@article{08f1764ea8a3413b9a0b90f06377ef00,
title = "Beyond episodic memory: Semantic processing as independent predictor of hippocampal/perirhinal volume in aging and mild cognitive impairment due to Alzheimer's disease",
abstract = "Objective: Given that lexical-semantic decline precedes episodic memory deficits in the Alzheimer's disease (AD) timeline, it is expected that performance on a lexical-semantic task would be associated with mediotemporal volumes independently of the association this region has with episodic memory in the early stage of AD. Method: Fifty patients with mild cognitive impairment due to AD and 50 healthy adults completed tests of lexical-semantic skills (category fluency test), episodic memory for semantically relevant material (prose memory test), episodic memory for non semantically relevant material (Rey-Osterrieth Figure test), lexical-executive abilities (letter fluency test), and a neurostructural MRI. Hippocampal, perirhinal, entorhinal, temporopolar, and orbitofrontal volumes were extracted. The association between test performance and volume of each region was tested using partial correlations (age-education corrected). The improvement (-R2) in predicting volumetric indices offered by episodicmemory/ lexical-semantic processing, once accounting for their counterpart, was tested using hierarchical regressions. Results: There were no significant findings for control indices. Prose memory accounted for independent portions of volumetric variability within almost all regions. Category fluency accounted for independent portions of volumetric variability of left and right hippocampus and left perirhinal cortex in addition to the predictive strength of the Rey-Osterrieth Figure, and for an independent portion of volumetric variability in the left hippocampus in addition to the predictive strength of prose memory. Conclusions: There was an association between hippocampal and perirhinal volume and lexical-semantic processing in addition to the contribution given by episodic memory. This statistical separation supports the importance of lexical-semantic processing as independent indicator of AD.",
keywords = "Category fluency, Mild cognitive impairment, Perirhinal cortex, Preclinical",
author = "A. Venneri and M. Mitolo and L. Beltrachini and S. Varma and {Della Pieta}, C. and C. Jahn-Carta and Frangi, {A. F.} and {De Marco}, Matteo",
note = "Funding Information: This study was partially supported by Grant 42/RF-2010-2321718 by the Italian Ministry of Health and partial funding from the European Union Seventh Framework Program (FP7/2007-2013) under Grant Agreement 601055, Virtual Physiological Human: DementiA Research Enabled by IT (VPH-DARE@IT) and Engineering and Physical Sciences Research Council (EPSRC), Grant EP/M006328/1, One-Srop-Shop Microstructure-Sensitive Perfusion/Diffusion MRI: Application to Vascular Cognitive Impairment (OCEAN), to Alejandro F. Frangi and Annalena Venneri. This is a summary of independent research carried out at the NIHR Sheffield Biomedical Research Centre (Translational Neuroscience). Funding Information: This study was partially supported by Grant 42/RF-2010-2321718 by the Italian Ministry of Health and partial funding from the European Union Seventh Framework Program (FP7/2007-2013) under Grant Agreement 601055, Virtual Physiological Human: DementiA Research Enabled by IT (VPH-DARE@IT) and Engineering and Physical Sciences Research Council (EPSRC), Grant EP/M006328/1, One-Srop-Shop Microstructure-Sensitive Perfusion/Diffusion MRI: Application to Vascular Cognitive Impairment (OCEAN), to Alejandro F. Frangi and Annalena Venneri. This is a summary of independent research carried out at the NIHR Sheffield Biomedical Research Centre (Translational Neuroscience). The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR, or the Department of Health. We thank Francesca Meneghello and her team in the Neuropsychology Unit, and the MRI technical Team, at IRCCS Fondazione Ospedale San Camillo, Venice, Italy. Publisher Copyright: {\textcopyright} 2019 American Psychological Association.",
year = "2019",
month = may,
doi = "10.1037/neu0000534",
language = "English",
volume = "33",
pages = "523--533",
journal = "Neuropsychology",
issn = "0894-4105",
publisher = "American Psychological Association",
number = "4",
}