Beneficial hemodynamic and renal effects of adrenomedullin in an ovine model of heart failure

M. T. Rademaker; C. J. Charles; L. K. Lewis; T. G. Yandle; G. J S Cooper; D. H. Coy; A. M. Richards; M. G. Nicholls

Beneficial hemodynamic and renal effects of adrenomedullin in an ovine model of heart failure

M. T. Rademaker, C. J. Charles, L. K. Lewis, T. G. Yandle, G. J S Cooper, D. H. Coy, A. M. Richards, M. G. Nicholls

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Adrenomedullin is a recently discovered endogenous peptide with hypotensive and natriuretic actions in normal animals. Circulating and ventricular adrenomedullin are elevated in congestive heart failure, suggesting a possible role in the pathophysiology of this disease. No studies have previously examined the effects of adrenomedullin in heart failure. Methods and Results: Eight sheep with pacing-induced heart failure received human adrenomedullin(1-52) at 10 and 100 ng · kg-1 min-1 IV for 90 minutes each. Compared with vehicle control data, adrenomedullin increased plasma cAMP (high dose. P

Original language	English
Pages (from-to)	1983-1990
Number of pages	7
Journal	Circulation
Volume	96
Issue number	6
Publication status	Published - 16 Sept 1997

Keywords

Heart failure
Hemodynamics
Hormones
Pharmacokinetics
Vasodilation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@article{6097194ffaed481bbd941d473ee59da7,

title = "Beneficial hemodynamic and renal effects of adrenomedullin in an ovine model of heart failure",

abstract = "Background: Adrenomedullin is a recently discovered endogenous peptide with hypotensive and natriuretic actions in normal animals. Circulating and ventricular adrenomedullin are elevated in congestive heart failure, suggesting a possible role in the pathophysiology of this disease. No studies have previously examined the effects of adrenomedullin in heart failure. Methods and Results: Eight sheep with pacing-induced heart failure received human adrenomedullin(1-52) at 10 and 100 ng · kg-1 min-1 IV for 90 minutes each. Compared with vehicle control data, adrenomedullin increased plasma cAMP (high dose. P",

keywords = "Heart failure, Hemodynamics, Hormones, Pharmacokinetics, Vasodilation",

author = "Rademaker, {M. T.} and Charles, {C. J.} and Lewis, {L. K.} and Yandle, {T. G.} and Cooper, {G. J S} and Coy, {D. H.} and Richards, {A. M.} and Nicholls, {M. G.}",

year = "1997",

month = sep,

day = "16",

language = "English",

volume = "96",

pages = "1983--1990",

journal = "Circulation",

issn = "0009-7322",

publisher = "Lippincott Williams & Wilkins",

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TY - JOUR

T1 - Beneficial hemodynamic and renal effects of adrenomedullin in an ovine model of heart failure

AU - Rademaker, M. T.

AU - Charles, C. J.

AU - Lewis, L. K.

AU - Yandle, T. G.

AU - Cooper, G. J S

AU - Coy, D. H.

AU - Richards, A. M.

AU - Nicholls, M. G.

PY - 1997/9/16

Y1 - 1997/9/16

N2 - Background: Adrenomedullin is a recently discovered endogenous peptide with hypotensive and natriuretic actions in normal animals. Circulating and ventricular adrenomedullin are elevated in congestive heart failure, suggesting a possible role in the pathophysiology of this disease. No studies have previously examined the effects of adrenomedullin in heart failure. Methods and Results: Eight sheep with pacing-induced heart failure received human adrenomedullin(1-52) at 10 and 100 ng · kg-1 min-1 IV for 90 minutes each. Compared with vehicle control data, adrenomedullin increased plasma cAMP (high dose. P

AB - Background: Adrenomedullin is a recently discovered endogenous peptide with hypotensive and natriuretic actions in normal animals. Circulating and ventricular adrenomedullin are elevated in congestive heart failure, suggesting a possible role in the pathophysiology of this disease. No studies have previously examined the effects of adrenomedullin in heart failure. Methods and Results: Eight sheep with pacing-induced heart failure received human adrenomedullin(1-52) at 10 and 100 ng · kg-1 min-1 IV for 90 minutes each. Compared with vehicle control data, adrenomedullin increased plasma cAMP (high dose. P

KW - Heart failure

KW - Hemodynamics

KW - Hormones

KW - Pharmacokinetics

KW - Vasodilation

M3 - Article

C2 - 9323090

SN - 0009-7322

VL - 96

SP - 1983

EP - 1990

JO - Circulation

JF - Circulation

IS - 6

ER -

Beneficial hemodynamic and renal effects of adrenomedullin in an ovine model of heart failure

Abstract

Keywords

UN SDGs

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