Better than Nature: nicotinamide biomimetics that outperform natural coenzymes

Tanja Knaus, Caroline E Paul, Colin Levy, Simon De Vries, Francesco Mutti, F Hollmann, Nigel Scrutton

    Research output: Contribution to journalArticlepeer-review


    The search for affordable, green biocatalytic processes is a challenge for chemicals manufacture. Redox biotransformations are potentially attractive, but they rely on unstable and expensive nicotinamide coenzymes that have prevented their widespread exploitation. Stoichiometric use of natural coenzymes is not viable economically, and the instability of these molecules hinders catalytic processes that employ coenzyme recycling. Here, we investigate the efficiency of man-made synthetic biomimetics of the natural coenzymes NAD(P)H in redox biocatalysis. Extensive studies with a range of oxidoreductases belonging to the “ene” reductase family show that these biomimetics are excellent analogues of the natural coenzymes, revealed also in crystal structures of the ene reductase XenA with selected biomimetics. In selected cases, these biomimetics outperform the natural coenzymes. “Better-than-Nature” biomimetics should find widespread application in fine and specialty chemicals production by harnessing the power of high stereo-, regio-, and chemoselective redox biocatalysts and enabling reactions under mild conditions at low cost.
    Original languageEnglish
    Pages (from-to)1033-1039
    JournalAmerican Chemical Society. Journal
    Issue number3
    Publication statusPublished - 3 Jan 2016


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