Binary behaviour of an oxidation-responsive MRI nano contrast agent

Damien Jeanmaire; Grigore A. Timco; Arianna Gennari; Stephen Sproules; Kaye J. Williams; Richard E. P. Winpenny; Nicola Tirelli

doi:10.1039/C4cc08024f

Binary behaviour of an oxidation-responsive MRI nano contrast agent

Damien Jeanmaire, Grigore A. Timco, Arianna Gennari, Stephen Sproules, Kaye J. Williams, Richard E. P. Winpenny, Nicola Tirelli

Pharmacy

Research output: Contribution to journal › Article › peer-review

Abstract

A new nano contrast agent has been prepared incorporating a molecular magnet in oxidation-responsive nanoparticles; this system has shown a remarkable sensitivity to hydrogen peroxide (detection down to at least 40 mu M), which was used as a model reactive oxygen species. Surprisingly, the response had a binary (off/on) character, due to a non linear cascade relation between extent of oxidation and water permeability in the particles.

Original language	English
Pages (from-to)	1074-1076
Number of pages	3
Journal	Chemical Communications
Volume	51
Issue number	6
DOIs	https://doi.org/10.1039/C4cc08024f
Publication status	Published - 2015

Keywords

reactive oxygen
nanoparticles
inflammation
stress
gadolinium
complexes

Access to Document

10.1039/C4cc08024f

Cite this

@article{0d82f98a8014447082eafe627bb20e8d,

title = "Binary behaviour of an oxidation-responsive MRI nano contrast agent",

abstract = "A new nano contrast agent has been prepared incorporating a molecular magnet in oxidation-responsive nanoparticles; this system has shown a remarkable sensitivity to hydrogen peroxide (detection down to at least 40 mu M), which was used as a model reactive oxygen species. Surprisingly, the response had a binary (off/on) character, due to a non linear cascade relation between extent of oxidation and water permeability in the particles.",

keywords = "reactive oxygen, nanoparticles, inflammation, stress, gadolinium, complexes",

author = "Damien Jeanmaire and Timco, {Grigore A.} and Arianna Gennari and Stephen Sproules and Williams, {Kaye J.} and Winpenny, {Richard E. P.} and Nicola Tirelli",

note = "Aw9gl Times Cited:0 Cited References Count:24",

year = "2015",

doi = "10.1039/C4cc08024f",

language = "English",

volume = "51",

pages = "1074--1076",

journal = "Chemical Communications",

issn = "1364-548X",

publisher = "Royal Society of Chemistry",

number = "6",

}

TY - JOUR

T1 - Binary behaviour of an oxidation-responsive MRI nano contrast agent

AU - Jeanmaire, Damien

AU - Timco, Grigore A.

AU - Gennari, Arianna

AU - Sproules, Stephen

AU - Williams, Kaye J.

AU - Winpenny, Richard E. P.

AU - Tirelli, Nicola

N1 - Aw9gl Times Cited:0 Cited References Count:24

PY - 2015

Y1 - 2015

N2 - A new nano contrast agent has been prepared incorporating a molecular magnet in oxidation-responsive nanoparticles; this system has shown a remarkable sensitivity to hydrogen peroxide (detection down to at least 40 mu M), which was used as a model reactive oxygen species. Surprisingly, the response had a binary (off/on) character, due to a non linear cascade relation between extent of oxidation and water permeability in the particles.

AB - A new nano contrast agent has been prepared incorporating a molecular magnet in oxidation-responsive nanoparticles; this system has shown a remarkable sensitivity to hydrogen peroxide (detection down to at least 40 mu M), which was used as a model reactive oxygen species. Surprisingly, the response had a binary (off/on) character, due to a non linear cascade relation between extent of oxidation and water permeability in the particles.

KW - reactive oxygen

KW - nanoparticles

KW - inflammation

KW - stress

KW - gadolinium

KW - complexes

U2 - 10.1039/C4cc08024f

DO - 10.1039/C4cc08024f

M3 - Article

SN - 1364-548X

VL - 51

SP - 1074

EP - 1076

JO - Chemical Communications

JF - Chemical Communications

IS - 6

ER -

Binary behaviour of an oxidation-responsive MRI nano contrast agent

Abstract

Keywords

Access to Document

Fingerprint

Cite this