were not. The findings suggest that certain behavioral alterations are intrinsic to the evolution and progression of HD, whereas others are more variable and are independent of other indices of disease progression.",

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KW - physiology: Cognition

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KW - physiology: Irritable Mood

KW - Male

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KW - physiology: Psychomotor Performance

KW - Research Support, Non-U.S. Gov't

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JF - Journal of Neuropsychiatry and Clinical Neurosciences

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Behavior in Huntington's disease: dissociating cognition-based and mood-based changes.

Abstract

Keywords

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