Binary behaviour of an oxidation-responsive MRI nano contrast agent

Damien Jeanmaire, Grigore A. Timco, Arianna Gennari, Stephen Sproules, Kaye J. Williams, Richard E. P. Winpenny, Nicola Tirelli

Research output: Contribution to journalArticlepeer-review


A new nano contrast agent has been prepared incorporating a molecular magnet in oxidation-responsive nanoparticles; this system has shown a remarkable sensitivity to hydrogen peroxide (detection down to at least 40 mu M), which was used as a model reactive oxygen species. Surprisingly, the response had a binary (off/on) character, due to a non linear cascade relation between extent of oxidation and water permeability in the particles.
Original languageEnglish
Pages (from-to)1074-1076
Number of pages3
JournalChemical Communications
Issue number6
Publication statusPublished - 2015


  • reactive oxygen
  • nanoparticles
  • inflammation
  • stress
  • gadolinium
  • complexes


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