Binding and interstitial penetration of liposomes within avascular tumor spheroids

Kostas Kostarelos; D Emfietzoglou; A Papakostas; W.H. Yang; A. Ballangrud; G Sgouros

Binding and interstitial penetration of liposomes within avascular tumor spheroids

Kostas Kostarelos, D Emfietzoglou, A Papakostas, W.H. Yang, A. Ballangrud, G Sgouros

Pharmacy

Research output: Contribution to journal › Article › peer-review

Abstract

The liposomal delivery of cancer therapeutics, including gene therapy vectors, is an area of intense study. Poor penetration of liposomes into interstitial tumor spaces remains a problem, however. In this work, the penetration of different liposomal formulations into prostate carcinoma spheroids was examined. Spheroid penetration was assessed by confocal microscopy of fluorescently labeled liposomes.

Original language	English
Pages (from-to)	713-21
Journal	International Journal of Cancer
Volume	112
Issue number	4
Publication status	Published - 2004

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Binding and interstitial penetration of liposomes within avascular tumor spheroids",

abstract = "The liposomal delivery of cancer therapeutics, including gene therapy vectors, is an area of intense study. Poor penetration of liposomes into interstitial tumor spaces remains a problem, however. In this work, the penetration of different liposomal formulations into prostate carcinoma spheroids was examined. Spheroid penetration was assessed by confocal microscopy of fluorescently labeled liposomes.",

author = "Kostas Kostarelos and D Emfietzoglou and A Papakostas and W.H. Yang and A. Ballangrud and G Sgouros",

year = "2004",

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T1 - Binding and interstitial penetration of liposomes within avascular tumor spheroids

AU - Kostarelos, Kostas

AU - Emfietzoglou, D

AU - Papakostas, A

AU - Yang, W.H.

AU - Ballangrud, A.

AU - Sgouros, G

PY - 2004

Y1 - 2004

N2 - The liposomal delivery of cancer therapeutics, including gene therapy vectors, is an area of intense study. Poor penetration of liposomes into interstitial tumor spaces remains a problem, however. In this work, the penetration of different liposomal formulations into prostate carcinoma spheroids was examined. Spheroid penetration was assessed by confocal microscopy of fluorescently labeled liposomes.

AB - The liposomal delivery of cancer therapeutics, including gene therapy vectors, is an area of intense study. Poor penetration of liposomes into interstitial tumor spaces remains a problem, however. In this work, the penetration of different liposomal formulations into prostate carcinoma spheroids was examined. Spheroid penetration was assessed by confocal microscopy of fluorescently labeled liposomes.

M3 - Article

SN - 0020-7136

VL - 112

SP - 713

EP - 721

JO - International Journal of Cancer

JF - International Journal of Cancer

IS - 4

ER -

Binding and interstitial penetration of liposomes within avascular tumor spheroids

Abstract

UN SDGs

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